Reactome | HSPA8 [nucleoplasm]

HSPA8 [nucleoplasm]

Stable Identifier

R-HSA-5082380

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heat shock cognate 71 kDa protein, HSP7C_HUMAN, HSC70

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Locations in the PathwayBrowser for interactor UniProt:Q8IZP0 ABI1

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External Reference Information

External Reference

UniProt:P11142 HSPA8

Gene Names

HSPA8, HSC70, HSP73, HSPA10

Chain

initiator methionine:, chain:2-646

Reference Genes

BioGPS Gene:3312 HSPA8

COSMIC (genes):HSPA8 HSPA8

CTD Gene:3312 HSPA8

dbSNP Gene:3312 HSPA8

ENSEMBL:ENSG00000109971 HSPA8

HGNC:5241 HSPA8

KEGG:hsa:3312 HSPA8

Monarch:3312 HSPA8

NCBI Gene:3312 HSPA8

OMIM:600816 HSPA8

UCSC:P11142 HSPA8

Reference Transcript

Other Identifiers

11720916_s_at

11741210_a_at

11741211_x_at

11756622_a_at

11756623_at

11757115_s_at

11757166_at

11757167_x_at

11762261_x_at

1179_at

1180_g_at

16745525

16745561

17118860

208687_PM_x_at

208687_x_at

210338_PM_s_at

210338_s_at

221891_PM_x_at

221891_x_at

224187_PM_x_at

224187_x_at

2989994

3011035

3312

33820_g_at

3395420

3395421

3395422

3395423

3395424

3395425

3395426

3395427

3395428

3395429

3395430

3395431

3395432

3395433

3395434

3395435

3395436

3395437

3395438

3395439

3395440

3395441

3395442

3395443

3395444

3395445

3395446

3395447

3395448

3395449

3395450

3395451

3395452

3395453

3395454

3395455

3395456

3401658

4020036

4020040

4020043

4020046

40637_at

44833_s_at

73372_r_at

7952325

7952335

7952339

A_23_P24594

A_24_P177553

A_24_P287129

A_24_P295745

A_32_P13728

A_33_P3323463

A_33_P3346688

A_33_P3390758

GE79248

GO:0000082

GO:0000398

GO:0000974

GO:0001664

GO:0001786

GO:0001822

GO:0001916

GO:0001917

GO:0003723

GO:0003824

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005776

GO:0005829

GO:0005874

GO:0005882

GO:0005886

GO:0005925

GO:0006355

GO:0006397

GO:0006457

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0006986

GO:0007018

GO:0007519

GO:0008021

GO:0008088

GO:0008289

GO:0008380

GO:0009267

GO:0009410

GO:0009986

GO:0010045

GO:0010628

GO:0010667

GO:0014069

GO:0014823

GO:0016020

GO:0016071

GO:0016787

GO:0016887

GO:0019899

GO:0021549

GO:0022414

GO:0023026

GO:0030163

GO:0030335

GO:0030424

GO:0030425

GO:0030674

GO:0030900

GO:0031072

GO:0031410

GO:0031625

GO:0031647

GO:0031686

GO:0032279

GO:0032355

GO:0032570

GO:0032984

GO:0032991

GO:0034330

GO:0034605

GO:0034774

GO:0042026

GO:0042277

GO:0042470

GO:0042594

GO:0043025

GO:0043195

GO:0043197

GO:0043198

GO:0043202

GO:0043204

GO:0043226

GO:0043254

GO:0043531

GO:0044183

GO:0044309

GO:0044743

GO:0044788

GO:0044829

GO:0044849

GO:0045296

GO:0045471

GO:0045862

GO:0045892

GO:0046034

GO:0048018

GO:0048026

GO:0048471

GO:0048856

GO:0050766

GO:0051082

GO:0051085

GO:0051087

GO:0051726

GO:0055085

GO:0055086

GO:0055131

GO:0060090

GO:0061024

GO:0061077

GO:0061202

GO:0061635

GO:0061684

GO:0061738

GO:0061740

GO:0070062

GO:0070301

GO:0071276

GO:0071383

GO:0072318

GO:0072562

GO:0097214

GO:0098575

GO:0098684

GO:0098690

GO:0098772

GO:0098793

GO:0098794

GO:0098880

GO:0098978

GO:0099175

GO:0099523

GO:0099524

GO:0099634

GO:0101031

GO:0140104

GO:0140545

GO:0140597

GO:0140657

GO:0140662

GO:1900226

GO:1901135

GO:1902904

GO:1904589

GO:1904592

GO:1904593

GO:1904764

GO:1904813

GO:1990832

GO:1990833

GO:1990834

GO:1990836

GO:1990904

HMNXSV003014198

HMNXSV003019988

HMNXSV003023305

HMNXSV003039522

Hs.180414.3.A1_3p_a_at

ILMN_1686367

ILMN_1689294

ILMN_1754332

ILMN_2413084

PH_hs_0039202

PH_hs_0040139

RNA147239|p0343_imsncRNA763

RNA147242|p0346_imsncRNA765

TC11002390.hg

TC11002391.hg

TC11002392.hg

g11526572_3p_a_at

Participates

as an input of

METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Homo sapiens)

as a component of

as a member of

Other forms of this molecule

HSPA8 [cytosol]

