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BCL2L1 [cytosol]
Stable Identifier
R-HSA-50771
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Apoptosis regulator Bcl-X, Bcl-2-like 1 protein
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating tumorigenic genes (Homo sapiens)
NFE2L2 dependent BCL2L1 expression (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1-mediated effects on programmed cell death (Homo sapiens)
SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)
7a:BLC2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
SARS-CoV-1 E binds BCL2L1 (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
E:BCL2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
BCL2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07817 BCL2L1
Gene Names
BCL2L1, BCL2L, BCLX
Chain
chain:1-233
Reference Genes
BioGPS Gene:598 BCL2L1
COSMIC (genes):BCL2L1 BCL2L1
CTD Gene:598 BCL2L1
dbSNP Gene:598 BCL2L1
ENSEMBL:ENSG00000171552 BCL2L1
HGNC:992 BCL2L1
KEGG:hsa:598 BCL2L1
Monarch:598 BCL2L1
NCBI Gene:598 BCL2L1
OMIM:600039 BCL2L1
UCSC:Q07817 BCL2L1
Reference Transcript
RefSeq:NM_001322240.2 BCL2L1
RefSeq:XM_017027993.1 BCL2L1
RefSeq:XM_011528964.2 BCL2L1
RefSeq:NM_001424332.1 BCL2L1
RefSeq:NM_001317921.2 BCL2L1
RefSeq:NM_001322239.2 BCL2L1
RefSeq:NM_001322242.2 BCL2L1
RefSeq:NM_001317919.2 BCL2L1
RefSeq:NM_001191.4 BCL2L1
RefSeq:NM_001317920.2 BCL2L1
RefSeq:NM_001424331.1 BCL2L1
RefSeq:NM_138578.3 BCL2L1
Participates
as an output of
FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)
NFE2L2 dependent BCL2L1 expression (Homo sapiens)
as a component of
E:BCL2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
7a:BLC2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
as an input of
SARS-CoV-1 E binds BCL2L1 (Homo sapiens)
SARS-CoV-1 7a binds BCL2L1 (Homo sapiens)
Other forms of this molecule
BCL2L1 [mitochondrial outer membrane]
Cross References
RefSeq
NP_001309169.1
,
XP_016883482.1
,
NP_612815.1
,
NP_001304848.1
,
NP_001304850.1
,
NP_001411260.1
,
NP_001411261.1
,
NP_001182.1
,
NP_001304849.1
,
NP_001309168.1
,
NP_001309171.1
,
XP_011527266.1
Guide to Pharmacology - Targets
2845
OpenTargets
ENSG00000171552
ENSEMBL
ENST00000677194
,
ENST00000678563
,
ENST00000422920
,
ENST00000434194
,
ENSP00000389688
,
ENSP00000504237
,
ENST00000676582
,
ENSP00000395545
,
ENST00000376062
,
ENSP00000504536
,
ENSP00000365230
,
ENST00000439267
,
ENSP00000401173
,
ENSP00000503725
,
ENSP00000411252
,
ENST00000456404
,
ENSP00000504387
,
ENSG00000171552
,
ENST00000307677
,
ENSP00000365223
,
ENST00000376055
,
ENST00000676942
,
ENSP00000302564
,
ENST00000420488
,
ENSP00000390760
ZINC - Substances
B2CL1_HUMAN
ZINC - Biogenic
B2CL1_HUMAN
ZINC target
Q07817
PRO
Q07817
PDB
2P1L
,
6UVF
,
1R2E
,
6F46
,
7XGG
,
7YAA
,
6O0L
,
4AQ3
,
3QKD
,
8U27
,
3INQ
,
2YQ6
,
6O0M
,
7Y8D
,
1BXL
,
2YXJ
,
3FDM
,
2O1Y
,
1YSG
,
3SP7
,
6ST2
,
5FMJ
,
6UVG
,
3ZK6
,
4HNJ
,
