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CTPS2 [cytosol]
Stable Identifier
R-HSA-504053
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CTP synthase 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
CTPS2 tetramer [cytosol] (Homo sapiens)
CTPS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRF8 CTPS2
Gene Names
CTPS2
Chain
chain:1-586
Reference Genes
BioGPS Gene:56474 CTPS2
COSMIC (genes):CTPS2 CTPS2
CTD Gene:56474 CTPS2
dbSNP Gene:56474 CTPS2
ENSEMBL:ENSG00000047230 CTPS2
ENSEMBL:ENSG00000047230.15 CTPS2
HGNC:2520 CTPS2
KEGG Gene (Homo sapiens):56474 CTPS2
Monarch:56474 CTPS2
NCBI Gene:56474 CTPS2
OMIM:300380 CTPS2
UCSC:Q9NRF8 CTPS2
Reference Transcript
RefSeq:XM_005274562.3 CTPS2
RefSeq:NM_175859.2 CTPS2
RefSeq:NM_019857.4 CTPS2
RefSeq:NM_001144002.1 CTPS2
RefSeq:XM_006724503.3 CTPS2
Other Identifiers
11732360_a_at
11732361_a_at
17109367
219080_PM_s_at
219080_s_at
222819_PM_at
222819_at
4000851
4000852
4000853
4000854
4000855
4000856
4000857
4000858
4000873
4000874
4000877
4000879
4000885
4000890
4000891
4000893
4000894
4000895
4000896
4000898
4000899
4000901
4000903
4000904
4000905
4000906
4000907
4000908
4000912
4000913
4000914
4000915
45362_g_at
56474
62475_at
64894_at
8171493
A_23_P10305
A_33_P3272593
GE62830
GO:0000166
GO:0003824
GO:0003883
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006220
GO:0006221
GO:0006241
GO:0006520
GO:0006541
GO:0016874
GO:0019856
GO:0042802
GO:0044210
GO:0055086
GO:0097268
GO:1901135
HMNXSV003042598
HMNXSV003047932
Hs.58553.0.S2_3p_at
ILMN_1690693
ILMN_2286024
ILMN_2392352
ILMN_2392356
PH_hs_0024971
TC0X000885.hg
g9789918_3p_s_at
Participates
as a component of
CTPS2 tetramer [cytosol] (Homo sapiens)
Inferred To
CTPS2 [cytosol]
(Bos taurus)
CTPS2 [cytosol]
(Canis familiaris)
CTPS2 [cytosol]
(Danio rerio)
CTPS2 [cytosol]
(Gallus gallus)
CTPS2 [cytosol]
(Plasmodium falciparum)
CTPS2 [cytosol]
(Sus scrofa)
Ctps2 [cytosol]
(Mus musculus)
Ctps2 [cytosol]
(Rattus norvegicus)
Homologues of CTPS2 [cytosol]
(Danio rerio)
Homologues of CTPS2 [cytosol]
(Saccharomyces cerevisiae)
ctps-1 [cytosol]
(Caenorhabditis elegans)
URA8 [cytosol]
(Saccharomyces cerevisiae)
ctps2 [cytosol]
(Xenopus tropicalis)
ura7 [cytosol]
(Schizosaccharomyces pombe)
URA7 [cytosol]
(Saccharomyces cerevisiae)
ctps [cytosol]
(Dictyostelium discoideum)
ctps1 [cytosol]
(Danio rerio)
CTPsyn [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_787055.1
,
XP_006724566.1
,
NP_062831.3
,
XP_005274619.1
,
NP_001137474.1
Guide to Pharmacology - Targets
3216
OpenTargets
ENSG00000047230
GeneCards
Q9NRF8
HPA
ENSG00000047230-CTPS2
Ensembl
ENSP00000369590
,
ENST00000359276
,
ENSP00000352222
,
ENSG00000047230
,
ENST00000443824
,
ENST00000380241
,
ENSP00000401264
PRO
Q9NRF8
Pharos - Targets
Q9NRF8
HMDB Protein
HMDBP04074
PDB
2V4U
,
2VKT
,
7MIH
,
7MH1
,
3IHL
,
7MII
,
6PK7
,
6PK4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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