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What is Reactome ?
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LIN28A [cytosol]
Stable Identifier
R-HSA-500391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Lin-28 homolog A, LN28A_HUMAN, LIN28
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)
LIN28:POU5F1 mRNA [cytosol] (Homo sapiens)
LIN28A [cytosol] (Homo sapiens)
LIN28A [cytosol] (Homo sapiens)
Translation of OCT4 mRNA (Homo sapiens)
LIN28:POU5F1 mRNA [cytosol] (Homo sapiens)
LIN28A [cytosol] (Homo sapiens)
LIN28A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H9Z2 LIN28A
Gene Names
LIN28A, CSDD1, LIN28, ZCCHC1
Chain
initiator methionine:, chain:2-209
Reference Genes
BioGPS Gene:79727 LIN28A
COSMIC (genes):LIN28A LIN28A
CTD Gene:79727 LIN28A
dbSNP Gene:79727 LIN28A
ENSEMBL:ENSG00000131914 LIN28A
ENSEMBL_homo_sapiens_GENE:ENSG00000131914.11 LIN28A
HGNC:15986 LIN28A
KEGG Gene (Homo sapiens):79727 LIN28A
Monarch:79727 LIN28A
NCBI Gene:79727 LIN28A
OMIM:611043 LIN28A
UCSC:Q9H9Z2 LIN28A
Reference Transcript
RefSeq:XM_011542148.1 LIN28A
RefSeq:NM_024674.5 LIN28A
Other Identifiers
11725430_at
16661155
219823_PM_at
219823_at
2326486
2326487
2326489
2326490
2326491
2326492
2326493
2326494
2326495
2326497
2326498
2326499
2326500
2326501
2326502
2518805
3371883
62956_at
7899167
79727
91330_at
A_23_P74895
GE86917
GE88684
GO:0000932
GO:0002151
GO:0002181
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005783
GO:0005791
GO:0005829
GO:0007281
GO:0008270
GO:0010494
GO:0010586
GO:0010587
GO:0010629
GO:0017148
GO:0019827
GO:0022414
GO:0023052
GO:0030154
GO:0031047
GO:0031054
GO:0031123
GO:0031369
GO:0032008
GO:0035198
GO:0043226
GO:0045666
GO:0045686
GO:0045727
GO:0046872
GO:0048856
GO:0048863
GO:0051897
GO:0060090
GO:0060964
GO:0070883
GO:0071076
GO:0071333
GO:0140517
GO:1901724
GO:1905538
GO:1990825
GO:2000632
GO:2000767
HMNXSV003054545
ILMN_1748903
PH_hs_0004853
TC01000343.hg
g13375937_3p_at
Participates
as an input of
LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)
as a component of
LIN28:POU5F1 mRNA [cytosol] (Homo sapiens)
Inferred To
LIN28A [cytosol]
(Bos taurus)
LIN28A [cytosol]
(Caenorhabditis elegans)
LIN28A [cytosol]
(Canis familiaris)
LIN28A [cytosol]
(Danio rerio)
LIN28A [cytosol]
(Drosophila melanogaster)
LIN28A [cytosol]
(Gallus gallus)
LIN28A [cytosol]
(Sus scrofa)
LIN28A [cytosol]
(Xenopus tropicalis)
Lin28a [cytosol]
(Mus musculus)
Lin28a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_078950.1
,
XP_011540450.1
OpenTargets
ENSG00000131914
GeneCards
Q9H9Z2
HPA
ENSG00000131914-LIN28A
Ensembl
ENST00000254231
,
ENSP00000363314
,
ENSG00000131914
,
ENST00000326279
,
ENSP00000254231
PRO
Q9H9Z2
Pharos - Targets
Q9H9Z2
HMDB Protein
HMDBP10913
PDB
5UDZ
,
2CQF
,
2LI8
Interactors (135)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.643
3
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.643
4
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.643
4
UniProt:O00425 IGF2BP3
1
IGF2BP3 [cytosol]
(R-HSA-428313)
0.643
3
UniProt:P62899 RPL31
1
RPL31 [cytosol]
