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REST [nucleoplasm]
Stable Identifier
R-HSA-480506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RE1-silencing transcription factor, REST_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
Regulation of NPAS4 gene expression (Homo sapiens)
Regulation of NPAS4 gene transcription (Homo sapiens)
NPAS4 gene transcription in non-neuronal cells is repressed by REST (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
REST:NPAS4 gene [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
REST:NPAS4 gene [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
REST binds the VGF promoter (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
VGF gene:REST [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
VGF gene expression (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
VGF gene:REST [nucleoplasm] (Homo sapiens)
REST [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13127 REST
Gene Names
REST, NRSF, XBR
Chain
chain:1-1097
Reference Genes
BioGPS Gene:5978 REST
COSMIC (genes):REST REST
CTD Gene:5978 REST
dbSNP Gene:5978 REST
ENSEMBL:ENSG00000084093 REST
HGNC:9966 REST
KEGG:hsa:5978 REST
Monarch:5978 REST
NCBI Gene:5978 REST
OMIM:600571 REST
UCSC:Q13127 REST
Reference Transcript
RefSeq:NM_005612.4 REST
RefSeq:NM_001193508.1 REST
RefSeq:XM_011534401.2 REST
Other Identifiers
11736657_a_at
11755395_a_at
16967091
204535_PM_s_at
204535_s_at
212920_PM_at
212920_at
2728410
2728411
2728412
2728413
2728414
2728415
2728416
2728417
2728418
2728419
2728422
2728423
2728424
2728425
2728426
2728427
2728428
2728429
2728430
2728431
3423798
5978
62194_at
8095262
86901_at
86903_g_at
A_14_P109194
A_14_P135173
A_23_P167081
A_24_P246787
GE81533
GE88088
GO:0000122
GO:0000381
GO:0000976
GO:0000978
GO:0000979
GO:0001227
GO:0001666
GO:0002244
GO:0002931
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006355
GO:0008285
GO:0010468
GO:0010629
GO:0017053
GO:0030154
GO:0032348
GO:0034330
GO:0035019
GO:0043065
GO:0043068
GO:0043226
GO:0043280
GO:0043565
GO:0043922
GO:0045665
GO:0045666
GO:0045667
GO:0045892
GO:0045893
GO:0045944
GO:0045955
GO:0046676
GO:0046872
GO:0050768
GO:0050877
GO:0060379
GO:0061629
GO:0071257
GO:0071385
GO:0071466
GO:0097150
GO:0099563
GO:0140110
GO:1902459
GO:1902894
GO:2000065
GO:2000706
GO:2000740
GO:2000798
HMNXSV003035505
Hs.227630.0.S1_3p_a_at
Hs.227630.1.S1_3p_at
ILMN_1727107
PH_hs_0019087
TC04000335.hg
U22314_s_at
Participates
as a component of
REST:NPAS4 gene [nucleoplasm] (Homo sapiens)
VGF gene:REST [nucleoplasm] (Homo sapiens)
CoREST complex [nucleoplasm] (Homo sapiens)
as an input of
REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)
REST binds the VGF promoter (Homo sapiens)
Inferred To
RESTA [nucleoplasm]
(Bos taurus)
Rest [nucleoplasm]
(Mus musculus)
Rest [nucleoplasm]
(Rattus norvegicus)
Dmel\CG8388 [nucleoplasm]
(Drosophila melanogaster)
Homologues of REST [nucleoplasm]
(Drosophila melanogaster)
rest [nucleoplasm]
(Danio rerio)
rest [nucleoplasm]
(Xenopus tropicalis)
REST [nucleoplasm]
(Canis familiaris)
REST [nucleoplasm]
(Drosophila melanogaster)
REST [nucleoplasm]
(Sus scrofa)
Ghost homologue of REST [nucleoplasm]
(Gallus gallus)
mep-1 [nucleoplasm]
(Caenorhabditis elegans)
Dmel\CG4282 [nucleoplasm]
(Drosophila melanogaster)
Cg4707 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011532703.1
,
NP_005603.3
,
NP_001180437.1
ENSEMBL
ENSP00000311816
,
ENST00000675105
,
ENST00000309042
,
ENSP00000502313
OpenTargets
ENSG00000084093
HPA
ENSG00000084093-REST
PRO
Q13127
Pharos - Targets
Q13127
GlyGen
Q13127
Orphanet
REST
PDB
6DU3
,
6DU2
,
2CZY
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.766
10
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.623
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.57
4
UniProt:P41229 KDM5C
1
KDM5C [nucleoplasm]
(R-HSA-4754186)
0.558
3
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