Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MAP3K3 [cytosol]
Stable Identifier
R-HSA-507725
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEKK3, Mitogen-activated protein kinase kinase kinase 3, M3K3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
MAP3K3 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
MAP3K3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99759 MAP3K3
Gene Names
MAP3K3, MAPKKK3, MEKK3
Chain
chain:1-626
Reference Genes
BioGPS Gene:4215 MAP3K3
COSMIC (genes):MAP3K3 MAP3K3
CTD Gene:4215 MAP3K3
dbSNP Gene:4215 MAP3K3
ENSEMBL:ENSG00000198909 MAP3K3
ENSEMBL_homo_sapiens_GENE:ENSG00000198909.8 MAP3K3
HGNC:6855 MAP3K3
KEGG Gene (Homo sapiens):4215 MAP3K3
Monarch:4215 MAP3K3
NCBI Gene:4215 MAP3K3
OMIM:602539 MAP3K3
UCSC:Q99759 MAP3K3
Reference Transcript
RefSeq:NM_002401.3 MAP3K3
RefSeq:NM_203351.1 MAP3K3
Other Identifiers
11720218_a_at
11720219_a_at
11737820_a_at
1330_at
16836985
203514_PM_at
203514_at
227131_PM_at
227131_at
3730807
3730808
3730809
3730810
3730811
3730813
3730826
3730828
3730831
3730836
3730846
3730848
3730851
3730853
3730854
3730856
3730857
3730858
3730859
3730860
3730861
3730862
3730863
3730865
4215
43929_at
44635_at
8009183
A_14_P101684
A_14_P122017
A_14_P125072
A_14_P200491
A_23_P207131
A_23_P207138
A_33_P3271430
GE61966
GO:0000165
GO:0000166
GO:0001568
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006468
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0035556
GO:0036211
GO:0043123
GO:0046777
GO:0046872
GO:0048856
GO:0048870
GO:0071864
GO:0090050
GO:0106310
GO:0140096
GO:1900745
GO:2000773
HMNXSV003027613
HMNXSV003034332
Hs.25227.0.A1_3p_at
Hs.29282.0.S2_3p_at
ILMN_1779010
ILMN_2296697
PH_hs_0002542
TC17000770.hg
U78876_at
Participates
as a component of
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
Inferred To
Homologues of MAP3K3 [cytosol]
(Caenorhabditis elegans)
Homologues of MAP3K3 [cytosol]
(Dictyostelium discoideum)
drl-1 [cytosol]
(Caenorhabditis elegans)
mtk-1 [cytosol]
(Caenorhabditis elegans)
MAP3K3 [cytosol]
(Bos taurus)
MAP3K3 [cytosol]
(Canis familiaris)
MAP3K3 [cytosol]
(Dictyostelium discoideum)
MAP3K3 [cytosol]
(Gallus gallus)
MAP3K3 [cytosol]
(Mus musculus)
MAP3K3 [cytosol]
(Rattus norvegicus)
MAP3K3 [cytosol]
(Sus scrofa)
mekk-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_976226.1
,
NP_002392.2
ZINC - World Drugs
M3K3_HUMAN
Guide to Pharmacology - Targets
2078
OpenTargets
ENSG00000198909
ZINC - FDA approved
M3K3_HUMAN
ZINC - Substances
M3K3_HUMAN
ZINC - Biogenic
M3K3_HUMAN
ZINC target
Q99759
PRO
Q99759
PDB
2O2V
,
2C60
,
4YL6
,
4Y5O
,
2JRH
,
2PPH
ZINC - Investigational
M3K3_HUMAN
HPA
ENSG00000198909-MAP3K3
GeneCards
Q99759
Ensembl
ENSP00000354927
,
ENSP00000354485
,
ENST00000361357
,
ENSP00000461988
,
ENST00000361733
,
ENST00000579585
,
ENSG00000198909
Pharos - Targets
Q99759
ZINC - Predictions - Purchasable
M3K3_HUMAN
HMDB Protein
HMDBP01142
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.802
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.802
6
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.744
5
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.731
5
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.564
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.536
2
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.536
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text