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SUMOylation of NR1I2 with SUMO3
Stable Identifier
R-HSA-4755524
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of NR1I2 with SUMO3 (Homo sapiens)
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NR1I2 (Pregnane X Receptor, PXR) is SUMOylated with SUMO3 (Hu et al. 2010). SUMOylation is stimulated when NR1I2 binds ligand (rifampicin) and causes NR1I2 to transrepress genes encoding inflammatory cytokines.
Literature References
PubMed ID
Title
Journal
Year
20719936
Pregnane X receptor is SUMOylated to repress the inflammatory response
Hu, G
,
Staudinger, JL
,
Xu, C
J. Pharmacol. Exp. Ther.
2010
Participants
Input
NR1I2:rifampicin [nucleoplasm]
(Homo sapiens)
x 2
SUMO3:UBE2I [nucleoplasm]
(Homo sapiens)
Output
SUMO3-NR1I2:rifampicin [nucleoplasm]
(Homo sapiens)
x 2
UBE2I [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SUMOylation of intracellular receptors (Homo sapiens)
Orthologous Events
SUMOylation of NR1I2 with SUMO3 (Bos taurus)
SUMOylation of NR1I2 with SUMO3 (Danio rerio)
SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)
SUMOylation of NR1I2 with SUMO3 (Mus musculus)
SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)
SUMOylation of NR1I2 with SUMO3 (Sus scrofa)
Authored
May, B (2013-10-20)
Reviewed
Niskanen, E (2018-05-09)
Niskanen, E (2018-08-08)
Created
May, B (2013-10-25)
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