Reactome | CTPS2 [cytosol]

CTPS2 [cytosol]

Stable Identifier

R-HSA-504053

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CTP synthase 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NRF8 CTPS2

Gene Names

CTPS2

Chain

chain:1-586

Reference Genes

BioGPS Gene:56474 CTPS2

COSMIC (genes):CTPS2 CTPS2

CTD Gene:56474 CTPS2

dbSNP Gene:56474 CTPS2

ENSEMBL:ENSG00000047230 CTPS2

ENSEMBL:ENSG00000047230.15 CTPS2

HGNC:2520 CTPS2

KEGG Gene (Homo sapiens):56474 CTPS2

Monarch:56474 CTPS2

NCBI Gene:56474 CTPS2

OMIM:300380 CTPS2

UCSC:Q9NRF8 CTPS2

Reference Transcript

Other Identifiers

11732360_a_at

11732361_a_at

17109367

219080_PM_s_at

219080_s_at

222819_PM_at

222819_at

4000851

4000852

4000853

4000854

4000855

4000856

4000857

4000858

4000873

4000874

4000877

4000879

4000885

4000890

4000891

4000893

4000894

4000895

4000896

4000898

4000899

4000901

4000903

4000904

4000905

4000906

4000907

4000908

4000912

4000913

4000914

4000915

45362_g_at

56474

62475_at

64894_at

8171493

A_23_P10305

A_33_P3272593

GE62830

GO:0000166

GO:0003824

GO:0003883

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006220

GO:0006221

GO:0006241

GO:0006520

GO:0006541

GO:0016874

GO:0019856

GO:0042802

GO:0044210

GO:0055086

GO:0097268

GO:1901135

HMNXSV003042598

HMNXSV003047932

Hs.58553.0.S2_3p_at

ILMN_1690693

ILMN_2286024

ILMN_2392352

ILMN_2392356

PH_hs_0024971

TC0X000885.hg

g9789918_3p_s_at

Participates

as a component of

CTPS2 tetramer [cytosol] (Homo sapiens)

Inferred To

CTPS2 [cytosol] (Bos taurus)

CTPS2 [cytosol] (Canis familiaris)

CTPS2 [cytosol] (Danio rerio)

CTPS2 [cytosol] (Gallus gallus)

CTPS2 [cytosol] (Plasmodium falciparum)

CTPS2 [cytosol] (Sus scrofa)

Ctps2 [cytosol] (Mus musculus)

Ctps2 [cytosol] (Rattus norvegicus)

Homologues of CTPS2 [cytosol] (Danio rerio)

Homologues of CTPS2 [cytosol] (Saccharomyces cerevisiae)

ctps-1 [cytosol] (Caenorhabditis elegans)

URA8 [cytosol] (Saccharomyces cerevisiae)

ctps2 [cytosol] (Xenopus tropicalis)

ura7 [cytosol] (Schizosaccharomyces pombe)

URA7 [cytosol] (Saccharomyces cerevisiae)

ctps [cytosol] (Dictyostelium discoideum)

ctps1 [cytosol] (Danio rerio)

CTPsyn [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_787055.1, XP_006724566.1, NP_062831.3, XP_005274619.1, NP_001137474.1

Guide to Pharmacology - Targets

3216

OpenTargets

ENSG00000047230

GeneCards

Q9NRF8

HPA

ENSG00000047230-CTPS2

Ensembl

ENSP00000369590, ENST00000359276, ENSP00000352222, ENSG00000047230, ENST00000443824, ENST00000380241, ENSP00000401264

PRO

Q9NRF8

Pharos - Targets

Q9NRF8

HMDB Protein

HMDBP04074

PDB

2V4U, 2VKT, 7MIH, 7MH1, 3IHL, 7MII, 6PK7, 6PK4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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