(R-HSA-72454)
0.643
4
UniProt:Q5TAX3 ZCCHC11
1
TUT4 [cytosol]
(R-HSA-8941307)
0.558
2
IntAct:EBI-25865403 EHD27213144
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9NSD4 ZN275
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:O15371 EIF3D
1
EIF3D [cytosol]
(R-HSA-72548)
0.547
5
UniProt:O76021 RL1D1
0.527
2
UniProt:P16403 H1-2
1
HIST1H1C [nucleoplasm]
(R-HSA-211237)
0.527
2
UniProt:P82673 MRPS35
1
MRPS35 [mitochondrial inner membrane]
(R-HSA-5368185)
0.527
2
UniProt:Q9HCE1 MOV10
1
MOV10 [cytosol]
(R-HSA-427772)
0.527
3
UniProt:Q96JP5 ZFP91
0.527
2
UniProt:P68363 TUBA1B
9
AcK-TUBA1B [cytosol]
(R-HSA-5618285)
Ac K40 TUBA1B [axonemal microtubule]
(R-HSA-5624854)
TUBA1B folding intermediate [cytosol]
(R-HSA-392797)
TUBA1B unfolded [cytosol]
(R-HSA-392781)
L-isoglutamyl polyglycyl-TUBA1B [cytosol]
(R-HSA-8867436)
Polyglutamyl-TUBA1B [cytosol]
(R-HSA-8867435)
TUBA1B(1-450) [cytosol]
(R-HSA-8955581)
TUBA1B [axonemal microtubule]
(R-HSA-5610434)
TUBA1B [cytosol]
(R-HSA-191691)
0.527
2
UniProt:Q8N9T8 KRI1
0.527
3
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
2
UniProt:Q9H7E9 CH033
0.527
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.527
2
UniProt:Q7Z2W4 ZC3HAV1
2
ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]
(R-HSA-6802506)
ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol]
(R-HSA-6802557)
0.527
3
UniProt:Q99848 EBNA1BP2
1
EBNA1BP2 [nucleoplasm]
(R-HSA-8869325)
0.527
2
UniProt:Q9BZE4 GTPB4
0.527
2
UniProt:Q5VWQ0 RSBN1
0.527
3
UniProt:Q9H2U1 DHX36
1
DHX36 [cytosol]
(R-HSA-3134862)
0.527
2
UniProt:Q9Y3D3 MRPS16
1
MRPS16 [mitochondrial inner membrane]
(R-HSA-5368229)
0.527
2
UniProt:P10412 H1-4
1
HIST1H1E [nucleoplasm]
(R-HSA-211251)
0.527
2
UniProt:O96028 NSD2
2
p-S102-WHSC1 [nucleoplasm]
(R-HSA-5682984)
WHSC1 [nucleoplasm]
(R-HSA-1183215)
0.527
2
UniProt:Q9H8H2 DDX31
0.527
2
UniProt:Q13823 NOG2
0.527
2
UniProt:Q16777 H2AC20
13
K63polyUb-HIST2H2AC [nucleoplasm]
(R-HSA-6783299)
Ub-HIST2H2AC [nucleoplasm]
(R-HSA-6782532)
AcK6-HIST2H2AC [nucleoplasm]
(R-HSA-4568572)
Me2aR30-HIST2H2AC [nucleoplasm]
(R-HSA-5244562)
MeR30-HIST2H2AC [nucleoplasm]
(R-HSA-5244542)
Me2aR4-HIST2H2AC [nucleoplasm]
(R-HSA-5244589)
HIST2H2AC [nucleoplasm]
(R-HSA-181892)
AcK-HIST2H2AC [nucleoplasm]
(R-HSA-4551338)
HIST2H2AC [extracellular region]
(R-HSA-977563)
MeR12-HIST2H2AC [nucleoplasm]
(R-HSA-5229227)
Me2aR12-HIST2H2AC [nucleoplasm]
(R-HSA-5229306)
Me2sR4-HIST2H2AC [nucleoplasm]
(R-HSA-5218305)
MeR4-HIST2H2AC [nucleoplasm]
(R-HSA-5244625)
0.527
3
UniProt:Q9UPY3 DICER1
1
DICER1 [cytosol]
(R-HSA-203820)
0.527
2
UniProt:Q8IX01 SUGP2
0.527
2
UniProt:Q14692 BMS1
1
BMS1 [nucleoplasm]
(R-HSA-6790720)
0.527
2
UniProt:P61313 RPL15
1
RPL15 [cytosol]
(R-HSA-72416)
0.527
3
UniProt:Q9Y4C8 RBM19
0.527
3
UniProt:Q14690 PDCD11
1
PDCD11 [nucleoplasm]
(R-HSA-6790646)
0.527
2
UniProt:Q2Q1W2 TRIM71
1
TRIM71 [cytosol]
(R-HSA-5688972)
0.527
2
UniProt:Q6ZN17 LN28B
0.527
3
UniProt:Q9BRJ6 CG050
0.527
2
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.527
2
UniProt:P60866 RPS20
2
RPS20 [nucleoplasm]
(R-HSA-6798727)
RPS20 [cytosol]
