Gab2 binds the p85 subunit of Class 1A PI3 kinases

Stable Identifier
Reaction [transition]
Homo sapiens
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Shc promotes Gab2 tyrosine phosphorylation via Grb2 (Gu et al. 2000). This promotes binding of Gab2 to p85alpha, a component of Class 1A PI3Ks (Gu et al. 1998). JAK1 may also be involved in PI3K recruitment (Migone et al. 1998). Binding of p85 activates PI3K kinase activity, with consequent effects on many processes including Akt activation. This is one of two mechanisms described for the recruitment of PI3K to the IL-3/IL-5/GM-CSF receptors, the other is mediated by Serine-585 phosphorylation of the common beta chain.

Literature References
PubMed ID Title Journal Year
10455108 Engagement of Gab1 and Gab2 in erythropoietin signaling

Krystal, G, Ahmad, S, Chen, F, Sharma, A, Sawyer, ST, Platanias, LC, Nishada, K, Hirano, T, Hibi, M, Yi, T, Alsayed, Y, Uddin, S, Wickrema, A

J Biol Chem 1999
9885561 Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

Neel, BG, Pratt, JC, Gu, H, Burakoff, SJ

Mol Cell 1998
Orthologous Events
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