MAPKAPK2 phosphorylates HSF1

Stable Identifier
R-HSA-4793911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding
Literature References
PubMed ID Title Journal Year
16278218 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

Wang, X, Zhao, MJ, Gaestel, M, Zhong, R, Calderwood, SK, Khaleque, MA

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of MAPKAPK2 [cytosol]

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