Reactome | BIRC2 [cytosol]

BIRC2 [cytosol]

Stable Identifier

R-HSA-50847

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

c-IAP1, Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B), Baculoviral IAP repeat-containing protein 2, Inhibitor of apoptosis protein 2, HIAP2, HIAP-2, TNFR2-TRAF signaling complex protein 2, IAP homolog B

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Locations in the PathwayBrowser for interactor UniProt:Q9NYW3 TAS2R7

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External Reference Information

External Reference

UniProt:Q13490 BIRC2

Gene Names

BIRC2, API1, MIHB, RNF48

Chain

chain:1-618

Reference Genes

BioGPS Gene:329 BIRC2

COSMIC (genes):BIRC2 BIRC2

CTD Gene:329 BIRC2

dbSNP Gene:329 BIRC2

ENSEMBL:ENSG00000110330 BIRC2

HGNC:590 BIRC2

KEGG:hsa:329 BIRC2

Monarch:329 BIRC2

NCBI Gene:329 BIRC2

OMIM:601712 BIRC2

UCSC:Q13490 BIRC2

Reference Transcript

Other Identifiers

11717627_a_at

11717628_a_at

11744694_a_at

11750887_a_at

11757937_s_at

16730540

202076_PM_at

202076_at

329

3346583

3346585

3346586

3346587

3346588

3346589

3346590

3346591

3346592

3346593

3346594

3346595

3346596

3346597

3346598

3346599

3346600

3346601

3346603

3346604

3346605

3346607

3346608

3346609

3346610

3346611

3346612

3346613

3346614

3346615

3346616

36578_at

7943424

86204_at

A_14_P109450

A_14_P124015

A_14_P129741

A_14_P131109

A_24_P115774

GE509117

GE59117

GO:0000209

GO:0001666

GO:0001741

GO:0001890

GO:0003713

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0006915

GO:0007166

GO:0007249

GO:0008270

GO:0009898

GO:0016740

GO:0030163

GO:0031398

GO:0032991

GO:0033209

GO:0034121

GO:0035631

GO:0038061

GO:0039535

GO:0042127

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043123

GO:0043124

GO:0043130

GO:0043161

GO:0044877

GO:0045088

GO:0045471

GO:0045595

GO:0045893

GO:0046872

GO:0048856

GO:0050727

GO:0051087

GO:0051591

GO:0051726

GO:0060544

GO:0060546

GO:0061630

GO:0070266

GO:0070424

GO:0071356

GO:0098770

GO:0140096

GO:1901222

GO:1902443

GO:1902523

GO:1902524

GO:1902527

GO:1902531

GO:1902916

GO:1904975

GO:2000377

HMNXSV003027101

ILMN_1768194

ILMN_2182704

PH_hs_0015035

TC11000957.hg

U37547_at

g10880127_3p_at

Participates

as a member of

as an input of

Caspase mediated cleavage of C-IAP1 (Homo sapiens)

as a component of

c-IAP1:UBE2D [cytosol] (Homo sapiens)

as a candidate of

RIP2 ubiquitin ligases [cytosol] (Homo sapiens)

Other forms of this molecule

K48pUb-BIRC2 [cytosol]

BIRC2(373-618) [cytosol]

BIRC2(1-372) [cytosol]

K63polyUb-BIRC2 [cytosol]

Inferred To

Diap2 [cytosol] (Drosophila melanogaster)

birc2 [cytosol] (Danio rerio)

birc2 [cytosol] (Xenopus tropicalis)

bir1 [cytosol] (Schizosaccharomyces pombe)

BIRC2 [cytosol] (Bos taurus)

BIRC2 [cytosol] (Canis familiaris)

BIRC2 [cytosol] (Gallus gallus)

BIRC2 [cytosol] (Sus scrofa)

Birc2 [cytosol] (Mus musculus)

Birc2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001243092.1, NP_001243095.1, NP_001157.1

Guide to Pharmacology - Targets

2791

OpenTargets

ENSG00000110330

ENSEMBL

ENST00000613397, ENST00000227758, ENSP00000431723, ENSG00000110330, ENST00000530675, ENSP00000477613, ENSP00000227758

ZINC - Substances

BIRC2_HUMAN

ZINC target

Q13490

PRO

Q13490

GlyGen

Q13490

PDB

4KMN, 3M1D, 7TRL, 3D9U, 6W8I, 4LGE, 7TRM, 1QBH, 3UW4, 4EB9, 5M6N, 4LGU, 4HY5, 6W74, 8DSO, 3D9T, 3OZ1, 4MTI, 6EXW, 6HPR, 2L9M, 4MU7, 3MUP, 3T6P, 4HY4, 6W7O, 8DSF, 7QGJ

