SUMOylation of NFKBIA with SUMO1

Stable Identifier
R-HSA-4656914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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NFKBIA (IKBA, IkappaBalpha) is SUMOylated at lysine-21 with SUMO1 (Desterro et al. 1998, Rodriguez et al. 2001, Liu et al. 2009). SUMOylation blocks ubiquitin-mediated proteolysis of NFKBIA and thereby inhibits NF-kappaB dependent transcription and acts as an anti-inflammatory. Adenosine signaling increases SUMOylation of NFKBIA with SUMO1. Nuclear import of NFKBIA is required for SUMOylation.
Literature References
PubMed ID Title Journal Year
19297320 Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation

Liu, Q, Colgan, SP, Khoury, J, Ibla, JC, Li, J

J. Biol. Chem. 2009
11124955 SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

Rodriguez, MS, Dargemont, C, Hay, RT

J. Biol. Chem. 2001
9734360 SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

Desterro, JM, Rodriguez, MS, Hay, RT

Mol. Cell 1998
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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