HSPA8 [lysosomal lumen]

HSPA8 [late endosome lumen]

HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

HSPA8 [plasma membrane]

HSPA8 [secretory granule lumen]

HSPA8 [extracellular region]

HSPA8 [ficolin-1-rich granule lumen]

Me3K561-HSPA8 [nucleoplasm]

Inferred To

LOC607182 [nucleoplasm] (Canis familiaris)

ssa1 [nucleoplasm] (Schizosaccharomyces pombe)

Hsc70-4 [nucleoplasm] (Drosophila melanogaster)

HSPA8 [nucleoplasm] (Bos taurus)

HSPA8 [nucleoplasm] (Danio rerio)

HSPA8 [nucleoplasm] (Gallus gallus)

HSPA8 [nucleoplasm] (Mus musculus)

HSPA8 [nucleoplasm] (Plasmodium falciparum)

HSPA8 [nucleoplasm] (Rattus norvegicus)

HSPA8 [nucleoplasm] (Sus scrofa)

hspa8 [nucleoplasm] (Xenopus tropicalis)

hsp-1 [nucleoplasm] (Caenorhabditis elegans)

ssa2 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of HSPA8 [nucleoplasm] (Schizosaccharomyces pombe)

hspB [nucleoplasm] (Dictyostelium discoideum)

SSA2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_006588.1, XP_011541100.1, NP_694881.1

Guide to Pharmacology - Targets

2543

OpenTargets

ENSG00000109971

ENSEMBL

ENSP00000227378, ENST00000453788, ENSP00000404372, ENST00000532636, ENSP00000437125, ENSP00000432083, ENST00000227378, ENST00000534624

ZINC - Substances

HSP7C_HUMAN

ZINC - Biogenic

HSP7C_HUMAN

ZINC target

P11142

PRO

P11142

GlyGen

P11142

PDB

3FZL, 3FZK, 3FZH, 3AGZ, 3AGY, 5AQL, 5AQK, 3LDQ, 5AQS, 5AQT, 3FZF, 6B1I, 5AQR, 5AQI, 5AQJ, 5AQQ, 4H5W, 4H5N, 4H5V, 5AQO, 4H5T, 5AQP, 3ESK, 5AQG, 5AQH, 3M3Z, 5AQU, 4H5R, 5AQF, 6ZYJ, 5AQM, 6B1M, 6B1N, 5AQV, 5AQN, 4KBQ, 3FZM, 4HWI

