NFKBIA (IKBA, IkappaBalpha) is SUMOylated at lysine-21 with SUMO1 (Desterro et al. 1998, Rodriguez et al. 2001, Liu et al. 2009). SUMOylation blocks ubiquitin-mediated proteolysis of NFKBIA and thereby inhibits NF-kappaB dependent transcription and acts as an anti-inflammatory. Adenosine signaling increases SUMOylation of NFKBIA with SUMO1. Nuclear import of NFKBIA is required for SUMOylation.
Liu, Q, Colgan, SP, Khoury, J, Ibla, JC, Li, J
Rodriguez, MS, Dargemont, C, Hay, RT
Desterro, JM, Rodriguez, MS, Hay, RT
SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]
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