Reactome | UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

Stable Identifier

R-HSA-504054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

ReviewStatus

5/5

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UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

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Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References

PubMed ID	Title	Journal	Year
10899599	Identification of a cDNA encoding an isoform of human CTP synthetase van Gennip, AH, Vreken, P, van Kuilenberg, AB, Waterham, HR, Meinsma, R	Biochim Biophys Acta	2000
16179339	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS	J Biol Chem	2005