ZINC - Metabolites

HSP7C_HUMAN

HPA

ENSG00000109971-HSPA8

Pharos - Targets

P11142

ZINC - Predictions - Purchasable

HSP7C_HUMAN

HMDB Protein

HMDBP13799

Interactors (160)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZL4 HPBP1			0.924	15
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.871	9
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.823	10
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.813	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.803	7
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.787	7
UniProt:O14976 GAK	3	GAK [cytosol] (R-HSA-8868619) GAK [Golgi membrane] (R-HSA-434340) GAK [cytoplasmic vesicle membrane] (R-HSA-434203)	0.763	9
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.719	13
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.718	6
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.709	5
UniProt:Q3B7T1 EDRF1			0.671	6
UniProt:O75165 DNAJC13	3	DNAJC13 [azurophil granule membrane] (R-HSA-6799140) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951)	0.671	6
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.671	5
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.671	9
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.671	6
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	4
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.669	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.667	6
UniProt:P54253 ATX1			0.666	13
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.666	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	6
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.664	5
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.659	4
UniProt:Q99592 ZBT18			0.643	3
UniProt:Q96CP2 FWCH2			0.643	3
UniProt:Q9NVT9 ARMC1			0.643	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.643	3
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.643	5
UniProt:P00338 LDHA	2	LDHA [cytosol] (R-HSA-70502) PolyUb-LDHA [cytosol] (R-HSA-9861549)	0.639	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	22
UniProt:P38260 FES1			0.61	4
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.597	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	3
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.573	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:Q9BQC3 DPH2	1	DPH2 [cytosol] (R-HSA-5358368)	0.569	4
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.569	3
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.569	5
UniProt:Q9BZG8 DPH1	1	DPH1 [cytosol] (R-HSA-5358384)	0.569	4
UniProt:O95757 HSPA4L	2	HSPA4L [cytosol] (R-HSA-5251943) HSPA4L [nucleoplasm] (R-HSA-5252053)	0.569	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	11
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.564	2
UniProt:Q9BQI3 EIF2AK1	3	p-T-EIF2AK1 [cytosol] (R-HSA-9648892) p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894) EIF2AK1 [cytosol] (R-HSA-9840382)	0.564	2
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.564	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.564	2
UniProt:P57723 PCBP4	1	PCBP4 [cytosol] (R-HSA-6803382)	0.564	2
UniProt:Q9H6T0 ESRP2	1	ESRP2 [nucleoplasm] (R-HSA-6803474)	0.564	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.564	2
UniProt:P01308-PRO_0000015820 INS			0.558	2
UniProt:P10636-6 MAPT			0.558	3
UniProt:P01893 HLA-H	8	HLA-H [phagocytic vesicle membrane] (R-HSA-8855901) HLA-H [recycling endosome membrane] (R-HSA-8863855) HLA-H [early endosome membrane] (R-HSA-8855898) HLA-H [ER to Golgi transport vesicle membrane] (R-HSA-8855892) HLA-H [Golgi membrane] (R-HSA-8855895) HLA-H [plasma membrane] (R-HSA-6806266) HLA-H [azurophil granule membrane] (R-HSA-6799339) HLA-H [lumenal side of endoplasmic reticulum membrane] (R-HSA-8855907)	0.558	2
UniProt:O60260-5 PRKN			0.556	9
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.547	2
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.547	2
UniProt:Q96MN9 ZN488			0.527	3
UniProt:Q9H9A6 LRC40			0.527	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.527	2
UniProt:P30679 GNA15	1	GNA15 [plasma membrane] (R-HSA-167450)	0.527	2
UniProt:Q9Y2I8 WDR37			0.527	5
UniProt:Q6ZMN8 CCNI2			0.527	2
UniProt:Q15555 MARE2			0.527	3
UniProt:P0DPA2 VSIG8			0.527	2
UniProt:Q9BXA7 TSSK1			0.527	2
UniProt:Q8IVL6 P3H3	1	LEPREL2 [endoplasmic reticulum lumen] (R-HSA-1650821)	0.527	2
UniProt:Q5TEC6 H37			0.527	2
UniProt:P40121 CAPG			0.527	2
UniProt:Q9Y6J9 TAF6L	1	TAF6L [nucleoplasm] (R-HSA-212393)	0.527	2
UniProt:Q53H47 SETMR			0.527	2
UniProt:P68871 HBB	8	HBB [lysosomal lumen] (R-HSA-9625193) HBB [cytosol] (R-HSA-1008196) HBB [late endosome lumen] (R-HSA-9631108) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [extracellular region] (R-HSA-2168872) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [endocytic vesicle lumen] (R-HSA-2230936) CO-H+-HBB [cytosol] (R-HSA-1237013)	0.527	2
UniProt:Q9UNU6 CYP8B1	1	CYP8B1 [endoplasmic reticulum membrane] (R-HSA-192012)	0.527	2
UniProt:Q96FZ2 HMCES			0.527	3
UniProt:P57076 CF298			0.527	3
UniProt:Q7L4E1 MIGA2	1	MIGA2 [mitochondrial outer membrane] (R-HSA-8954402)	0.527	2
UniProt:Q8IYG6 LRC56			0.527	3
UniProt:Q8TDN2 KCNV2	1	KCNV2 [plasma membrane] (R-HSA-977505)	0.527	2
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.527	2