(R-HSA-72349)
0.527
2
UniProt:Q14684 RRP1B
0.527
2
UniProt:Q9NUD5 ZCHC3
0.527
3
UniProt:Q5JTH9 RRP12
0.527
2
UniProt:Q9Y3B9 RRP15
0.527
2
UniProt:P62750 RPL23A
1
RPL23A [cytosol]
(R-HSA-72432)
0.527
2
UniProt:Q6P158 DHX57
0.527
3
UniProt:P42766 RPL35
1
RPL35 [cytosol]
(R-HSA-72460)
0.527
3
UniProt:Q9H6S0 YTDC2
0.527
2
UniProt:Q15397 PUM3
0.527
2
UniProt:Q02878 RPL6
1
RPL6 [cytosol]
(R-HSA-72484)
0.527
3
UniProt:O76094 SRP72
1
SRP72 [cytosol]
(R-HSA-265069)
0.527
3
UniProt:Q9Y3B7 MRPL11
1
MRPL11 [mitochondrial inner membrane]
(R-HSA-5368251)
0.527
2
UniProt:O75569 PRKRA
2
p-S246,S287-PRKRA [cytosol]
(R-HSA-9834791)
PRKRA [cytosol]
(R-HSA-2399897)
0.527
2
UniProt:O95793 STAU1
0.527
3
UniProt:Q00577 PURA
0.527
2
UniProt:Q9NVP1 DDX18
0.527
2
UniProt:Q9NW13 RBM28
1
RBM28 [nucleoplasm]
(R-HSA-6791192)
0.527
2
UniProt:Q8TDN6 BRX1
0.527
2
UniProt:P32969 RPL9
1
RPL9 [cytosol]
(R-HSA-72492)
0.527
2
UniProt:Q96KR1 ZFR
0.527
3
UniProt:Q49A26 GLYR1
0.527
3
UniProt:P49711 CTCF
1
CTCF [nucleoplasm]
(R-HSA-3782562)
0.527
2
UniProt:Q96ME7 ZN512
0.527
2
UniProt:Q96QR8 PURB
0.527
3
UniProt:O75494 SRSF10
1
SRSF10 [nucleoplasm]
(R-HSA-8866646)
0.527
2
UniProt:P36578 RPL4
1
RPL4 [cytosol]
(R-HSA-72474)
0.527
2
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.527
3
UniProt:P18621 RPL17
1
RPL17 [cytosol]
(R-HSA-72418)
0.527
3
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.527
4
UniProt:O75934 BCAS2
1
BCAS2 [nucleoplasm]
(R-HSA-5420902)
0.527
2
UniProt:O15226 NKRF
0.527
2
UniProt:P05387 RPLP2
1
RPLP2 [cytosol]
(R-HSA-72400)
0.527
2
UniProt:P05388 RPLP0
1
RPLP0 [cytosol]
(R-HSA-72396)
0.527
2
UniProt:P62906 RPL10A
1
RPL10A [cytosol]
(R-HSA-72404)
0.527
2
UniProt:Q9NUL3 STAU2
0.527
2
UniProt:Q9NUL7 DDX28
0.527
2
UniProt:P62854 RPS26
2
RPS26 [nucleoplasm]
(R-HSA-6798708)
RPS26 [cytosol]
(R-HSA-72359)
0.527
2
UniProt:P0C0S8 H2AC11
11
K63polyUb-HIST1H2AG [nucleoplasm]
(R-HSA-6783237)
Ub-HIST1H2AG [nucleoplasm]
(R-HSA-6782508)
Ack6-HIST1H2AG [nucleoplasm]
(R-HSA-4568595)
Me2aR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244582)
MeR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244560)
Me2aR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244587)
MeR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244623)
Me2aR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229305)
MeR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229206)
HIST1H2AG [nucleoplasm]
(R-HSA-212084)
Ack-HIST1H2AG [nucleoplasm]
(R-HSA-4551311)
0.527
2
UniProt:Q8TDD1 DDX54
0.527
2
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.527
2
UniProt:P08708 RPS17
2
RPS17 [nucleoplasm]
(R-HSA-6798719)
RPS17 [cytosol]
(R-HSA-72339)
0.527
3
UniProt:Q9HD33 MRPL47
1
MRPL47 [mitochondrial inner membrane]
(R-HSA-5368180)
0.527
3
UniProt:Q9GZR7 DDX24
0.527
3
UniProt:Q9BVI4 NOC4L
1
NOC4L [nucleoplasm]
(R-HSA-6790616)
0.527
3
UniProt:Q9BYG3 MK67I
0.527
2
UniProt:P47914 RPL29
1
RPL29 [cytosol]
(R-HSA-72446)
0.527
2
UniProt:Q9UNQ2 DIMT1
1
DIMT1 [nucleoplasm]
(R-HSA-6791001)
0.527
2
UniProt:Q9BYD3 MRPL4
1
MRPL4 [mitochondrial inner membrane]
(R-HSA-5368212)
