PIAS1 SUMOylates THRB with SUMO1.

Stable Identifier
R-HSA-4719424
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS1 SUMOylates THRB with SUMO1 at lysine-50, lysine-146, and lysine-443 (Liu et al. 2012). SUMOylation is required for induction of gene expression in response to ligand (triiodothyroxine). In the absence of SUMOylation the repressor NCOR is not dismissed in response to ligand binding.
Literature References
PubMed ID Title Journal Year
22930759 Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation

Schultz, JJ, Liu, YY, Kogai, T, Mody, K, Brent, GA

J. Biol. Chem. 2012
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!