Reactome | XIAP [cytosol]

XIAP [cytosol]

Stable Identifier

R-HSA-50849

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP, BIRC4

Locations in the PathwayBrowser for interactor UniProt:Q9Y2D8 ADIP

Expand all

External Reference Information

External Reference

UniProt:P98170 XIAP

Gene Names

XIAP, API3, BIRC4, IAP3

Chain

chain:1-497

Reference Genes

BioGPS Gene:331 XIAP

COSMIC (genes):XIAP XIAP

CTD Gene:331 XIAP

dbSNP Gene:331 XIAP

ENSEMBL:ENSG00000101966 XIAP

ENSEMBL_homo_sapiens_GENE:ENSG00000101966.14 XIAP

HGNC:592 XIAP

KEGG Gene (Homo sapiens):331 XIAP

Monarch:331 XIAP

NCBI Gene:331 XIAP

OMIM:300079 XIAP

UCSC:P98170 XIAP

Reference Transcript

Other Identifiers

11725698_x_at

11725699_at

11725700_s_at

11755086_x_at

11757039_a_at

17106723

206536_PM_s_at

206536_s_at

225858_3p_s_at

225858_PM_s_at

225858_s_at

225859_PM_at

225859_at

228363_PM_at

228363_at

235222_3p_x_at

235222_PM_x_at

235222_x_at

243026_PM_x_at

243026_x_at

3263489

331

3989687

3989688

3989689

3989690

3989696

3989697

3989698

3989699

3989700

3989701

3989703

3989704

3989705

3989706

3989707

3989708

51813_at

69767_at

78549_at

8169742

92143_r_at

A_14_P118310

A_23_P22460

A_33_P3246990

GO:0002376

GO:0003824

GO:0004842

GO:0004869

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006915

GO:0006954

GO:0006974

GO:0010804

GO:0012501

GO:0016055

GO:0016740

GO:0023052

GO:0030414

GO:0030510

GO:0031398

GO:0032481

GO:0036211

GO:0042127

GO:0042742

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043123

GO:0043154

GO:0043226

GO:0045088

GO:0046330

GO:0046872

GO:0050727

GO:0051402

GO:0051604

GO:0051726

GO:0055065

GO:0055070

GO:0060785

GO:0061135

GO:0061630

GO:0070424

GO:0070427

GO:0070431

GO:0070534

GO:0090263

GO:0097340

GO:0098542

GO:0098772

GO:0120283

GO:0140096

GO:1902530

HMNXSV003007420

Hs.201262.0.S1_3p_x_at

Hs.201262.1.S1_3p_a_at

Hs.321435.1.A1_3p_a_at

Hs.321435.1.A1_3p_at

Hs.5367.0.A1_3p_at

Hs2Affx.1.433.S1_3p_x_at

ILMN_1815361

PH_hs_0023989

PH_hs_0041066

TC0X000604.hg

TC0X001858.hg

g1016687_3p_a_at

Participates

as a member of

NEDD4,STUB1,WWP2 and XIAP [cytosol] (Homo sapiens)

as a candidate of

as a component of

as an input of

This entity regulates

Negatively

Other forms of this molecule

XIAP [nucleoplasm]

K48pUb-XIAP [cytosol]

Inferred To

XIAP [cytosol] (Bos taurus)

XIAP [cytosol] (Drosophila melanogaster)

XIAP [cytosol] (Mus musculus)

XIAP [cytosol] (Rattus norvegicus)

XIAP [cytosol] (Schizosaccharomyces pombe)

XIAP [cytosol] (Sus scrofa)

XIAP [cytosol] (Xenopus tropicalis)

BIRC4 [cytosol] (Canis familiaris)

IAP3 [cytosol] (Gallus gallus)

xiap [cytosol] (Danio rerio)

Homologues of XIAP [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_006724817.1, NP_001191330.1, NP_001158.2, XP_011529631.1

