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AURKB [nucleoplasm]
Stable Identifier
R-HSA-4655360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Aurora B
Locations in the PathwayBrowser for interactor UniProt:Q8WYJ6 SEPT1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
Regulation of MECP2 expression and activity (Homo sapiens)
AURKB phosphorylates MECP2 at S423 (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AURKB binds TP53 (Homo sapiens)
AURKB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GD4 AURKB
Gene Names
AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
Chain
chain:1-344
Reference Genes
BioGPS Gene:9212 AURKB
COSMIC (genes):AURKB AURKB
CTD Gene:9212 AURKB
dbSNP Gene:9212 AURKB
ENSEMBL:ENSG00000178999 AURKB
HGNC:11390 AURKB
KEGG:hsa:9212 AURKB
Monarch:9212 AURKB
NCBI Gene:9212 AURKB
OMIM:604970 AURKB
UCSC:Q96GD4 AURKB
Reference Transcript
RefSeq:XM_047437050.1 AURKB
RefSeq:NM_001313954.1 AURKB
RefSeq:NM_001313955.1 AURKB
RefSeq:NM_001313950.2 AURKB
RefSeq:NM_001313952.1 AURKB
RefSeq:NM_001256834.3 AURKB
RefSeq:NM_004217.4 AURKB
RefSeq:XM_011524072.4 AURKB
RefSeq:XM_011524070.2 AURKB
RefSeq:NM_001284526.2 AURKB
RefSeq:NM_001313953.3 AURKB
RefSeq:NM_001313951.1 AURKB
RefSeq:XM_017025307.1 AURKB
Other Identifiers
11720203_a_at
16840902
209464_PM_at
209464_at
239219_3p_at
239219_PM_at
239219_at
33266_at
3744271
3744272
3744273
3744274
3744275
3744276
3744277
3744278
3744279
3744280
3744281
3744282
3744283
3744284
3744285
3744286
3744287
3744288
3744289
3744290
3744291
3744292
3744293
3744294
44224_at
8012403
9212
A_23_P130182
GE62547
GE84968
GO:0000122
GO:0000166
GO:0000278
GO:0000281
GO:0000775
GO:0000776
GO:0000779
GO:0000910
GO:0000922
GO:0002376
GO:0002903
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006355
GO:0006468
GO:0007010
GO:0007051
GO:0007052
GO:0010369
GO:0015630
GO:0016301
GO:0016740
GO:0019900
GO:0030496
GO:0031117
GO:0032133
GO:0032206
GO:0032465
GO:0032466
GO:0032467
GO:0032886
GO:0034501
GO:0034644
GO:0036089
GO:0043226
GO:0043687
GO:0044839
GO:0044878
GO:0045824
GO:0051233
GO:0051256
GO:0051301
GO:0051315
GO:0051983
GO:0061024
GO:0061952
GO:0062033
GO:0090068
GO:0090267
GO:0090307
GO:0097431
GO:0106310
GO:0140096
GO:0140273
GO:0140896
GO:0160049
GO:1901796
GO:1901970
GO:1902425
GO:1903490
GO:1905116
GO:1990023
GO:1990758
HMNXSV003048163
Hs.221197.0.A1_3p_at
Hs.221197.0.A1_3p_x_at
ILMN_1684217
PH_hs_0025861
TC17001109.hg
g5688865_3p_at
Participates
as a component of
Chromosome passenger complex [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20,S269,T284-TP53 [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
as an input of
AURKB binds TP53 (Homo sapiens)
Other forms of this molecule
AURKB [cytosol]
polySUMO2,3-K202-AURKB [cytosol]
Inferred To
Homologues of AURKB [nucleoplasm]
(Drosophila melanogaster)
aurB [nucleoplasm]
(Drosophila melanogaster)
aurkb [nucleoplasm]
(Danio rerio)
aurkb [nucleoplasm]
(Xenopus tropicalis)
AURKB [nucleoplasm]
(Bos taurus)
AURKB [nucleoplasm]
(Canis familiaris)
AURKB [nucleoplasm]
(Sus scrofa)
Aurkb [nucleoplasm]
(Mus musculus)
Aurkb [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of AURKB [nucleoplasm]
(Gallus gallus)
aurA [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001300879.1
,
NP_001271455.1
,
XP_016880796.1
,
XP_011522374.1
,
NP_004208.2
,
XP_011522372.1
,
NP_001243763.1
,
XP_047293006.1
,
NP_001300880.1
,
NP_001300881.1
,
NP_001300882.1
,
NP_001300883.1
,
NP_001300884.1
ZINC - World Drugs
AURKB_HUMAN
Guide to Pharmacology - Targets
1937
OpenTargets
ENSG00000178999
ENSEMBL
ENSP00000313950
,
ENSG00000178999
,
ENST00000585124
,
ENST00000534871
,
ENSP00000443869
,
ENSP00000463999
,
ENSP00000462207
,
ENST00000316199
,
ENST00000578549
ZINC - FDA approved
AURKB_HUMAN
ZINC - Substances
AURKB_HUMAN
ZINC - Biogenic
AURKB_HUMAN
ZINC target
Q96GD4
PRO
Q96GD4
GlyGen
Q96GD4
PDB
4AF3
ZINC - Investigational
AURKB_HUMAN
ZINC - Metabolites
AURKB_HUMAN
GeneCards
AURKB
HPA
ENSG00000178999-AURKB
Pharos - Targets
Q96GD4
ZINC - Predictions - Purchasable
AURKB_HUMAN
HMDB Protein
HMDBP01421
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.964
23
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.952
13
UniProt:Q53HL2 CDCA8
3
polySUMO2,3-CDCA8 [cytosol]
(R-HSA-4655328)
CDCA8 [nucleoplasm]
(R-HSA-4655357)
CDCA8 [cytosol]
(R-HSA-375288)
0.868
10
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.834
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.784
5
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.712
6
UniProt:Q8WYJ6 SEPT1
0.704
6
UniProt:Q99986 VRK1
2
VRK1 [cytosol]
(R-HSA-2995381)
VRK1 [nucleoplasm]
(R-HSA-2528998)
0.65
14
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.633
5
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.602
4
UniProt:Q86XJ1 GA2L3
0.584
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.571
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.569
3
UniProt:Q58FG0 HS905
0.564
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.564
3
UniProt:Q9NQS7-1 INCENP
0.558
2
UniProt:O15392-1 BIRC5
0.544
2
UniProt:O15392-2 BIRC5
0.544
2
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.544
8
UniProt:Q16659 MAPK6
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.527
2
UniProt:Q9UN86 G3BP2
1
G3BP2 [cytosol]
(R-HSA-9729507)
0.527
2
UniProt:Q9UJX3 ANAPC7
2
ANAPC7 [cytosol]
(R-HSA-174242)
ANAPC7 [nucleoplasm]
(R-HSA-174204)
0.527
2
UniProt:O60232 ZNRD2
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:A6NHR9 SMHD1
0.527
2
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.527
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
2
UniProt:Q9P2J3 KLHL9
1
KLHL9 [cytosol]
(R-HSA-976056)
0.525
2
UniProt:Q9P2N7 KLHL13
1
KLHL13 [cytosol]
(R-HSA-976041)
0.525
2
UniProt:Q9HBJ7 UBP29
0.499
3
UniProt:Q8TDD1 DDX54
0.483
2
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.483
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.471
2
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.463
5
UniProt:O75410 TACC1
0.463
2
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