SRD5A1 dehydrogenates TEST to DHTEST

Stable Identifier
R-HSA-469659
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Testosterone is converted to 5-alpha-dihydroxytestosterone
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The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 1 (SRD5A1) (Andersson & Russell 1990). SRD5A1 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References
PubMed ID Title Journal Year
2339109 Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

Andersson, S, Russell, DW

Proc Natl Acad Sci U S A 1990
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
Participants
Participates
Catalyst Activity

3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A1 [endoplasmic reticulum membrane]

This event is regulated
Positively by
Regulator
Summation

Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

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