Guide to Pharmacology - Targets

2790

OpenTargets

ENSG00000101966

ZINC - Substances

XIAP_HUMAN

ZINC - Biogenic

XIAP_HUMAN

ZINC target

P98170

PRO

P98170

PDB

4WVS, 4J45, 1TFQ, 5C0K, 2ECG, 5C7C, 4J44, 1F9X, 4IC3, 5OQW, 2VSL, 3UW5, 5C7B, 5C3K, 4J3Y, 2POP, 5C7A, 5C83, 3UW4, 2JK7, 6GJW, 5C3H, 4KJV, 5C84, 1NW9, 4KJU, 2POI, 3EYL, 3CM7, 4J48, 8AZA, 6EY2, 5O6T, 2OPZ, 5M6E, 2OPY, 6QCI, 3CLX, 3CM2, 1I51, 8GH7, 5M6F, 3G76, 1KMC, 4MTZ, 1I4O, 1G3F, 5M6H, 4IC2, 8W59, 2KNA, 1G73, 4OXC, 5M6L, 4EC4, 1C9Q, 5M6M, 8W5A, 4WVU, 4J47, 4HY0, 4KMP, 4J46, 2QRA, 5C0L, 4WVT, 5C7D, 1I3O, 3HL5, 1TFT

ZINC - Investigational

XIAP_HUMAN

IntEnz

2.3.2.27

GeneCards

P98170

HPA

ENSG00000101966-XIAP

Ensembl

ENST00000355640, ENSP00000405529, ENSG00000101966, ENSP00000360242, ENST00000371199, ENST00000422098, ENSP00000347858

Pharos - Targets

P98170

Orphanet

16830

ZINC - Predictions - Purchasable

XIAP_HUMAN

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55211 CASP9	5	p-S196-CASP9(1-416) [cytosol] (R-HSA-198636) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-57033)	0.97	25
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.959	23
UniProt:O43353 RIPK2	2	RIPK2 [cytosol] (R-HSA-168402) Ub-209-RIPK2 [cytosol] (R-HSA-706483)	0.951	22
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.933	11
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.872	7
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.846	6
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.836	6
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.83	9
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.785	5
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.782	6
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.781	7
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.781	7
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.781	7
UniProt:P83105 HTRA4			0.764	11
UniProt:P83110-1 HTRA3			0.749	7
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.748	5
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.725	4
UniProt:Q96HA8 NTAQ1			0.712	4
UniProt:P83110 HTRA3			0.705	8
UniProt:O43447 PPIH	2	PPIH [nucleoplasm] (R-HSA-6806776) PPIH [cytosol] (R-HSA-9728791)	0.696	5
UniProt:Q9NR28-1 DIABLO			0.676	4
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.667	3
UniProt:Q9HC98 NEK6	2	NEK6 [cytosol] (R-HSA-2530596) p-S206-NEK6 [cytosol] (R-HSA-2984253)	0.666	4
UniProt:Q9Y2D8 ADIP			0.666	4
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.666	4
UniProt:P83110-2 HTRA3			0.661	6
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)			0.618	4
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE			0.618	6
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.602	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.602	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.591	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:P07686 HEXB	11	HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(316-556) [lysosomal lumen] (R-HSA-1605605) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(50-107) [lysosomal lumen] (R-HSA-9842398)	0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q06455-2 RUNX1T1			0.556	3
UniProt:Q01976	1	NUDT5 [cytosol] (R-SCE-2393933)	0.556	3
UniProt:Q3E793 BOL1			0.556	3
UniProt:Q9Y3E2 BOLA1			0.556	3
UniProt:Q8N3J5 PPM1K	2	H139Hfs13* PPM1K [mitochondrial matrix] (R-HSA-9912515) PPM1K [mitochondrial matrix] (R-HSA-5693145)	0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q92851-4 CASP10			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q92851 CASP10	4	CASP10(220-415) [cytosol] (R-HSA-933458) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-521) [cytosol] (R-HSA-933453)	0.556	3
UniProt:P57078 RIPK4			0.544	2
UniProt:O75173 ADAMTS4	4	ADAMTS4 [extracellular region] (R-HSA-2533998) ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173253) glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5172994) O-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173144)	0.527	3
UniProt:Q9Y240 CLC11			0.527	2
UniProt:Q96P09 BIRC8			0.527	3
UniProt:Q96IK5 GMCL1			0.527	2
UniProt:Q5T6F0 DCA12			0.527	3
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191)	0.527	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.527	2
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.527	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.527	3
UniProt:Q99623 PHB2	1	PHB2 [mitochondrial inner membrane] (R-HSA-8953721)	0.527	3
UniProt:O75325 LRRN2			0.527	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628) Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214)	0.527	2
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [cytosol] (R-HSA-206072)	0.527	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.524	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.519	2
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.508	2
UniProt:O14618 CCS	2	CCS [mitochondrial intermembrane space] (R-HSA-3777060) CCS [cytosol] (R-HSA-3299714)	0.499	2
UniProt:Q9JIQ3-PRO_0000021073 DIABLO			0.499	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.488	2

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