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AURKB [nucleoplasm]
Stable Identifier
R-HSA-4655360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Aurora B
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
Regulation of MECP2 expression and activity (Homo sapiens)
AURKB phosphorylates MECP2 at S423 (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AURKB binds TP53 (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
AURKB phosphorylates TP53 (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20,S269,T284-TP53 [nucleoplasm] (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
Chromosome passenger complex [nucleoplasm] (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GD4 AURKB
Gene Names
AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Chain
chain:1-344
Reference Genes
BioGPS Gene:9212 AURKB
COSMIC (genes):AURKB AURKB
CTD Gene:9212 AURKB
dbSNP Gene:9212 AURKB
ENSEMBL:ENSG00000178999 AURKB
ENSEMBL:ENSG00000178999.13 AURKB
HGNC:11390 AURKB
KEGG Gene (Homo sapiens):9212 AURKB
Monarch:9212 AURKB
NCBI Gene:9212 AURKB
OMIM:604970 AURKB
UCSC:Q96GD4 AURKB
Reference Transcript
RefSeq:NM_001313952.1 AURKB
RefSeq:NM_001313955.1 AURKB
RefSeq:NM_001284526.1 AURKB
RefSeq:XM_011524070.2 AURKB
RefSeq:NM_001313951.1 AURKB
RefSeq:NM_001313954.1 AURKB
RefSeq:NM_004217.3 AURKB
RefSeq:NM_001313953.1 AURKB
RefSeq:XM_017025307.1 AURKB
RefSeq:NM_001256834.2 AURKB
RefSeq:XM_011524072.2 AURKB
RefSeq:NM_001313950.1 AURKB
Other Identifiers
11720203_a_at
16840902
209464_PM_at
209464_at
33266_at
3744271
3744272
3744273
3744274
3744275
3744276
3744278
3744279
3744281
3744282
3744283
3744284
3744290
3744291
3744292
3744293
3744294
8012403
9212
A_23_P130182
GE62547
GE84968
GO:0000122
GO:0000166
GO:0000278
GO:0000281
GO:0000775
GO:0000776
GO:0000779
GO:0000910
GO:0001934
GO:0002376
GO:0002903
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007049
GO:0007051
GO:0007052
GO:0007059
GO:0008608
GO:0009838
GO:0010369
GO:0012501
GO:0015630
GO:0016301
GO:0016310
GO:0016570
GO:0016740
GO:0019900
GO:0023052
GO:0030496
GO:0031616
GO:0032091
GO:0032133
GO:0032200
GO:0032212
GO:0032465
GO:0032466
GO:0032467
GO:0034501
GO:0034644
GO:0036089
GO:0036211
GO:0043226
GO:0043687
GO:0044022
GO:0044839
GO:0044878
GO:0045824
GO:0046777
GO:0048856
GO:0051233
GO:0051256
GO:0051301
GO:0051973
GO:0051983
GO:0061024
GO:0062033
GO:0090267
GO:0097431
GO:0098542
GO:0098772
GO:0106310
GO:0140014
GO:0140096
GO:0140678
GO:1901796
GO:1901970
GO:1902425
GO:1903490
GO:1904355
GO:1905116
GO:1990023
HMNXSV003048163
Hs.221197.0.A1_3p_at
Hs.221197.0.A1_3p_x_at
ILMN_1684217
PH_hs_0025861
TC17001109.hg
g5688865_3p_at
Participates
as a component of
Chromosome passenger complex [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20,S269,T284-TP53 [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
as an input of
AURKB binds TP53 (Homo sapiens)
Other forms of this molecule
polySUMO2,3-K202-AURKB [cytosol]
AURKB [cytosol]
Inferred To
Homologues of AURKB [nucleoplasm]
(Drosophila melanogaster)
AURKB [nucleoplasm]
(Bos taurus)
AURKB [nucleoplasm]
(Canis familiaris)
AURKB [nucleoplasm]
(Danio rerio)
AURKB [nucleoplasm]
(Drosophila melanogaster)
AURKB [nucleoplasm]
(Mus musculus)
AURKB [nucleoplasm]
(Rattus norvegicus)
AURKB [nucleoplasm]
(Sus scrofa)
AURKB [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of AURKB [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_001300881.1
,
NP_001300879.1
,
XP_011522372.1
,
NP_001300880.1
,
NP_001300884.1
,
NP_004208.2
,
XP_016880796.1
,
NP_001300882.1
,
NP_001271455.1
,
NP_001243763.1
,
NP_001300883.1
,
XP_011522374.1
ZINC - World Drugs
AURKB_HUMAN
Guide to Pharmacology - Targets
1937
OpenTargets
ENSG00000178999
ZINC - FDA approved
AURKB_HUMAN
ZINC - Substances
AURKB_HUMAN
ZINC target
Q96GD4
ZINC - Biogenic
AURKB_HUMAN
PRO
Q96GD4
PDB
4AF3
ZINC - Investigational
AURKB_HUMAN
ZINC - Metabolites
AURKB_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000178999-AURKB
GeneCards
Q96GD4
Ensembl
ENSG00000178999
,
ENST00000534871
,
ENSP00000313950
,
ENST00000585124
,
ENSP00000463999
,
ENSP00000462207
,
ENST00000578549
,
ENSP00000443869
,
ENST00000316199
Pharos - Targets
Q96GD4
ZINC - Predictions - Purchasable
AURKB_HUMAN
HMDB Protein
HMDBP01421
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.953
19
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.952
13
UniProt:Q53HL2 CDCA8
3
polySUMO2,3-CDCA8 [cytosol]
(R-HSA-4655328)
CDCA8 [nucleoplasm]
(R-HSA-4655357)
CDCA8 [cytosol]
(R-HSA-375288)
0.827
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.784
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.727
5
UniProt:Q8WYJ6 SEPT1
0.704
6
UniProt:Q99986 VRK1
2
VRK1 [nucleoplasm]
(R-HSA-2528998)
VRK1 [cytosol]
(R-HSA-2995381)
0.65
14
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.633
5
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.626
5
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.602
4
UniProt:Q86XJ1 GA2L3
0.584
4
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.569
3
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.564
3
UniProt:Q9NQS7-1 INCENP
0.558
2
UniProt:O15392-2 BIRC5
0.544
2
UniProt:O15392-1 BIRC5
0.544
2
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.544
8
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
UniProt:Q9UN86 G3BP2
1
G3BP2 [cytosol]
(R-HSA-9729507)
0.527
2
UniProt:Q16659 MAPK6
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
2
UniProt:Q9P2J3 KLHL9
1
KLHL9 [cytosol]
(R-HSA-976056)
0.525
2
UniProt:Q9P2N7 KLHL13
1
KLHL13 [cytosol]
(R-HSA-976041)
0.525
2
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.483
2
UniProt:Q8TDD1 DDX54
0.483
2
UniProt:O75410 TACC1
0.463
2
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.463
5
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