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KDM6A [nucleoplasm]
Stable Identifier
R-HSA-4754224
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 6A ecNumber1.14.11.-/ecNumber, KDM6A_HUMAN, UTX
Locations in the PathwayBrowser for interactor UniProt:Q9C005 DPY30
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)
KDM6A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15550 KDM6A
Gene Names
KDM6A, UTX
Chain
chain:1-1401
Reference Genes
BioGPS Gene:7403 KDM6A
COSMIC (genes):KDM6A KDM6A
CTD Gene:7403 KDM6A
dbSNP Gene:7403 KDM6A
ENSEMBL:ENSG00000147050 KDM6A
HGNC:12637 KDM6A
KEGG:hsa:7403 KDM6A
Monarch:7403 KDM6A
NCBI Gene:7403 KDM6A
OMIM:300128 KDM6A
UCSC:O15550 KDM6A
Reference Transcript
RefSeq:NM_021140.3 KDM6A
Other Identifiers
11743085_a_at
11749091_a_at
17102861
203990_PM_s_at
203990_s_at
203991_PM_s_at
203991_s_at
203992_PM_s_at
203992_s_at
238220_PM_at
238220_at
39703_at
3975469
3975470
3975471
3975472
3975473
3975474
3975475
3975487
3975490
3975491
3975496
3975497
3975498
3975499
3975503
3975504
3975505
3975506
3975508
3975509
3975510
3975511
3975512
3975513
3975514
3975515
3975516
3975517
3975518
3975519
3975520
3975521
3975522
3975523
3975524
3975525
3975526
3975527
3975528
3975529
3975530
3975533
3975534
3975538
3975539
3975541
3975543
3975544
3975545
3975546
3975547
3975548
3975549
3975550
3975551
3975560
4035037
4035043
4035058
4035072
4035091
7403
8166956
86600_at
A_14_P116222
A_14_P139746
A_23_P217304
A_33_P3218955
A_33_P3340718
GE54033
GO:0000978
GO:0001666
GO:0001701
GO:0001843
GO:0003007
GO:0003016
GO:0003677
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006338
GO:0006355
GO:0007507
GO:0010468
GO:0010628
GO:0016491
GO:0021915
GO:0030154
GO:0031490
GO:0032452
GO:0032525
GO:0035097
GO:0035264
GO:0036211
GO:0042802
GO:0043226
GO:0044666
GO:0045793
GO:0045944
GO:0046872
GO:0048333
GO:0048568
GO:0048570
GO:0048856
GO:0051213
GO:0071305
GO:0071456
GO:0071558
GO:0071560
GO:0072359
GO:0140096
GO:1903298
GO:1904385
GO:1990859
HMNXSV003015225
Hs.13980.0.S1_3p_a_at
Hs.13980.0.S1_3p_s_at
Hs.201790.0.A1_3p_at
ILMN_1654488
PH_hs_0022992
TC0X000212.hg
g10863942_3p_a_at
g2580569_3p_a_at
Participates
as an input of
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)
PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)
as a component of
KDM6A:Fe2+ [nucleoplasm] (Homo sapiens)
MLL3-ASCOM [nucleoplasm] (Homo sapiens)
MLL4-ASCOM [nucleoplasm] (Homo sapiens)
as a member of
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
Inferred To
CYC8 [nucleoplasm]
(Saccharomyces cerevisiae)
KDM6A [nucleoplasm]
(Bos taurus)
KDM6A [nucleoplasm]
(Canis familiaris)
KDM6A [nucleoplasm]
(Gallus gallus)
KDM6A [nucleoplasm]
(Sus scrofa)
Utx [nucleoplasm]
(Drosophila melanogaster)
utx-1 [nucleoplasm]
(Caenorhabditis elegans)
trfA [nucleoplasm]
(Dictyostelium discoideum)
kdm6a [nucleoplasm]
(Xenopus tropicalis)
ssn6 [nucleoplasm]
(Schizosaccharomyces pombe)
Kdm6a [nucleoplasm]
(Mus musculus)
Kdm6a [nucleoplasm]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2684
ENSEMBL
ENSP00000367203
,
ENST00000377967
,
ENSG00000147050
OpenTargets
ENSG00000147050
ZINC - Substances
KDM6A_HUMAN
ZINC target
O15550
PRO
O15550
GlyGen
O15550
PDB
6FUL
,
3AVR
,
6FUK
,
3AVS
IntEnz
1.14.11.68
GeneCards
KDM6A
HPA
ENSG00000147050-KDM6A
Pharos - Targets
O15550
Orphanet
KDM6A
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.773
7
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.725
8
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.725
6
UniProt:Q9BTK6 PAGR1
1
PAGR1 [nucleoplasm]
(R-HSA-5619374)
0.725
4
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.69
6
UniProt:Q6ZW49 PAXIP1
1
PAXIP1 [nucleoplasm]
(R-HSA-5619395)
0.643
8
UniProt:O15499 GSC2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.536
2
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.536
2
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.527
7
UniProt:Q9C005 DPY30
1
DPY30 [nucleoplasm]
(R-HSA-5669104)
0.527
2
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