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A2M [extracellular region]
Stable Identifier
R-HSA-49291
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Alpha-2-macroglobulin, Alpha-2-M
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
A2M tetramer [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
A2M tetramer [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)
A2M tetramer [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
kallikrein:alpha2-macroglobulin [extracellular region] (Homo sapiens)
A2M tetramer [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
HDL assembly (Homo sapiens)
BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Homo sapiens)
A2M tetramer [extracellular region] (Homo sapiens)
A2M [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01023 A2M
Gene Names
A2M, CPAMD5, FWP007
Chain
signal peptide:1-23, chain:24-1474
Reference Genes
BioGPS Gene:2 A2M
COSMIC (genes):A2M A2M
CTD Gene:2 A2M
dbSNP Gene:2 A2M
ENSEMBL:ENSG00000175899 A2M
HGNC:7 A2M
KEGG:hsa:2 A2M
Monarch:2 A2M
NCBI Gene:2 A2M
OMIM:103950 A2M
UCSC:P01023 A2M
Reference Transcript
RefSeq:NM_001347425.1 A2M
RefSeq:NM_000014.6 A2M
RefSeq:NM_001347423.2 A2M
RefSeq:NM_001347424.1 A2M
Other Identifiers
11715363_a_at
16761012
2
217757_PM_at
217757_at
3443350
3443351
3443352
3443353
3443354
3443355
3443356
3443357
3443358
3443362
3443365
3443366
3443367
3443368
3443369
3443370
3443374
3443375
3443376
3443377
3443378
3443379
3443380
3443381
3443382
3443383
3443385
3443386
3443387
3443388
3443389
3443390
3443392
3443393
3443395
3443396
3443397
3443399
3443400
3443402
3443403
3443405
3443406
3443407
3443409
3443410
3443411
3443412
3443413
3443414
3443415
3443416
3443417
3443418
3443419
3443420
3443421
3443422
3443424
3443425
3443426
3443428
3443429
3443431
3443432
3443433
72229_i_at
72231_r_at
74536_i_at
74537_f_at
75187_f_at
7960947
A_23_P116898
GE57808
GO:0001869
GO:0002020
GO:0004866
GO:0004867
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0019838
GO:0019899
GO:0019959
GO:0019966
GO:0030154
GO:0030312
GO:0030414
GO:0031012
GO:0031093
GO:0043120
GO:0048306
GO:0048863
GO:0070062
GO:0072562
GO:0098772
HMNXSV003014414
ILMN_1745607
M11313_s_at
PH_hs_0041025
TC12001187.hg
Participates
as a component of
A2M tetramer [extracellular region] (Homo sapiens)
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Other forms of this molecule
A2M [platelet alpha granule lumen]
Inferred To
A2M [extracellular region]
(Canis familiaris)
A2M [extracellular region]
(Sus scrofa)
a2m3g [extracellular region]
(Danio rerio)
Homologues of A2M [extracellular region]
(Danio rerio)
A2m [extracellular region]
(Mus musculus)
A2m [extracellular region]
(Rattus norvegicus)
LOC100489060 [extracellular region]
(Xenopus tropicalis)
A2ML3 [extracellular region]
(Gallus gallus)
a2m3b [extracellular region]
(Danio rerio)
a2m3h [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001334353.1
,
NP_001334352.2
,
NP_001334354.1
,
NP_000005.3
OpenTargets
ENSG00000175899
ENSEMBL
ENST00000318602
,
ENSG00000175899
,
ENSP00000323929
HPA
ENSG00000175899-A2M
GeneCards
A2M
PRO
P01023
Pharos - Targets
P01023
GlyGen
P01023
HMDB Protein
HMDBP02061
PDB
7O7N
,
7O7M
,
7O7R
,
1BV8
,
6TAV
,
7O7P
,
7O7L
,
7O7Q
,
7O7O
,
2P9R
,
7VOO
,
7VON
,
7O7S
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NBL1 POGLUT1
1
POGLUT1 [endoplasmic reticulum lumen]
(R-HSA-1464796)
0.643
3
UniProt:Q9NWM8 FKBP14
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.643
3
UniProt:Q8WVJ9 TWIST2
1
TWIST2 [nucleoplasm]
(R-HSA-445444)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
0.556
3
UniProt:P10599 TXN
4
TXN [cytosol]
(R-HSA-66000)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:P07948 LYN
7
LYN [cytosol]
(R-HSA-354251)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
LYN [plasma membrane]
(R-HSA-197943)
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:Q9H147 DNTTIP1
1
DNTTIP1 [nucleoplasm]
(R-HSA-9815865)
0.556
3
UniProt:Q9ULV1 FZD4
3
ub-FZD4 [plasma membrane]
(R-HSA-4641182)
FZD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138457)
FZD4 [plasma membrane]
(R-HSA-443956)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:P04141 CSF2
1
CSF2 [extracellular region]
(R-HSA-517562)
0.556
3
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.556
3
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