Reactome | AES [nucleoplasm]

AES [nucleoplasm]

Stable Identifier

R-HSA-4648963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GRG

Locations in the PathwayBrowser for interactor UniProt:P52597 HNRNPF

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External Reference Information

External Reference

UniProt:Q08117 TLE5

Gene Names

TLE5, AES, GRG, GRG5

Chain

chain:1-197

Reference Genes

COSMIC (genes):AES TLE5

dbSNP Gene:166 TLE5

ENSEMBL:ENSG00000104964 AES

Participates

as a component of

TLE:AES [nucleoplasm] (Homo sapiens)

as an input of

TLE forms non-functional complexes with AES (Homo sapiens)

Interactors (130)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3E5 PTRH2	2	PTRH2 [mitochondrial outer membrane] (R-HSA-5696909) PolyUb-PTRH2 [mitochondrial outer membrane] (R-HSA-6783190)	0.69	7
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.675	4
UniProt:Q9UH92 MLX	1	MLX [nucleoplasm] (R-HSA-163695)	0.666	4
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.666	4
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.666	4
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.666	4
UniProt:A1L4K1 FSD2			0.666	4
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.666	5
UniProt:Q9BRQ3 NUD22			0.666	4
UniProt:Q8N5A5 ZGPAT			0.666	4
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.666	4
UniProt:Q9BSW2 CRACR2A	2	CRACR2A [extracellular region] (R-HSA-6806289) CRACR2A [specific granule lumen] (R-HSA-6799553)	0.666	4
UniProt:P35711 SOX5			0.659	4
UniProt:Q05925 HME1			0.569	3
UniProt:Q04726 TLE3	2	Ub-TLE3 [nucleoplasm] (R-HSA-3322374) TLE3 [nucleoplasm] (R-HSA-3322363)	0.564	2
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.564	3
UniProt:Q9H5Z6 F124B			0.556	3
UniProt:Q8N5A5-2 ZGPAT			0.556	3
UniProt:Q9UFD9 RIM3A			0.556	3
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q8IYR0 CF206			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q96FQ7 CR018			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P61968 LMO4			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9Y333 LSM2	2	LSM2 [nucleoplasm] (R-HSA-71894) LSM2 [cytosol] (R-HSA-429849)	0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q96A72 MAGOHB	1	MAGOHB [nucleoplasm] (R-HSA-8867888)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q5TAL4 Q5TAL4			0.556	3
UniProt:O43186 CRX			0.556	3
UniProt:Q9BQY4 RHXF2			0.556	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q9H614 Q9H614			0.556	3
UniProt:Q86VM6 Q86VM6			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q86V42 F124A			0.556	3
UniProt:Q9UBB6 NCDN			0.556	3
UniProt:Q9H609 ZN576			0.556	3
UniProt:Q9HBI0 PARVG			0.556	3
UniProt:Q15014 MORF4L2	1	MORF4L2 [nucleoplasm] (R-HSA-3322945)	0.556	3
UniProt:O15409 FOXP2			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q8IV13 CCNJL			0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q14689-6 DIP2A			0.556	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:O15119 TBX3	2	TBX3 [nucleoplasm] (R-HSA-9825678) p-S742 TBX3 [nucleoplasm] (R-HSA-9825680)	0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:P47897-2 QARS1			0.556	3
UniProt:Q15475 SIX1	1	SIX1 [nucleoplasm] (R-HSA-9757860)	0.556	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.556	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.556	3
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q9HC98 NEK6	2	p-S206-NEK6 [cytosol] (R-HSA-2984253) NEK6 [cytosol] (R-HSA-2530596)	0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:Q12899 TRIM26	1	TRIM26 [cytosol] (R-HSA-5624324)	0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.556	3
UniProt:Q8WTP8 AEN			0.556	3
UniProt:Q96PN8 TSSK3			0.556	3
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q96Q77 CIB3			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:Q8IV54 Q8IV54			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q9UJX0 OSGI1			0.556	3
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.556	3
UniProt:Cerebral CLONE			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q96EP0-3 RNF31			0.556	3
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.556	3
UniProt:Q8N684 CPSF7	2	CPSF7 [cytosol] (R-HSA-9715140) CPSF7 [nucleoplasm] (R-HSA-72012)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	5
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.556	3
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.556	3
UniProt:O75909 CCNK	1	CCNK [nucleoplasm] (R-HSA-6796619)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O43167 ZBT24			0.556	3
UniProt:Q8TES7-6 FBF1			0.556	3
UniProt:Q7RTU3 OLIG3			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:P0DTD1-PRO_0000449630 REP			0.527	2
UniProt:Q04725 TLE2	2	Ub-TLE2 [nucleoplasm] (R-HSA-3322370) TLE2 [nucleoplasm] (R-HSA-212354)	0.527	3
UniProt:Q0D2K3 RIPP1			0.527	3
UniProt:Q14774 HLX			0.527	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.527	2
UniProt:Q9NQZ5 STARD7	3	pre-STARD7 [mitochondrial intermembrane space] (R-HSA-9839780) cytosolic STARD7 [mitochondrial outer membrane] (R-HSA-9856506) mito-STARD7 [mitochondrial outer membrane] (R-HSA-8873841)	0.527	2
UniProt:Q5TAB7 RIPPLY2	1	RIPPLY2 [nucleoplasm] (R-HSA-9825566)	0.527	3
UniProt:O75360 PROP1			0.508	4