3CVA
,
2B48
,
4BPK
,
3ZLN
,
6UVE
,
6YLI
,
9AQZ
,
3PL7
,
6O0O
,
4EHR
,
5VAY
,
7LH7
,
3WIZ
,
8VWZ
,
2ME8
,
5VX3
,
4TUH
,
4A1U
,
3IO8
,
8XP5
,
4PPI
,
8IQL
,
3FDL
,
1YSI
,
6ZHC
,
4C52
,
6UVD
,
6BF2
,
2O2N
,
7CA4
,
2LPC
,
2O2M
,
8VWX
,
4QVX
,
6RNU
,
4Z9V
,
1YSN
,
3ZLO
,
1R2H
,
6X7I
,
2YQ7
,
7JGW
,
6O0K
,
6IJQ
,
6DCO
,
6DCN
,
2ME9
,
5AGX
,
8WLS
,
3R85
,
2M04
,
6HJL
,
2M03
,
4CIN
,
2LP8
,
4QVE
,
1MAZ
,
1LXL
,
3SPF
,
4C5D
,
2YJ1
,
1R2D
,
1R2G
,
3ZLR
,
7XGF
,
1R2I
,
7JGV
,
6VWC
,
8FY0
,
6O0P
,
2PON
,
5C3G
,
5B1Z
,
5AGW
,
8VXM
,
4A1W
,
8IQK
,
4QVF
,
8VXN
,
4IEH
,
2MEJ
,
1G5J
,
6UVC
,
5FMK
,
6UVH
,
6LHD
ZINC - Investigational
B2CL1_HUMAN
ZINC - Metabolites
B2CL1_HUMAN
GeneCards
BCL2L1
HPA
ENSG00000171552-BCL2L1
Pharos - Targets
Q07817
ZINC - Predictions - Purchasable
B2CL1_HUMAN
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.978
51
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.961
39
UniProt:Q13323 BIK
0.914
12
UniProt:O43521 BCL2L11
7
BCL2L11 [cytosol]
(R-HSA-2976673)
p-BCL2L11 [cytosol]
(R-HSA-140525)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
0.866
12
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.805
12
UniProt:P55957 BID
4
MYS-BID(62-195) [mitochondrial outer membrane]
(R-HSA-114266)
MYS-BID(62-195) [cytosol]
(R-HSA-141373)
BID(1-195) [cytosol]
(R-HSA-50825)
BID(62-195) [cytosol]
(R-HSA-139953)
0.749
4
UniProt:Q07812 BAX
3
BAX [mitochondrial outer membrane]
(R-HSA-139949)
BAX activated [cytosol]
(R-HSA-139907)
BAX [cytosol]
(R-HSA-139916)
0.706
6
UniProt:Q9C000 NLRP1
1
NLRP1 [cytosol]
(R-HSA-561196)
0.646
9
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.596
7
UniProt:Q9BXH1 BBC3
2
BBC3 [cytosol]
(R-HSA-140220)
BBC3 [mitochondrial outer membrane]
(R-HSA-140222)
0.59
2
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.564
2
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:P22749 GNLY
2
GNLY [phagocytic vesicle lumen]
(R-HSA-6807564)
GNLY [extracellular region]
(R-HSA-6806691)
0.556
3
UniProt:Q7Z5B4-5 RIC3
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:P27469 G0S2
1
G0S2 [lipid droplet]
(R-HSA-1989741)
0.556
3
UniProt:Q5T7V8 GORAB
0.556
3
UniProt:Q8IYJ2-2 C10ORF67
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.556
3
UniProt:P56557 TM50B
0.556
3
UniProt:P0C671 BNIP5
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:P49810 PSEN2
2
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
0.543
3
UniProt:Q86SR1 GALNT10
1
GALNT10 [Golgi membrane]
(R-HSA-913664)
0.527
2
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q9NYS7 WSB2
1
WSB2 [cytosol]
(R-HSA-8863349)
0.527
2
UniProt:Q07817 BCL2L1
2
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
BCL2L1 [cytosol]
(R-HSA-50771)
0.524
2
UniProt:P45983 MAPK8
3
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
MAPK8 [cytosol]
(R-HSA-168141)
0.516
2
UniProt:Q9H2V7 SPNS1
0.463
3
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