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PIAS1,2-2 SUMOylate PPARG with SUMO1
Stable Identifier
R-HSA-4717461
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)
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As inferred from mouse homologs, PIAS1,2-2 SUMOylate PPARG with SUMO1 at lysine-107 and lysine-395 (lysine-77 and lysine-365 of the shorter variant 1). SUMOylation decreases the transcriptional activation activity of PPARG. SUMOylation at lysine-395 is ligand-dependent and causes PPARG to recruit corepressors such as NCOR and HDAC3.
Participants
Input
PPARG [nucleoplasm]
(Homo sapiens)
x 2
SUMO1:C93-UBE2I [nucleoplasm]
(Homo sapiens)
Output
monoSUMO1-K107,K395-PPARG [nucleoplasm]
(Homo sapiens)
x 2
UBE2I [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SUMOylation of intracellular receptors (Homo sapiens)
Catalyst Activity
SUMO transferase activity of PIAS1,2-2 [nucleoplasm]
Physical Entity
PIAS1,2-2 [nucleoplasm]
(Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Pias1,2-2 Sumoylate Pparg with Sumo1 (Mus musculus)
Authored
May, B (2013-10-11)
Reviewed
Niskanen, E (2018-05-09)
Niskanen, E (2018-08-08)
Created
May, B (2013-10-18)
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