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CHRNA7 [plasma membrane]
Stable Identifier
R-HSA-507830
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuronal acetylcholine receptor subunit alpha-7, ACHA7_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Acetylcholine binding and downstream events (Homo sapiens)
Postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [plasma membrane] (Homo sapiens)
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
CHRNA7 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36544 CHRNA7
Gene Names
CHRNA7, NACHRA7
Chain
signal peptide:1-22, chain:23-502
Reference Genes
BioGPS Gene:1139 CHRNA7
BioGPS Gene:89832 CHRNA7
COSMIC (genes):CHRNA7 CHRNA7
CTD Gene:1139 CHRNA7
CTD Gene:89832 CHRNA7
dbSNP Gene:1139 CHRNA7
dbSNP Gene:89832 CHRNA7
ENSEMBL:ENSG00000175344 CHRNA7
ENSEMBL_homo_sapiens_GENE:ENSG00000175344.19 CHRNA7
ENSEMBL_homo_sapiens_GENE:ENSG00000274542.1 CHRNA7
HGNC:1960 CHRNA7
KEGG Gene (Homo sapiens):1139 CHRNA7
Monarch:1139 CHRNA7
Monarch:89832 CHRNA7
NCBI Gene:1139 CHRNA7
NCBI Gene:89832 CHRNA7
OMIM:118511 CHRNA7
UCSC:P36544 CHRNA7
Reference Transcript
RefSeq:NM_148911.1 CHRNA7
RefSeq:NM_001190455.2 CHRNA7
RefSeq:XM_017021884.1 CHRNA7
RefSeq:XM_005254750.2 CHRNA7
RefSeq:NM_000746.5 CHRNA7
Other Identifiers
1139
11739850_s_at
11740008_s_at
11740009_a_at
11750964_s_at
16798765
210123_PM_s_at
210123_s_at
236385_PM_at
236385_at
3587230
3587231
3587232
3587240
3587242
3587250
3587252
3587253
3587254
3587256
3587257
3587259
3587260
3587261
3587262
3587271
3587273
3587274
3615785
3615786
3615788
3615790
3615792
3615793
3615795
3615796
3615798
3615799
3615800
3615802
39566_at
69847_at
7982341
7987012
80966_at
A_23_P163390
A_32_P35969
A_33_P3313519
A_33_P3719083
GE80948
GO:0001540
GO:0001666
GO:0001934
GO:0004888
GO:0005215
GO:0005216
GO:0005230
GO:0005262
GO:0005515
GO:0005886
GO:0005892
GO:0006811
GO:0006816
GO:0006874
GO:0007154
GO:0007165
GO:0007271
GO:0007611
GO:0007613
GO:0007614
GO:0008284
GO:0015464
GO:0015643
GO:0016020
GO:0017081
GO:0022848
GO:0023052
GO:0030154
GO:0032720
GO:0034220
GO:0034330
GO:0035094
GO:0036211
GO:0042166
GO:0042803
GO:0043005
GO:0043410
GO:0044853
GO:0045202
GO:0045211
GO:0045766
GO:0048856
GO:0050808
GO:0050877
GO:0050890
GO:0050893
GO:0051247
GO:0055065
GO:0055085
GO:0060078
GO:0060079
GO:0060089
GO:0070374
GO:0070588
GO:0095500
GO:0097061
GO:0098772
GO:0098794
GO:0098815
GO:0140059
GO:1900273
GO:1902004
GO:1902430
GO:1902991
GO:1904645
GO:1905144
GO:1905906
GO:1905920
GO:2000463
HMNXSV003024178
Hs.207457.0.A1_3p_at
ILMN_1683373
ILMN_1788789
ILMN_1791501
PH_hs_0027395
PH_hs_0040493
TC15002129.hg
TC15002755.hg
X70297_at
g1458119_3p_a_at
p5075
Participates
as a member of
acetylcholine receptor subunits [plasma membrane] (Homo sapiens)
as a component of
Acetylcholine receptor containing alpha7 subunit [plasma membrane] (Homo sapiens)
Inferred To
acr-25 [plasma membrane]
(Caenorhabditis elegans)
nAChRalpha6 [plasma membrane]
(Drosophila melanogaster)
CHRNA7 [plasma membrane]
(Bos taurus)
CHRNA7 [plasma membrane]
(Canis familiaris)
CHRNA7 [plasma membrane]
(Gallus gallus)
CHRNA7 [plasma membrane]
(Sus scrofa)
chrna7a [plasma membrane]
(Danio rerio)
chrna7 [plasma membrane]
(Xenopus tropicalis)
Chrna7 [plasma membrane]
(Mus musculus)
Chrna7 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_683709.1
,
NP_001177384.1
,
NP_000737.1
,
XP_016877373.1
,
XP_005254807.1
ZINC - World Drugs
ACHA7_HUMAN
Guide to Pharmacology - Targets
468
OpenTargets
ENSG00000175344
ZINC - FDA approved
ACHA7_HUMAN
ZINC - Substances
ACHA7_HUMAN
ZINC - Biogenic
ACHA7_HUMAN
ZINC target
P36544
PRO
P36544
PDB
8V82
,
8V80
,
8V8D
,
7KOX
,
8F4V
,
5AFH
,
7EKI
,
8UT1
,
8CE4
,
8V88
,
8CI2
,
8CI1
,
8V86
,
5AFJ
,
8UTB
,
5AFL
,
5AFK
,
7RPM
,
7KOO
,
7EKT
,
2MAW
,
7EKP
,
8V89
,
8P1H
,
7KOQ
,
8UZJ
,
8CAU
,
8C9X
,
8V8A
,
5AFM
,
5AFN
,
8V8C
ZINC - Investigational
ACHA7_HUMAN
ZINC - Metabolites
ACHA7_HUMAN
GeneCards
P36544
HPA
ENSG00000175344-CHRNA7
Ensembl
ENSP00000303727
,
ENSG00000274542
,
ENSP00000407546
,
ENST00000306901
,
ENSP00000399087
,
ENSG00000175344
,
ENST00000437966
,
ENSP00000405989
,
ENST00000675428
,
ENSP00000502560
,
ENST00000454250
,
ENST00000455693
Pharos - Targets
P36544
Orphanet
20105
ZINC - Predictions - Purchasable
ACHA7_HUMAN
HMDB Protein
HMDBP12048
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.646
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.556
3
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