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monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
Stable Identifier
R-HSA-4719442
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Thyroid hormone receptor alpha, THA_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)
monoSUMO1-K283,K389-THRA-2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10827-2 THRA
Gene Names
THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2
Other Identifiers
11717773_a_at
11734119_a_at
11734120_x_at
11747680_a_at
11747681_x_at
11750897_a_at
11759126_a_at
11761993_a_at
1316_PM_at
1316_at
16833965
204100_PM_at
204100_at
214883_PM_at
214883_at
35846_PM_at
35846_at
3720696
3720697
3720698
3720702
3720703
3720705
3720706
3720707
3720709
3720710
3720713
3720714
3720715
3720716
3720717
3720718
3720719
3720720
3720721
3720722
3720723
3720724
3720725
3720727
3720729
4898680_3p_at
616_s_at
7067
8007008
86815_at
A_14_P108110
A_14_P130248
A_14_P200471
A_23_P207742
A_24_P262407
GE81253
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001502
GO:0001503
GO:0002154
GO:0002155
GO:0002157
GO:0002376
GO:0003013
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006629
GO:0007611
GO:0008016
GO:0008050
GO:0008270
GO:0009409
GO:0009755
GO:0009887
GO:0012501
GO:0016071
GO:0017025
GO:0017055
GO:0019904
GO:0022414
GO:0023052
GO:0030154
GO:0030218
GO:0030522
GO:0030878
GO:0031490
GO:0033032
GO:0042789
GO:0043226
GO:0043565
GO:0044877
GO:0045892
GO:0045925
GO:0045944
GO:0046872
GO:0048384
GO:0048856
GO:0050877
GO:0050994
GO:0060089
GO:0060509
GO:0065003
GO:0070324
GO:0090575
GO:0120162
GO:0140110
GO:0140296
GO:2000143
HMNXSV003009754
HMNXSV003017851
ILMN_1654613
ILMN_1661683
ILMN_1718182
M24748_cds2_s_at
M24899_at
PH_hs_0030854
TC17000488.hg
TC17002195.hg
TC17002196.hg
X55005_rna1_at
X55005mRNA_3p_s_at
g4507494_3p_s_at
p27287
Participates
as an output of
PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)
Other forms of this molecule
polySUMO3-K283,K389-THRA-2 [nucleoplasm]
THRA-2 [nucleoplasm]
Inferred To
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(Gallus gallus)
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(Mus musculus)
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(Sus scrofa)
nhr-2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K283,K389-THRA-2 [nucleoplasm]
(Caenorhabditis elegans)
nhr-7 [nucleoplasm]
(Caenorhabditis elegans)
nhr-85 [nucleoplasm]
(Caenorhabditis elegans)
thraa [nucleoplasm]
(Danio rerio)
sex-1 [nucleoplasm]
(Caenorhabditis elegans)
thra [nucleoplasm]
(Xenopus tropicalis)
THRA [nucleoplasm]
(Bos taurus)
unc-55 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 283
Coordinate
283
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 389
Coordinate
389
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001177847.1
,
NP_001177848.1
,
NP_955366.1
,
NP_003241.2
ZINC - World Drugs
THA_HUMAN
Guide to Pharmacology - Targets
588
OpenTargets
ENSG00000126351
ZINC - FDA approved
THA_HUMAN
ZINC - Substances
THA_HUMAN
ZINC target
P10827
ZINC - Biogenic
THA_HUMAN
PRO
P10827
PDB
4LNW
,
2H79
,
2H77
,
4LNX
,
1NAV
,
3ILZ
,
3HZF
,
7QDT
,
3JZB
ZINC - Investigational
THA_HUMAN
ZINC - Metabolites
THA_HUMAN
HPA
ENSG00000126351-THRA
GeneCards
P10827
Ensembl
ENSP00000395641
,
ENST00000264637
,
ENSP00000443972
,
ENST00000584985
,
ENSG00000126351
,
ENSP00000463466
,
ENST00000546243
,
ENST00000394121
,
ENSP00000264637
,
ENSP00000377679
,
ENST00000450525
Pharos - Targets
P10827
Orphanet
20806
ZINC - Predictions - Purchasable
THA_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.591
4
UniProt:O95971 CD160
1
CD160 [plasma membrane]
(R-HSA-198014)
0.556
3
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