AXIN1 Y346* [cytosol]

Stable Identifier
R-HSA-4839753
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
AXIN1 Y346* [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
10700176 AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Miwa, N, Tokino, T, Furukawa, Y, Fujita, M, Daigo, Y, Nishiwaki, T, Nakamura, Y, Kato, T, Satoh, S, Kawasoe, T, Yamaoka, Y, Murata, M, Sasaki, Y, Ishiguro, H, Shimano, T, Imaoka, S

Nat. Genet. 2000
Participates
Other forms of this molecule
Modified Residues
Name
Nonsense mutation at L-tyrosine 346
Coordinate
346
PsiMod
A protein modification that effectively removes or replaces an L-tyrosine.
Disease
Name Identifier Synonyms
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
COSMIC
OpenTargets
GeneCards
PRO
Pharos - Targets
Orphanet
HMDB Protein
Interactors (65)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P49841 GSK3B  4 0.976 52
 UniProt:P35222 CTNNB1  20 0.94 44
 UniProt:P25054 APC  20 0.845 17
 UniProt:P49840 GSK3A  3 0.802 6
 UniProt:O15169 AXIN1  11 0.782 5
 UniProt:Q5JTC6 AMER1  5 0.708 7
 UniProt:P49674 CSNK1E  2 0.687 5
 UniProt:P14923 JUP  6 0.666 4
 UniProt:P67775 PPP2CA  4 0.643 4
 UniProt:P48729 CSNK1A1  2 0.643 4
 UniProt:Q9H7D7 WDR26  1 0.641 4
 UniProt:P01106 MYC  2 0.623 10
 UniProt:O14641 DVL2  5 0.59 3
 UniProt:Q9UKB1 FBXW11  1 0.558 4
 UniProt:Q7Z699 SPRED1  2 0.556 3
 UniProt:Q9BQ66 KR412      0.556 3
 UniProt:Q99750 MDFI      0.556 3
 UniProt:Q96KG9-4 SCYL1      0.556 3
 UniProt:O94972 TRIM37  1 0.556 3
 UniProt:Q9C019 TRI15      0.556 3
 UniProt:Q9UJV3-2 MID2      0.556 3
 UniProt:Q969G2 LHX4  1 0.556 3
 UniProt:O15105 SMAD7  2 0.556 8
 IntAct:EBI-16436498 CCSB ORF ID      0.556 3
 UniProt:Q9BYR5 KRTAP4-2  1 0.556 3
 UniProt:Q9H257-2 CARD9      0.556 3
 UniProt:Q13137 CACO2      0.556 3
 UniProt:Q5JR59-3 MTUS2      0.556 3
 UniProt:Q12933 TRAF2  5 0.556 3
 UniProt:O43586 PSTPIP1  1 0.556 3
 IntAct:EBI-16436244 CCSB ORF ID      0.556 3
 IntAct:EBI-16434222 CCSB ORF ID      0.556 3
 UniProt:O75558 STX11      0.556 3
 UniProt:Q96K21-3 ZFYVE19      0.556 3
 UniProt:Q2TAC2-2 CCDC57      0.556 3
 IntAct:EBI-16437007 CCSB ORF ID      0.556 3
 UniProt:Q9UBB9 TFIP11  1 0.556 3
 IntAct:EBI-16429620 CCSB ORF ID      0.556 3
 UniProt:Q15654 TRIP6      0.556 6
 UniProt:P14373 TRIM27  2 0.556 3
 UniProt:Q08379 GOLGA2  3 0.556 3
 UniProt:Q6A162 KRT40  1 0.556 3
 UniProt:Q6FHY5 Q6FHY5      0.556 3
 UniProt:P63165 SUMO1  11 0.556 3
 UniProt:G2XKQ0 SUMO5      0.556 3
 UniProt:Q9HCK0 ZBT26      0.556 3
 UniProt:Q15172 PPP2R5A  2 0.527 2
 UniProt:O75581 LRP6  8 0.527 9
 UniProt:Q93008 USP9X  1 0.527 2
 IntAct:EBI-11789122 GSK3A      0.525 2
 UniProt:G1T8E2 G1T8E2      0.525 2
 UniProt:Q92837 FRAT1  1 0.525 3
 UniProt:Q5VWQ8-2 DAB2IP      0.524 2
 UniProt:P04637 TP53  20 0.524 4
 UniProt:P62136 PPP1CA  1 0.524 4
 UniProt:P23258 TUBG1  1 0.512 4
 UniProt:Q14194 CRMP1  4 0.508 2
 UniProt:P39687 ANP32A  1 0.508 2
 UniProt:P49407 ARRB1  6 0.499 2
 UniProt:P46937 YAP1  8 0.499 11
 UniProt:P35813 PPM1A  2 0.499 2
 UniProt:Q15583 TGIF1  1 0.499 4
 UniProt:Q60953-2 PML      0.499 2
 UniProt:Q99ML9 Rnf111  3 0.463 5
 UniProt:P29590 PML  5 0.463 2
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