HSP70:DNAJB1 binds HSF1

Stable Identifier
R-HSA-5082384
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HSP70:DNAJB1 binds HSF1
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During attenuation and recovery from heat shock, increased levels of HSP70 and HDJ1 (HSP40) were found to associate with the HSF1 activation domain, repressing its transcriptional activity (Shi Y et al. 1998)
Literature References
PubMed ID Title Journal Year
1607379 Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

Voellmy, R, Welch, WJ, Baler, R

J. Cell Biol. 1992
1628823 The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression

Murphy, SP, Morimoto, RI, Abravaya, K, Myers, MP

Genes Dev. 1992
9499401 Molecular chaperones as HSF1-specific transcriptional repressors

Shi, Y, Morimoto, RI, Mosser, DD

Genes Dev. 1998
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Orthologous Events
HSP70:DNAJB1 binds HSF1 (Bos taurus)
HSP70:DNAJB1 binds HSF1 (Canis familiaris)
HSP70:DNAJB1 binds HSF1 (Gallus gallus)
HSP70:DNAJB1 binds HSF1 (Mus musculus)
HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)
HSP70:DNAJB1 binds HSF1 (Sus scrofa)
Authored
Shamovsky, V  (2013-10-29)
Reviewed
Pani, B  (2014-02-17)
Created
Shamovsky, V  (2013-11-05)
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