ZINC - Investigational

BIRC2_HUMAN

GeneCards

BIRC2

HPA

ENSG00000110330-BIRC2

Pharos - Targets

Q13490

ZINC - Predictions - Purchasable

BIRC2_HUMAN

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.951	19
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.919	12
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.866	9
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.837	9
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.801	8
UniProt:Q96HA8 NTAQ1			0.801	8
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.798	8
UniProt:Q9Y3E2 BOLA1			0.781	7
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.77	10
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.725	5
UniProt:Q9NQT4 EXOSC5	3	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [nucleolus] (R-HSA-9935829)	0.718	6
UniProt:Q8N3J5 PPM1K	2	H139Hfs13* PPM1K [mitochondrial matrix] (R-HSA-9912515) PPM1K [mitochondrial matrix] (R-HSA-5693145)	0.718	6
UniProt:P08949-2 NMB			0.718	6
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.718	6
UniProt:P19438 TNFRSF1A	2	TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)	0.69	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.669	8
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.669	8
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.667	4
UniProt:Q9BZW7 TSG10			0.666	4
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.65	4
UniProt:Q9Y240 CLC11			0.643	4
UniProt:Q9BQK8 LPIN3	3	LPIN3 [endoplasmic reticulum membrane] (R-HSA-549160) LPIN3 [nuclear envelope] (R-HSA-4419928) p-S106-LPIN3 [nucleoplasm] (R-HSA-4419935)	0.643	4
UniProt:Q9NQ34 TMM9B			0.643	3
UniProt:Q86SG7 LYG2			0.643	4
UniProt:O75325 LRRN2			0.643	3
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.641	3
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)			0.618	4
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE			0.618	6
UniProt:P57078 RIPK4			0.602	3
UniProt:Q9Y572 RIPK3	8	RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3(329-518) [cytosol] (R-HSA-9686937) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933)	0.602	3
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.602	3
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.564	6
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.564	7
UniProt:P40325 HUA1			0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P08949 NMB	1	NMB(47-56) [extracellular region] (R-HSA-375361)	0.556	3
UniProt:Q06455-2 RUNX1T1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q01976	1	YSA1 [cytosol] (R-SCE-2393933)	0.556	3
UniProt:P38339	5	RGD1 [cytosol] (R-SCE-2976572-2) RGD1 [cytosol] (R-SCE-2976016-2) RGD1 [cytosol] (R-SCE-195145-2) RGD1 [extracellular region] (R-SCE-6806529-2) RGD1 [secretory granule lumen] (R-SCE-6804973-2)	0.556	3
UniProt:Q3E793 BOL1			0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9Y4C2-2 TCAF1			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.556	3
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:P51813 BMX	3	BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875) BMX(1-242) [cytosol] (R-HSA-351899)	0.556	3
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.553	6
UniProt:O75173 ADAMTS4	4	ADAMTS4 [extracellular region] (R-HSA-2533998) ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173253) glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5172994) O-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173144)	0.527	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [cytosol] (R-HSA-8875419) RABGEF1 [early endosome membrane] (R-HSA-2029032)	0.527	2
UniProt:Q9NYW3 TAS2R7	1	TAS2R7 [plasma membrane] (R-HSA-3299612)	0.527	2
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.527	2
UniProt:P19086 GNAZ	2	p-S27-GNAZ [plasma membrane] (R-HSA-804942) GNAZ [plasma membrane] (R-HSA-167416)	0.527	2
UniProt:P00736 C1R	3	C1R(18-705) [extracellular region] (R-HSA-173554) C1R N-terminal fragment [extracellular region] (R-HSA-173606) C1R C-terminal fragment [extracellular region] (R-HSA-173603)	0.527	3
UniProt:P30048 PRDX3	1	PRDX3 [mitochondrial matrix] (R-HSA-3323081)	0.527	2
UniProt:Q5T6F0 DCA12			0.527	4
UniProt:O75351 VPS4B	1	VPS4B [cytosol] (R-HSA-917719)	0.527	2
UniProt:Q86WC4 OSTM1	1	OSTM1 [lysosomal membrane] (R-HSA-2730944)	0.527	2
UniProt:P09341 CXCL1	3	CXCL1(35-107) [specific granule lumen] (R-HSA-6799624) CXCL1(35-107) [tertiary granule lumen] (R-HSA-6800931) CXCL1(35-107) [extracellular region] (R-HSA-373778)	0.527	3
UniProt:P58062 ISK7			0.527	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	3
UniProt:P20333 TNFRSF1B	3	TNFRSF1B(27-?) [plasma membrane] (R-HSA-6785037) TNFRSF1B [plasma membrane] (R-HSA-5661484) TNFRSF1B [specific granule membrane] (R-HSA-6806149)	0.527	2
UniProt:P17677 GAP43	2	PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482) GAP43 [plasma membrane] (R-HSA-452888)	0.527	2
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.527	2
UniProt:Q13114 TRAF3	4	K63polyUb-TRAF3 [cytosol] (R-HSA-936402) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.527	3
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.527	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.527	2
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.525	2
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.499	3
UniProt:Q9NP84 TNFRSF12A	1	TNFRSF12A [plasma membrane] (R-HSA-5675666)	0.499	2

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