0.527
3
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.527
2
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
2
UniProt:Q92665 MRPS31
1
MRPS31 [mitochondrial inner membrane]
(R-HSA-5368198)
0.527
2
UniProt:P62841 RPS15
2
RPS15 [nucleoplasm]
(R-HSA-6798706)
RPS15 [cytosol]
(R-HSA-72335)
0.527
3
UniProt:P82930 MRPS34
1
MRPS34 [mitochondrial inner membrane]
(R-HSA-5368186)
0.527
2
UniProt:Q7L2E3 DHX30
0.527
2
UniProt:Q99575 POP1
1
POP1 [nucleoplasm]
(R-HSA-5696802)
0.527
2
UniProt:P19338 NCL
3
NCL [plasma membrane]
(R-HSA-9836466)
NCL [macropinosome membrane]
(R-HSA-9837666)
NCL [nucleoplasm]
(R-HSA-6791213)
0.527
2
UniProt:Q9NUQ6 SPS2L
0.527
2
UniProt:P16989 YBOX3
0.527
2
UniProt:Q9BQ39 DDX50
0.527
2
UniProt:Q96EY7 PTCD3
1
PTCD3 [mitochondrial inner membrane]
(R-HSA-5368165)
0.527
2
UniProt:Q9H0A0 NAT10
1
NAT10 [nucleoplasm]
(R-HSA-6791008)
0.527
2
UniProt:Q9P015 MRPL15
1
MRPL15 [mitochondrial inner membrane]
(R-HSA-5368193)
0.527
3
UniProt:Q13310 PABP4
0.527
3
UniProt:P62847 RPS24
2
RPS24 [nucleoplasm]
(R-HSA-6791186)
RPS24 [cytosol]
(R-HSA-72355)
0.527
2
UniProt:P82933 MRPS9
1
MRPS9 [mitochondrial inner membrane]
(R-HSA-5368194)
0.527
2
UniProt:Q13435 SF3B2
1
SF3B2 [nucleoplasm]
(R-HSA-71971)
0.527
3
UniProt:Q8IWX8 CHERP
1
CHERP [nucleoplasm]
(R-HSA-8865901)
0.527
3
UniProt:Q9NZB2 F120A
0.527
2
UniProt:Q92552 MRPS27
1
MRPS27 [mitochondrial inner membrane]
(R-HSA-5368214)
0.527
2
UniProt:P62277 RPS13
2
RPS13 [nucleoplasm]
(R-HSA-6791198)
RPS13 [cytosol]
(R-HSA-72331)
0.527
3
UniProt:Q9NY93 DDX56
0.527
2
UniProt:Q9NV31 IMP3
1
IMP3 [nucleoplasm]
(R-HSA-6790664)
0.527
2
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
2
UniProt:O15042 U2SURP
1
U2SURP [nucleoplasm]
(R-HSA-8865950)
0.527
3
UniProt:Q13206 DDX10
0.527
2
UniProt:P51398 DAP3
1
DAP3 [mitochondrial inner membrane]
(R-HSA-5368174)
0.527
2
UniProt:Q71RC2 LARP4
0.527
2
UniProt:Q13601 KRR1
1
KRR1 [nucleoplasm]
(R-HSA-6790611)
0.527
3
UniProt:P61247 RPS3A
2
RPS3A [nucleoplasm]
(R-HSA-6791182)
RPS3A [cytosol]
(R-HSA-72373)
0.527
2
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.527
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.527
3
UniProt:P62917 RPL8
3
3OHH216-RPL8 [nucleoplasm]
(R-HSA-9630976)
RPL8 [nucleoplasm]
(R-HSA-9630985)
RPL8 [cytosol]
(R-HSA-72490)
0.527
2
UniProt:Q13243 SRSF5
1
SRSF5 [nucleoplasm]
(R-HSA-72028)
0.527
2
UniProt:Q96GA3 LTV1
2
LTV1 [nucleoplasm]
(R-HSA-6791566)
LTV1 [cytosol]
(R-HSA-6791520)
0.527
2
UniProt:Q8IY81 FTSJ3
1
FTSJ3 [nucleoplasm]
(R-HSA-6791507)
0.527
3
UniProt:P15880 RPS2
3
RPS2 [nucleoplasm]
(R-HSA-6790655)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [cytosol]
(R-HSA-72347)
0.527
3
UniProt:P05455 SSB
1
SSB [nucleoplasm]
(R-HSA-58418)
0.527
3
IntAct:EBI-2462028 PRE-LET-7A
0.525
3
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.504
4
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.462
3
UniProt:Q9Y3I0 RTCB
1
RTCB [nucleoplasm]
(R-HSA-5696792)
0.462
3
UniProt:Q15393 SF3B3
1
SF3B3 [nucleoplasm]
(R-HSA-71973)
0.462
3
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