Reactome | BCL2L1 [cytosol]

BCL2L1 [cytosol]

Stable Identifier

R-HSA-50771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Apoptosis regulator Bcl-X, Bcl-2-like 1 protein

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating tumorigenic genes (Homo sapiens)
        
        NFE2L2 dependent BCL2L1 expression (Homo sapiens)
        
        BCL2L1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07817 BCL2L1

Gene Names

BCL2L1, BCL2L, BCLX

Chain

chain:1-233

Reference Genes

BioGPS Gene:598 BCL2L1

COSMIC (genes):BCL2L1 BCL2L1

CTD Gene:598 BCL2L1

dbSNP Gene:598 BCL2L1

ENSEMBL:ENSG00000171552 BCL2L1

HGNC:992 BCL2L1

KEGG:hsa:598 BCL2L1

Monarch:598 BCL2L1

NCBI Gene:598 BCL2L1

OMIM:600039 BCL2L1

UCSC:Q07817 BCL2L1

Reference Transcript

Participates

as an output of

as a component of

as an input of

Other forms of this molecule

BCL2L1 [mitochondrial outer membrane]

Cross References

RefSeq

NP_001309169.1, XP_016883482.1, NP_612815.1, NP_001304848.1, NP_001304850.1, NP_001411260.1, NP_001411261.1, NP_001182.1, NP_001304849.1, NP_001309168.1, NP_001309171.1, XP_011527266.1

Guide to Pharmacology - Targets

2845

OpenTargets

ENSG00000171552

ENSEMBL

ENST00000677194, ENST00000678563, ENST00000422920, ENST00000434194, ENSP00000389688, ENSP00000504237, ENST00000676582, ENSP00000395545, ENST00000376062, ENSP00000504536, ENSP00000365230, ENST00000439267, ENSP00000401173, ENSP00000503725, ENSP00000411252, ENST00000456404, ENSP00000504387, ENSG00000171552, ENST00000307677, ENSP00000365223, ENST00000376055, ENST00000676942, ENSP00000302564, ENST00000420488, ENSP00000390760

ZINC - Substances

B2CL1_HUMAN

ZINC - Biogenic

B2CL1_HUMAN

ZINC target

Q07817

PRO

Q07817

PDB

2P1L, 6UVF, 1R2E, 6F46, 7XGG, 7YAA, 6O0L, 4AQ3, 3QKD, 8U27, 3INQ, 2YQ6, 6O0M, 7Y8D, 1BXL, 2YXJ, 3FDM, 2O1Y, 1YSG, 3SP7, 6ST2, 5FMJ, 6UVG, 3ZK6, 4HNJ, 3CVA, 2B48, 4BPK, 3ZLN, 6UVE, 6YLI, 9AQZ, 3PL7, 6O0O, 4EHR, 5VAY, 7LH7, 3WIZ, 8VWZ, 2ME8, 5VX3, 4TUH, 4A1U, 3IO8, 8XP5, 4PPI, 8IQL, 3FDL, 1YSI, 6ZHC, 4C52, 6UVD, 6BF2, 2O2N, 7CA4, 2LPC, 2O2M, 8VWX, 4QVX, 6RNU, 4Z9V, 1YSN, 3ZLO, 1R2H, 6X7I, 2YQ7, 7JGW, 6O0K, 6IJQ, 6DCO, 6DCN, 2ME9, 5AGX, 8WLS, 3R85, 2M04, 6HJL, 2M03, 4CIN, 2LP8, 4QVE, 1MAZ, 1LXL, 3SPF, 4C5D, 2YJ1, 1R2D, 1R2G, 3ZLR, 7XGF, 1R2I, 7JGV, 6VWC, 8FY0, 6O0P, 2PON, 5C3G, 5B1Z, 5AGW, 8VXM, 4A1W, 8IQK, 4QVF, 8VXN, 4IEH, 2MEJ, 1G5J, 6UVC, 5FMK, 6UVH, 6LHD

ZINC - Investigational

B2CL1_HUMAN

ZINC - Metabolites

B2CL1_HUMAN

GeneCards

BCL2L1

HPA

ENSG00000171552-BCL2L1

Pharos - Targets

Q07817

ZINC - Predictions - Purchasable

B2CL1_HUMAN

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.978	51
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.961	39
UniProt:Q13323 BIK			0.914	12
UniProt:O43521 BCL2L11	7	BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [cytosol] (R-HSA-140525) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674)	0.866	12
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.805	12
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.749	4
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.706	6
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.646	9
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.596	7
UniProt:Q9BXH1 BBC3	2	BBC3 [cytosol] (R-HSA-140220) BBC3 [mitochondrial outer membrane] (R-HSA-140222)	0.59	2
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.564	2
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P22749 GNLY	2	GNLY [phagocytic vesicle lumen] (R-HSA-6807564) GNLY [extracellular region] (R-HSA-6806691)	0.556	3
UniProt:Q7Z5B4-5 RIC3			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:P27469 G0S2	1	G0S2 [lipid droplet] (R-HSA-1989741)	0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q8IYJ2-2 C10ORF67			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:P56557 TM50B			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.543	3
UniProt:Q86SR1 GALNT10	1	GALNT10 [Golgi membrane] (R-HSA-913664)	0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:Q9NYS7 WSB2	1	WSB2 [cytosol] (R-HSA-8863349)	0.527	2
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.524	2
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141)	0.516	2
UniProt:Q9H2V7 SPNS1			0.463	3

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