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p-S172-IKBKE [nucleoplasm]
Stable Identifier
R-HSA-4755521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
IKKE-P, Inhibitor of nuclear factor kappa-B kinase epsilon subunit
Icon
Locations in the PathwayBrowser for interactor UniProt:P19105 MYL12A
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of immune response proteins (Homo sapiens)
TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)
p-S172-IKBKE [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14164 IKBKE
Gene Names
IKBKE, IKKE, IKKI, KIAA0151
Chain
chain:1-716
Reference Genes
BioGPS Gene:9641 IKBKE
COSMIC (genes):IKBKE IKBKE
CTD Gene:9641 IKBKE
dbSNP Gene:9641 IKBKE
ENSEMBL:ENSG00000263528 IKBKE
HGNC:14552 IKBKE
KEGG:hsa:9641 IKBKE
Monarch:9641 IKBKE
NCBI Gene:9641 IKBKE
OMIM:605048 IKBKE
UCSC:Q14164 IKBKE
Reference Transcript
RefSeq:NM_014002.3 IKBKE
RefSeq:NM_001193322.1 IKBKE
RefSeq:XM_005273356.2 IKBKE
RefSeq:NM_001193321.1 IKBKE
Other Identifiers
11720956_a_at
11720957_a_at
16676592
204549_PM_at
204549_at
214398_PM_s_at
214398_s_at
2376798
2376800
2376801
2376802
2376806
2376807
2376808
2376809
2376810
2376811
2376812
2376813
2376814
2376815
2376816
2376817
2376818
2376819
2376820
2376821
2376822
2376823
2376824
2376825
2376826
2376830
2376831
2376832
2376833
2376835
2376836
2376837
2376838
2376839
2376840
33281_at
7909188
9641
A_14_P131795
A_23_P887
D63485_at
GE61317
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006468
GO:0006955
GO:0006974
GO:0008384
GO:0008630
GO:0010467
GO:0010628
GO:0010884
GO:0016605
GO:0016740
GO:0019903
GO:0031625
GO:0031966
GO:0032481
GO:0034340
GO:0035456
GO:0036435
GO:0042802
GO:0043123
GO:0043226
GO:0043254
GO:0048255
GO:0051091
GO:0051607
GO:0060337
GO:0060340
GO:0097400
GO:0098542
GO:0098586
GO:0140096
GO:1902554
HMNXSV003030390
HMNXSV003051390
Hs.321045.1.S1_3p_a_at
Hs.321045.1.S1_3p_x_at
ILMN_1755024
PH_hs_0016042
TC01001723.hg
g7661945_3p_at
Participates
as an input of
TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)
Other forms of this molecule
IKBKE [cytosol]
p-S172-IKBKE [cytosol]
K63polyUb-K30,K401-IKBKE [cytosol]
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
Inferred To
phospho-p-S172-IKBKE [nucleoplasm]
(Bos taurus)
phospho-p-S172-IKBKE [nucleoplasm]
(Danio rerio)
phospho-p-S172-IKBKE [nucleoplasm]
(Gallus gallus)
phospho-p-S172-IKBKE [nucleoplasm]
(Mus musculus)
phospho-p-S172-IKBKE [nucleoplasm]
(Sus scrofa)
phospho-p-S172-IKBKE [nucleoplasm]
(Xenopus tropicalis)
phospho-Ikbke [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 172
Coordinate
172
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001180251.1
,
NP_001180250.1
,
NP_054721.1
,
XP_005273413.1
ZINC - World Drugs
IKKE_HUMAN
Guide to Pharmacology - Targets
2040
ENSEMBL
ENST00000584998
,
ENST00000581977
,
ENSP00000464030
,
ENSP00000462396
OpenTargets
ENSG00000263528
ZINC - FDA approved
IKKE_HUMAN
ZINC - Substances
IKKE_HUMAN
ZINC - Biogenic
IKKE_HUMAN
ZINC target
Q14164
PRO
Q14164
ZINC - Investigational
IKKE_HUMAN
IntEnz
2.7.11.10
HPA
ENSG00000263528-IKBKE
Pharos - Targets
Q14164
ZINC - Predictions - Purchasable
IKKE_HUMAN
HMDB Protein
HMDBP09508
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92844 TANK
2
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
TANK [cytosol]
(R-HSA-933407)
0.829
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.77
4
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.77
4
UniProt:A7MCY6 TBKB1
0.723
4
UniProt:O00571 DDX3X
3
DDX3X [secretory granule lumen]
(R-HSA-6801275)
DDX3X [extracellular region]
(R-HSA-6806507)
DDX3X [ficolin-1-rich granule lumen]
(R-HSA-6801273)
0.697
4
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.675
4
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.669
3
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.669
5
UniProt:Q05127 VP35
0.602
3
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.589
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.589
3
UniProt:P19105 MYL12A
2
p-S19-MYL12A [cytosol]
(R-HSA-390749)
MYL12A [cytosol]
(R-HSA-390735)
0.589
2
UniProt:P35580 MYH10
1
MYH10 [cytosol]
(R-HSA-419174)
0.589
2
UniProt:Q00610 CLTC
10
CLTC [trans-Golgi network membrane]
(R-HSA-5333703)
CLTC [cytosol]
(R-HSA-8856820)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710852)
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710854)
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9710835)
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710853)
CLTC [endolysosome membrane]
(R-HSA-8870827)
CLTC [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138450)
CLTC [lysosomal membrane]
(R-HSA-2980660)
CLTC [plasma membrane]
(R-HSA-2980668)
0.589
2
UniProt:P62158 CALM
0.589
2
UniProt:P06753 TPM3
3
TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710848)
TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710837)
TPM3 [cytosol]
(R-HSA-390543)
0.589
2
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.589
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.564
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.564
2
UniProt:Q14653 IRF3
6
IRF3 [cytosol]
(R-HSA-166251)
IRF3(2-271) [cytosol]
(R-HSA-9729696)
IRF3(272-427) [cytosol]
(R-HSA-9729737)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
0.544
2
UniProt:K7Y1A2 K7Y1A2
0.524
2
UniProt:P27958-PRO_0000037572
0.524
2
UniProt:Q9BYX4 IFIH1
3
IFIH1 [cytosol]
(R-HSA-913536)
K48polyUb-IFIH1 [cytosol]
(R-HSA-3080557)
PolyUb-IFIH1 [cytosol]
(R-HSA-6782812)
0.499
2
UniProt:Q92624 APBP2
0.499
4
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.463
2
UniProt:W5VXH5 W5VXH5
0.463
4
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