Reactome | monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]

monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]

Stable Identifier

R-HSA-4755535

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

IKKE-P, Inhibitor of nuclear factor kappa-B kinase epsilon subunit

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Locations in the PathwayBrowser for interactor UniProt:P19105 MYL12A

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External Reference Information

External Reference

UniProt:Q14164 IKBKE

Gene Names

IKBKE, IKKE, IKKI, KIAA0151

Chain

chain:1-716

Reference Genes

BioGPS Gene:9641 IKBKE

COSMIC (genes):IKBKE IKBKE

CTD Gene:9641 IKBKE

dbSNP Gene:9641 IKBKE

ENSEMBL:ENSG00000263528 IKBKE

HGNC:14552 IKBKE

KEGG:hsa:9641 IKBKE

Monarch:9641 IKBKE

NCBI Gene:9641 IKBKE

OMIM:605048 IKBKE

UCSC:Q14164 IKBKE

Reference Transcript

Other Identifiers

11720956_a_at

11720957_a_at

16676592

204549_PM_at

204549_at

214398_PM_s_at

214398_s_at

2376798

2376800

2376801

2376802

2376806

2376807

2376808

2376809

2376810

2376811

2376812

2376813

2376814

2376815

2376816

2376817

2376818

2376819

2376820

2376821

2376822

2376823

2376824

2376825

2376826

2376830

2376831

2376832

2376833

2376835

2376836

2376837

2376838

2376839

2376840

33281_at

7909188

9641

A_14_P131795

A_23_P887

D63485_at

GE61317

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0006955

GO:0006974

GO:0008384

GO:0008630

GO:0010467

GO:0010628

GO:0010884

GO:0016605

GO:0016740

GO:0019903

GO:0031625

GO:0031966

GO:0032481

GO:0034340

GO:0035456

GO:0036435

GO:0042802

GO:0043123

GO:0043226

GO:0043254

GO:0048255

GO:0051091

GO:0051607

GO:0060337

GO:0060340

GO:0097400

GO:0098542

GO:0098586

GO:0140096

GO:1902554

HMNXSV003030390

HMNXSV003051390

Hs.321045.1.S1_3p_a_at

Hs.321045.1.S1_3p_x_at

ILMN_1755024

PH_hs_0016042

TC01001723.hg

g7661945_3p_at

Participates

as an output of

TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)

Other forms of this molecule

IKBKE [cytosol]

p-S172-IKBKE [cytosol]

K63polyUb-K30,K401-IKBKE [cytosol]

p-S172-IKBKE [nucleoplasm]

Inferred To

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Bos taurus)

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Danio rerio)

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Gallus gallus)

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Mus musculus)

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Sus scrofa)

phospho-monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (Xenopus tropicalis)

phospho-Ikbke [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 172

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 231

Coordinate

231

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001180251.1, NP_001180250.1, NP_054721.1, XP_005273413.1

ZINC - World Drugs

IKKE_HUMAN

Guide to Pharmacology - Targets

2040

ENSEMBL

ENST00000584998, ENST00000581977, ENSP00000464030, ENSP00000462396

OpenTargets

ENSG00000263528

ZINC - FDA approved

IKKE_HUMAN

ZINC - Substances

IKKE_HUMAN

ZINC - Biogenic

IKKE_HUMAN

ZINC target

Q14164

PRO

Q14164

ZINC - Investigational

IKKE_HUMAN

IntEnz

2.7.11.10

HPA

ENSG00000263528-IKBKE

Pharos - Targets

Q14164

ZINC - Predictions - Purchasable

IKKE_HUMAN

HMDB Protein

HMDBP09508

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.829	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.77	4
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.77	4
UniProt:A7MCY6 TBKB1			0.723	4
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.697	4
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.675	4
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.669	3
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.669	5
UniProt:Q05127 VP35			0.602	3
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.589	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.589	3
UniProt:P19105 MYL12A	2	p-S19-MYL12A [cytosol] (R-HSA-390749) MYL12A [cytosol] (R-HSA-390735)	0.589	2
UniProt:P35580 MYH10	1	MYH10 [cytosol] (R-HSA-419174)	0.589	2
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [plasma membrane] (R-HSA-2980668)	0.589	2
UniProt:P62158 CALM			0.589	2
UniProt:P06753 TPM3	3	TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3 [cytosol] (R-HSA-390543)	0.589	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.589	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.564	2
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.564	2
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.544	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.499	2
UniProt:Q92624 APBP2			0.499	4
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	2
UniProt:W5VXH5 W5VXH5			0.463	4

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