MAPKAPK2 phosphorylates HSF1

Stable Identifier
R-HSA-4793911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAPKAPK2 phosphorylates HSF1
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Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding

Literature References
PubMed ID Title Journal Year
16278218 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

Wang, X, Zhao, MJ, Gaestel, M, Zhong, R, Calderwood, SK, Khaleque, MA

J. Biol. Chem. 2006
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Catalyst Activity

protein serine/threonine kinase activity of MAPKAPK2 [cytosol]

Physical Entity
MAPKAPK2 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAPKAPK2 phosphorylates HSF1 (Bos taurus)
MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)
MAPKAPK2 phosphorylates HSF1 (Danio rerio)
MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)
MAPKAPK2 phosphorylates HSF1 (Gallus gallus)
MAPKAPK2 phosphorylates HSF1 (Mus musculus)
MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)
MAPKAPK2 phosphorylates HSF1 (Sus scrofa)
Authored
Shamovsky, V  (2013-10-29)
Reviewed
Pani, B  (2014-02-17)
Created
Shamovsky, V  (2013-10-29)
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