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Synthesis of dolichyl-phosphate-glucose
Stable Identifier
R-HSA-480985
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
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Dolichyl-phosphate-glucose functions as a donor of glucose groups in reactions including three steps of N-glycan precursor biosynthesis. Dolichyl-phosphate-glucose itself is synthesized from UDP-glucose and dolichol phosphate on the cytosolic face of the endoplasmic reticulum membrane, then flipped to the luminal surface of that membrane.
Participants
Events
NUDT14 hydrolyses UDP-Glc to G1P and UMP
(Homo sapiens)
Synthesis of dolichyl-phosphate-glucose
(Homo sapiens)
Flipping of dolichyl-phosphate-glucose into the ER lumen
(Homo sapiens)
Participates
as an event of
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Event Information
Go Biological Process
protein N-linked glycosylation via asparagine (0018279)
Orthologous Events
Synthesis of dolichyl-phosphate-glucose (Bos taurus)
Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)
Synthesis of dolichyl-phosphate-glucose (Canis familiaris)
Synthesis of dolichyl-phosphate-glucose (Danio rerio)
Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)
Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)
Synthesis of dolichyl-phosphate-glucose (Gallus gallus)
Synthesis of dolichyl-phosphate-glucose (Mus musculus)
Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)
Synthesis of dolichyl-phosphate-glucose (Saccharomyces cerevisiae)
Synthesis of dolichyl-phosphate-glucose (Schizosaccharomyces pombe)
Synthesis of dolichyl-phosphate-glucose (Sus scrofa)
Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)
Authored
Dall'Olio, GM (2009-11-10)
Reviewed
Gagneux, P (2010-04-16)
Created
Jassal, B (2010-01-27)
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