Reactome | SUMOylation of NFKBIA with SUMO1

SUMOylation of NFKBIA with SUMO1

Stable Identifier

R-HSA-4656914

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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NFKBIA (IKBA, IkappaBalpha) is SUMOylated at lysine-21 with SUMO1 (Desterro et al. 1998, Rodriguez et al. 2001, Liu et al. 2009). SUMOylation blocks ubiquitin-mediated proteolysis of NFKBIA and thereby inhibits NF-kappaB dependent transcription and acts as an anti-inflammatory. Adenosine signaling increases SUMOylation of NFKBIA with SUMO1. Nuclear import of NFKBIA is required for SUMOylation.

Literature References

PubMed ID	Title	Journal	Year
19297320	Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation Liu, Q, Colgan, SP, Khoury, J, Ibla, JC, Li, J	J. Biol. Chem.	2009
11124955	SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting Rodriguez, MS, Dargemont, C, Hay, RT	J. Biol. Chem.	2001
9734360	SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation Desterro, JM, Rodriguez, MS, Hay, RT	Mol. Cell	1998