Reactome | BCL2 [mitochondrial outer membrane]

BCL2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-50757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Bcl-2 protein

Locations in the PathwayBrowser for interactor UniProt:P51572 BCAP31

Expand all

External Reference Information

External Reference

UniProt:P10415 BCL2

Gene Names

BCL2

Chain

chain:1-239

Reference Genes

BioGPS Gene:596 BCL2

COSMIC (genes):BCL2 BCL2

CTD Gene:596 BCL2

dbSNP Gene:596 BCL2

ENSEMBL:ENSG00000171791 BCL2

ENSEMBL_homo_sapiens_GENE:ENSG00000171791.14 BCL2

HGNC:990 BCL2

KEGG Gene (Homo sapiens):596 BCL2

Monarch:596 BCL2

NCBI Gene:596 BCL2

UCSC:P10415 BCL2

Reference Transcript

Other Identifiers

11721374_a_at

11721375_a_at

11721376_at

11721377_x_at

11738350_a_at

11738351_x_at

16855673

1847_s_at

1909_at

1910_s_at

203684_PM_s_at

203684_s_at

203685_PM_at

203685_at

2038_g_at

207005_PM_s_at

207005_s_at

244035_PM_at

244035_at

3811353

3811354

3811355

3811356

3811357

3811358

3811359

3811360

3811361

3811362

3811363

3811364

3811432

3811433

3811434

3811435

3811436

3811437

3811438

3811439

3811440

3811441

3811442

3811443

3811444

3811445

3811446

3811447

3811448

3811449

3811450

596

60568_at

8023646

A_23_P208132

A_23_P352266

A_33_P3355185

GE57834

GE848299

GO:0000082

GO:0000209

GO:0000278

GO:0000902

GO:0001503

GO:0001541

GO:0001656

GO:0001657

GO:0001658

GO:0001662

GO:0001776

GO:0001782

GO:0001783

GO:0001822

GO:0001836

GO:0001952

GO:0002020

GO:0002260

GO:0002320

GO:0002326

GO:0002360

GO:0002376

GO:0002520

GO:0002903

GO:0002931

GO:0003014

GO:0003677

GO:0005215

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005741

GO:0005783

GO:0005789

GO:0005829

GO:0006582

GO:0006808

GO:0006874

GO:0006914

GO:0006915

GO:0006950

GO:0006959

GO:0006974

GO:0006979

GO:0007005

GO:0007010

GO:0007015

GO:0007155

GO:0007409

GO:0007565

GO:0008283

GO:0008284

GO:0008285

GO:0008584

GO:0008625

GO:0008630

GO:0008631

GO:0008637

GO:0009314

GO:0009410

GO:0009636

GO:0009791

GO:0009887

GO:0010039

GO:0010224

GO:0010332

GO:0010468

GO:0010506

GO:0010507

GO:0010523

GO:0010559

GO:0012501

GO:0014031

GO:0014042

GO:0014909

GO:0014911

GO:0015267

GO:0016020

GO:0016248

GO:0016477

GO:0019903

GO:0021747

GO:0022414

GO:0022612

GO:0022898

GO:0023052

GO:0030097

GO:0030154

GO:0030183

GO:0030217

GO:0030279

GO:0030307

GO:0030308

GO:0030318

GO:0030336

GO:0030890

GO:0031069

GO:0031103

GO:0031625

GO:0031647

GO:0031965

GO:0031966

GO:0032469

GO:0032835

GO:0032848

GO:0032880

GO:0032991

GO:0033028

GO:0033033

GO:0033077

GO:0033138

GO:0033687

GO:0033689

GO:0034097

GO:0034330

GO:0035094

GO:0035265

GO:0036211

GO:0040008

GO:0040018

GO:0042100

GO:0042149

GO:0042542

GO:0042551

GO:0042802

GO:0042803

GO:0042981

GO:0043029

GO:0043065

GO:0043066

GO:0043067

GO:0043209

GO:0043226

GO:0043375

GO:0043473

GO:0043524

GO:0043565

GO:0043583

GO:0045069

GO:0045636

GO:0045930

GO:0046666

GO:0046671

GO:0046902

GO:0046930

GO:0046982

GO:0048041

GO:0048066

GO:0048070

GO:0048087

GO:0048536

GO:0048538

GO:0048545

GO:0048546

GO:0048589

GO:0048599

GO:0048741

GO:0048743

GO:0048753

GO:0048856

GO:0048864

GO:0048870

GO:0048873

GO:0050853

GO:0051384

GO:0051402

GO:0051434

GO:0051607

GO:0051649

GO:0051721

GO:0051726

GO:0051881

GO:0051902

GO:0051924

GO:0055065

GO:0055085

GO:0060090

GO:0060218

GO:0060402

GO:0061024

GO:0070059

GO:0070227

GO:0070229

GO:0070231

GO:0070233

GO:0071310

GO:0071456

GO:0072593

GO:0097048

GO:0097049

GO:0097136

GO:0097138

GO:0097192

GO:0098542

GO:0098609

GO:0098772

GO:0140297

GO:1901135

GO:1902166

GO:1904019

GO:1904036

GO:2000134

GO:2000378

GO:2000669

GO:2000672

GO:2000811

GO:2001233

GO:2001234

GO:2001240

GO:2001243

HMNXSV003005180

HMNXSV003028393

