Reactome | Secretion of SOD3

Secretion of SOD3

Stable Identifier

R-HSA-4837364

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi lumen, extracellular region

ReviewStatus

5/5

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SOD3 is secreted from cells into the extracellular region. Before secretion a portion of SOD3 molecules are cleaved near the C-terminus at glutamate-227 (glutamate-209 in the mature protein) (Olsen et al. 2004, Karlsson et al. 1993). Removal of the C-terminus prevents interaction with the extracellular matrix so cleaved molecules are soluble. Cleaved and uncleaved molecules are believed to be capable of forming mixed tetramers (Sandstrom et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8452552	Proteolytic modification of the heparin-binding affinity of extracellular superoxide dismutase Karlsson, K, Sandström, J, Edlund, A, Marklund, SL	Biochem. J.	1993
15044467	The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event Thøgersen, IB, Petersen, SV, Valnickova, Z, Kristensen, T, Oury, TD, Enghild, JJ, Crapo, JD, Bowler, RP, Olsen, DA	J. Biol. Chem.	2004
8379940	Heparin-affinity patterns and composition of extracellular superoxide dismutase in human plasma and tissues Edlund, T, Karlsson, K, Sandström, J, Marklund, SL	Biochem. J.	1993