Aquaporins passively transport urea into cells

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-9 (AQP9) and AQP10 are 6-pass transmembrane proteins that passively transport urea across the plasma membrane through a pore in each subunit of a homotetramer.
Literature References
PubMed ID Title Journal Year
12084581 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin

Imai, M, Kuwahara, M, Ishibashi, K, Sasaki, S, Morinaga, T

Biochim Biophys Acta 2002
18678926 Compartmentalization of aquaporins in the human intestine

Isokpehi, R, Rajnarayanan, RV, Cohly, HH

Int J Environ Res Public Health 2008
11573934 Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum

Ohshiro, K, Hatakeyama, S, Yaoita, E, Kamiie, JI, Yamamoto, T, Hatakeyama, K, Suda, T, Koyama, Y, Tani, T, Nihei, K, Yoshida, Y

Biochem Biophys Res Commun 2001
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ishii, M, Ohta, KY, Watanabe, J, Katano, T, Ohgusu, Y, Urano, K, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

McKillop, IH, Iannitti, DA, Banks, PM, Smeltz, AM, Padma, S

HPB (Oxford) 2009
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Kwon, T, Vajda, Z, Amiry-Moghaddam, M, Jensen, UB, Nejsum, LN, Elkjaer, M, Nielsen, S, Fr√łkiaer, J

Biochem Biophys Res Commun 2000
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Weremowicz, S, Hediger, MA, Tsukaguchi, H, Morton, CC

Am J Physiol 1999
Catalyst Activity

urea channel activity of AQP9,10 [plasma membrane]

Orthologous Events
Cross References
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