PIAS3 SUMOylates RELA with SUMO3

Stable Identifier
R-HSA-4755536
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.
Literature References
PubMed ID Title Journal Year
22649547 NF-?B repression by PIAS3 mediated RelA SUMOylation

Kulesz-Martin, M, Liu, Y, Wortham, A, Bridges, R

PLoS ONE 2012
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS3 [nucleoplasm]

Orthologous Events
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