UniProt:P53367 ARFP1			0.527	3
UniProt:Q8N4P2 IFT70B	2	TTC30B [ciliary tip] (R-HSA-5637970) TTC30B [cilium] (R-HSA-5637971)	0.527	2
UniProt:Q8N239 KLH34			0.527	3
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q6UXT9 ABH15			0.527	3
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	2
UniProt:Q6P158 DHX57			0.527	3
UniProt:A2VCK2 DCD2B			0.527	2
UniProt:Q6ZMP0 THSD4	3	THSD4 [endoplasmic reticulum lumen] (R-HSA-5173065) glc-fuc-THSD4 [endoplasmic reticulum lumen] (R-HSA-5173066) O-fuc-THSD4 [endoplasmic reticulum lumen] (R-HSA-5173088)	0.527	2
UniProt:Q2TAL8 QRIC1			0.527	3
UniProt:Q9H6K1 ILRUN			0.527	3
UniProt:Q9NVX7 KBTB4			0.527	2
UniProt:P55039 DRG2	2	3OHK21-DRG2 [cytosol] (R-HSA-9629595) DRG2 [cytosol] (R-HSA-9629597)	0.527	2
UniProt:P61011 SRP54	1	SRP54 [cytosol] (R-HSA-264977)	0.527	2
UniProt:Q309B1 TR16L			0.527	2
UniProt:Q96E22 NUS1	1	NUS1 [endoplasmic reticulum membrane] (R-HSA-6806946)	0.527	3
UniProt:Q8N4N3 KLH36			0.527	2
UniProt:Q9NZV8 KCND2	1	KCND2 [plasma membrane] (R-HSA-977453)	0.527	2
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	2
UniProt:Q9NYQ3 HAO2	2	HAO2 [cytosol] (R-HSA-9033093) HAO2 [peroxisomal matrix] (R-HSA-6787806)	0.527	2
UniProt:Q6JEL2 KLH10			0.527	3
UniProt:Q96DF8 ESS2			0.527	2
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.527	2
UniProt:P56555 DSCR4			0.527	2
UniProt:Q8N831 TSYL6			0.527	2
UniProt:Q14249 NUCG			0.527	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	3
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.527	2
UniProt:Q9UJ71 CD207	3	CD207 [early endosome membrane] (R-HSA-1236852) CD207 [clathrin-coated endocytic vesicle membrane] (R-HSA-1236762) CD207 [plasma membrane] (R-HSA-1216519)	0.527	2
UniProt:Q99742 NPAS1			0.527	3
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	2
UniProt:P63092 GNAS	1	GNAS2 [plasma membrane] (R-HSA-164387)	0.527	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.527	2
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	3
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:Q2T9J0 TYSND1	4	TYSND1(111-566) [peroxisomal matrix] (R-HSA-9033589) TYSND1(1-110) [peroxisomal matrix] (R-HSA-9033587) TYSND1 [peroxisomal matrix] (R-HSA-8933309) TYSND1 [cytosol] (R-HSA-9033586)	0.527	2
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.527	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	4
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.527	3
UniProt:Q9BYJ1 ALOXE3	1	ALOXE3 [cytosol] (R-HSA-8942204)	0.527	2
UniProt:A6NED2 RCCD1	2	3OHR141-RCCD1 [cytosol] (R-HSA-9629871) RCCD1 [cytosol] (R-HSA-9629873)	0.527	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.527	2
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.527	2
UniProt:Q96SI1 KCTD15	1	KCTD15 [nucleoplasm] (R-HSA-8864337)	0.527	2
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.527	2
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q15813 TBCE	1	TBCE [cytosol] (R-HSA-379539)	0.527	2
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:P02768 ALB	7	ALB(19-609) [extracellular region] (R-HSA-114609) ALB [platelet alpha granule lumen] (R-HSA-49865) salicyl-ALB [extracellular region] (R-HSA-9750694) acetyl-ALB [extracellular region] (R-HSA-9749660) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.527	2
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:Q99439 CNN2	3	CNN2 [tertiary granule lumen] (R-HSA-6800942) CNN2 [extracellular region] (R-HSA-6806300) CNN2 [specific granule lumen] (R-HSA-6799532)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.527	2
UniProt:P00748 F12	11	factor XII [plasma membrane] (R-HSA-158214) factor XIIa light chain [extracellular region] (R-HSA-158320) factor XIIa heavy chain [extracellular region] (R-HSA-158285) F12 T328K [plasma membrane] (R-HSA-9653238) F12 T328R [plasma membrane] (R-HSA-9653226) F12 T328R(20-328) [extracellular region] (R-HSA-9653225) F12 T328K(20-328) [extracellular region] (R-HSA-9653230) F12 T328K (329-615) [extracellular region] (R-HSA-9653252) F12 T328R (329-615) [extracellular region] (R-HSA-9653243) F12 T328R (373-615) [extracellular region] (R-HSA-9655055) F12 T328K (373-615) [extracellular region] (R-HSA-9655053)	0.527	3
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:P03485 M	6	M1 [plasma membrane] (R-FLU-195782) M1 [extracellular region] (R-FLU-169241) M1 [endocytic vesicle membrane] (R-FLU-189168) M1 [endosome lumen] (R-FLU-189155) M1 [cytosol] (R-FLU-169073) M1 [nucleoplasm] (R-FLU-186959)	0.524	4
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:P14598 NCF1	4	p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854) NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220)	0.499	2
UniProt:P61764 STXBP1	2	STXBP1 [plasma membrane] (R-HSA-2980862) STXBP1 [cytosol] (R-HSA-6794256)	0.499	2
UniProt:Q15131 CDK10			0.499	2
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.499	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4
UniProt:Q99IB8-PRO_0000045599			0.488	2
UniProt:O15013 ARHGEF10	1	ARHGEF10 [cytosol] (R-HSA-8873917)	0.483	3
UniProt:Q9H9T3 ELP3	1	ELP3 [nucleoplasm] (R-HSA-3318364)	0.483	2
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.482	2
UniProt:O95801 TTC4			0.482	2

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