Reactome | BCL2L1 [cytosol]

BCL2L1 [cytosol]

Stable Identifier

R-HSA-50771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Apoptosis regulator Bcl-X, Bcl-2-like 1 protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q07817 BCL2L1

Gene Names

BCL2L1, BCL2L, BCLX

Chain

chain:1-233

Reference Genes

BioGPS Gene:598 BCL2L1

COSMIC (genes):BCL2L1 BCL2L1

CTD Gene:598 BCL2L1

dbSNP Gene:598 BCL2L1

ENSEMBL:ENSG00000171552 BCL2L1

HGNC:992 BCL2L1

KEGG Gene (Homo sapiens):598 BCL2L1

Monarch:598 BCL2L1

NCBI Gene:598 BCL2L1

OMIM:600039 BCL2L1

UCSC:Q07817 BCL2L1

Reference Transcript

Other Identifiers

0003060161

0003060273

11739957_a_at

11739958_x_at

11759514_at

1615_at

16918244

206665_s_at

212312_at

215037_s_at

231228_at

34742_at

3902490

3902491

3902492

3902493

3902522

3902523

3902524

3902525

3902526

3902527

3902528

3902529

3902530

598

65477_at

8065569

82590_at

A_23_P210886

A_24_P100130

GE60374

GE60550

GO:0000278

GO:0001836

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006810

GO:0006897

GO:0006914

GO:0006915

GO:0006950

GO:0007005

GO:0007049

GO:0007093

GO:0007165

GO:0008150

GO:0008219

GO:0008630

GO:0008637

GO:0009056

GO:0010507

GO:0016020

GO:0016021

GO:0016192

GO:0019050

GO:0019221

GO:0019899

GO:0019901

GO:0030054

GO:0030672

GO:0031410

GO:0031965

GO:0032465

GO:0032991

GO:0034097

GO:0042802

GO:0042803

GO:0042981

GO:0043066

GO:0043226

GO:0044403

GO:0045202

GO:0046902

GO:0046982

GO:0051301

GO:0051434

GO:0051607

GO:0051881

GO:0061024

GO:0090201

GO:0097136

GO:0097192

GO:1900118

GO:1902042

GO:1902230

GO:1902236

GO:1903077

GO:2000811

GO:2001240

GO:2001243

GO:2001244

HMNXSV003013398

HMNXSV003029432

Hs.143912.0.A1_3p_at

Hs.305890.1.S1_3p_at

Hs.305890.2.S1_3p_a_at

ILMN_1654118

ILMN_1742410

PH_hs_0015713

TC20000756.hg

TC20001531.hg

Z23115_at

g4502380_3p_a_at

Participates

as an output of

FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)

Other forms of this molecule

BCL2L1 [mitochondrial outer membrane]

Cross References

RefSeq

NP_001309169.1, NP_001304849.1, XP_011527266.1, NP_001309171.1, NP_001304850.1, NP_612815.1, XP_016883482.1, NP_001304848.1, NP_001182.1, NP_001309168.1

OpenTargets

ENSG00000171552

ZINC - Substances

B2CL1_HUMAN

ZINC target

Q07817

ZINC - Biogenic

B2CL1_HUMAN

PRO

Q07817

PDB

2B48, 3CVA, 2ME9, 3SP7, 2YQ7, 2LPC, 3ZLN, 3ZLO, 6O0P, 6RNU, 6BF2, 2LP8, 6O0O, 4C5D, 6IJQ, 6DCN, 2YXJ, 6O0M, 2YQ6, 2ME8, 2PON, 6O0L, 6HJL, 5AGX, 4QVF, 3FDL, 4AQ3, 3FDM, 2P1L, 3ZLR, 2YJ1, 6O0K, 5VX3, 6ZHC, 2MEJ, 5AGW, 6ST2, 3SPF, 3IO8, 1BXL, 4QVX, 1YSI, 3ZK6, 5B1Z, 2O1Y, 4IEH, 1YSG, 6DCO, 1R2E, 5FMK, 3PL7, 7CA4, 3INQ, 6X7I, 1G5J, 1YSN, 1R2D, 5C3G, 1R2H, 3WIZ, 5VAY, 2O2M, 4TUH, 4A1U, 2M04, 1R2G, 4PPI, 2O2N, 4CIN, 4BPK, 3QKD, 1LXL, 5FMJ, 4A1W, 6F46, 4QVE, 3R85, 1R2I, 6VWC, 4EHR, 4HNJ, 4C52, 2M03, 4Z9V, 1MAZ

ZINC - Investigational

B2CL1_HUMAN

ZINC - Metabolites

B2CL1_HUMAN

GeneCards

Q07817

HPA

ENSG00000171552-BCL2L1

Ensembl

ENSG00000171552, ENSP00000365230, ENST00000376062, ENSP00000302564, ENSP00000365223, ENST00000376055, ENST00000307677

ZINC - Predictions - Purchasable

B2CL1_HUMAN

Orphanet

25595

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	BAD [cytosol] (R-HSA-50662) p-S99-BAD [cytosol] (R-HSA-198335) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.973	34
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.946	27
UniProt:Q13323 BIK			0.914	12
UniProt:Q96LC9 BMF	3	p-BMF(1-89) [cytosol] (R-HSA-140529) BMF [plasma membrane] (R-HSA-140209) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.805	12
UniProt:O43521 BCL2L11	7	BCL2L11-BRAF fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-BCL2L11-BRAF fusion [cytosol] (R-HSA-6802519) p-S65-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.775	8
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.646	9
UniProt:P55957 BID	4	MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(62-195) [cytosol] (R-HSA-139953) MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) BID(1-195) [cytosol] (R-HSA-50825)	0.571	2
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:Q8NBJ4 GOLM1	2	GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710) p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q9H6H4 REEP4	1	REEP4 [endoplasmic reticulum membrane] (R-HSA-8939764)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.556	3
UniProt:Q7Z5B4-5 RIC3			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P27469 G0S2	1	G0S2 [lipid droplet] (R-HSA-1989741)	0.556	3
UniProt:P22749 GNLY	2	GNLY [extracellular region] (R-HSA-6806691) GNLY [phagocytic vesicle lumen] (R-HSA-6807564)	0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.543	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.524	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.516	2
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.483	3
UniProt:Q9H2V7 SPNS1			0.463	3

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