Hs.46996.0.A1_3p_at

ILMN_1701120

ILMN_1801119

ILMN_2246956

ILMN_2363250

M13994_s_at

M14745_at

PH_hs_0004581

TC18000554.hg

TC18000952.hg

g179366_3p_a_at

g4557354_3p_at

g4557356_3p_a_at

g4557356_3p_x_at

p7786

Participates

as an output of

as a component of

as an input of

as a member of

Bcl-2/Bcl-X(L) [mitochondrial outer membrane] (Homo sapiens)

Inferred To

bcl2a [mitochondrial outer membrane] (Danio rerio)

BCL2 [mitochondrial outer membrane] (Bos taurus)

BCL2 [mitochondrial outer membrane] (Canis familiaris)

BCL2 [mitochondrial outer membrane] (Gallus gallus)

BCL2 [mitochondrial outer membrane] (Sus scrofa)

Bcl2 [mitochondrial outer membrane] (Mus musculus)

bcl2 [mitochondrial outer membrane] (Xenopus tropicalis)

ced-9 [mitochondrial outer membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000648.2, NP_000624.2

Guide to Pharmacology - Targets

2844

OpenTargets

ENSG00000171791

ZINC - Substances

BCL2_HUMAN

ZINC - Biogenic

BCL2_HUMAN

ZINC target

P10415

PRO

P10415

PDB

8HOI, 2W3L, 5VAY, 8HLL, 8IQL, 4LXD, 8U27, 8HLM, 6GL8, 8HLN, 4MAN, 4LVT, 2O22, 1GJH, 1YSW, 6O0K, 2O21, 6O0L, 2XA0, 1G5M, 6O0M, 7YA5, 8FY1, 7Y90, 5VAU, 4IEH, 5AGW, 6O0O, 8FY2, 6IWB, 8HOG, 2O2F, 6O0P, 5VAX, 7LHB, 5FCG, 5AGX, 5JSN, 4AQ3, 8HOH

ZINC - Investigational

BCL2_HUMAN

ZINC - Metabolites

BCL2_HUMAN

HPA

ENSG00000171791-BCL2

GeneCards

P10415

Ensembl

ENSP00000466417, ENSP00000504190, ENSP00000329623, ENST00000589955, ENSG00000171791, ENST00000678349, ENSP00000381185, ENST00000398117, ENST00000333681

Pharos - Targets

P10415

ZINC - Predictions - Purchasable

BCL2_HUMAN

Orphanet

15362

HMDB Protein

HMDBP02442

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.951	18
UniProt:Q07812 BAX	3	BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907) BAX [mitochondrial outer membrane] (R-HSA-139949)	0.948	16
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.926	11
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.869	9
UniProt:Q13323 BIK			0.861	7
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.851	7
UniProt:Q9BXH1 BBC3	2	BBC3 [cytosol] (R-HSA-140220) BBC3 [mitochondrial outer membrane] (R-HSA-140222)	0.815	6
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.746	13
UniProt:Q61337 Bad	6	phospho-Bad [cytosol] (R-MMU-217297) Bad [mitochondrial outer membrane] (R-MMU-114242) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) Bad [cytosol] (R-MMU-50662) phospho-Bad [cytosol] (R-MMU-198335)	0.722	6
UniProt:O43521-2 BCL2L11			0.713	4
UniProt:O43521-1 BCL2L11			0.702	3
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.674	7
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.659	10
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.655	10
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.632	4
UniProt:Q91ZE9	3	phospho-Bmf [mitochondrial outer membrane] (R-MMU-3145026) phospho-Bmf [cytosol] (R-MMU-140529) Bmf [plasma membrane] (R-MMU-140209)	0.623	2
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.609	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.589	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	5
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8N5K1 CISD2			0.544	2
UniProt:P11881	2	ITPR1 [platelet dense tubular network membrane] (R-MMU-3325593) ITPR1 [endoplasmic reticulum membrane] (R-MMU-3006433)	0.524	3
UniProt:Q13794 PMAIP1	2	PMAIP1 [mitochondrial outer membrane] (R-HSA-140218) PMAIP1 [cytosol] (R-HSA-140215)	0.524	3
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.524	2
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.499	4
UniProt:Q9NYF8 BCLF1			0.499	2
UniProt:P63098 PPP3R1	2	PPP3R1 [nucleoplasm] (R-HSA-2685631) PPP3R1 [cytosol] (R-HSA-51291)	0.489	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.488	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.488	2
UniProt:Q9H2V7 SPNS1			0.463	2

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