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GAB2 [cytosol]
Stable Identifier
R-HSA-508239
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GRB2-associated-binding protein 2, GAB2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P29353%20SHC1
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3:GRB2 binds GAB2 (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
GAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQC2 GAB2
Gene Names
GAB2, KIAA0571
Chain
chain:1-676
Reference Genes
BioGPS Gene:9846 GAB2
COSMIC (genes):GAB2 GAB2
CTD Gene:9846 GAB2
dbSNP Gene:9846 GAB2
ENSEMBL:ENSG00000033327 GAB2
ENSEMBL_homo_sapiens_GENE:ENSG00000033327.13 GAB2
HGNC:14458 GAB2
KEGG Gene (Homo sapiens):9846 GAB2
Monarch:9846 GAB2
NCBI Gene:9846 GAB2
OMIM:606203 GAB2
UCSC:Q9UQC2 GAB2
Reference Transcript
RefSeq:NM_080491.2 GAB2
RefSeq:NM_012296.3 GAB2
RefSeq:XM_006718753.2 GAB2
Other Identifiers
11724867_a_at
11737624_a_at
16742647
203853_PM_s_at
203853_s_at
3383228
3383229
3383230
3383231
3383232
3383233
3383234
3383235
3383236
3383237
3383238
3383239
3383243
3383244
3383258
3383259
3383278
3383295
3383296
35253_at
7950671
9846
A_23_P203743
A_24_P98843
GE53283
GO:0002376
GO:0005068
GO:0005515
GO:0005547
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007169
GO:0008284
GO:0008289
GO:0016020
GO:0016192
GO:0023052
GO:0030154
GO:0030316
GO:0043306
GO:0043325
GO:0043491
GO:0045121
GO:0048856
GO:0060090
HMNXSV003056815
ILMN_1665964
ILMN_1728746
ILMN_1815758
PH_hs_0002620
TC11002136.hg
g6912459_3p_a_at
Participates
as an input of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)
FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
Active FLT3:GRB2 binds GAB2 (Homo sapiens)
Recruitment of GAB2 to PM and FCERI by binding to GRB2 (Homo sapiens)
as a component of
p-Y FLT3 fusions:GRB2:GAB2 [cytosol] (Homo sapiens)
p-6Y FLT3 mutant dimers:GRB2:GAB2 [plasma membrane] (Homo sapiens)
GRB2:GAB2 [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
Active FLT3:GRB2:GAB2 [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:GAB2 [plasma membrane] (Homo sapiens)
as a member of
GAB1,GAB2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y643-GAB2 [cytosol]
p-5Y-GAB2 [cytosol]
p-Y-GAB2 [cytosol]
p-Y452,Y476,Y584-GAB2 [cytosol]
Inferred To
Gab2 [cytosol]
(Mus musculus)
Gab2 [cytosol]
(Rattus norvegicus)
GAB2 [cytosol]
(Bos taurus)
GAB2 [cytosol]
(Canis familiaris)
GAB2 [cytosol]
(Gallus gallus)
GAB2 [cytosol]
(Sus scrofa)
gab2 [cytosol]
(Xenopus tropicalis)
dos [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_536739.1
,
XP_006718816.1
,
NP_036428.1
OpenTargets
ENSG00000033327
HPA
ENSG00000033327-GAB2
GeneCards
Q9UQC2
Ensembl
ENSP00000343959
,
ENST00000361507
,
ENST00000340149
,
ENSG00000033327
,
ENSP00000354952
PRO
Q9UQC2
Pharos - Targets
Q9UQC2
Orphanet
28320
PDB
2W0Z
,
6ZVC
,
6ZVE
,
5EXA
,
6ZVB
,
6ZVD
,
6Y3R
,
5EWZ
,
2VWF
,
6Y3S
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.95
15
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.745
6
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.706
6
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.706
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.671
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.669
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.649
6
UniProt:Q06124 PTPN11
4
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
0.643
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.615
6
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.564
2
UniProt:Q8WZ73-3 Q8WZ733
0.556
3
UniProt:Q96JP2 MY15B
0.556
3
UniProt:P11117 PPAL
0.556
3
UniProt:P08865 RPSA
2
RPSA [nucleoplasm]
(R-HSA-6798722)
RPSA [cytosol]
(R-HSA-72389)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.556
3
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.544
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
3
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