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BIRC5 [cytosol]
Stable Identifier
R-HSA-50851
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Survivin, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, Apoptosis inhibitor 4
Locations in the PathwayBrowser for interactor UniProt:Q7Z412 PEX26
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)
BIRC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15392 BIRC5
Gene Names
BIRC5, API4, IAP4
Chain
chain:1-142
Reference Genes
COSMIC (genes):BIRC5 BIRC5
dbSNP Gene:332 BIRC5
ENSEMBL:ENSG00000089685 BIRC5
Participates
as an input of
CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)
as a component of
SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
Other forms of this molecule
BIRC5 [nucleoplasm]
ub-BIRC5 [cytosol]
Inferred To
Ghost homologue of BIRC5 [cytosol]
(Mus musculus)
AFMID [cytosol]
(Canis familiaris)
Homologues of BIRC5 [cytosol]
(Caenorhabditis elegans)
BIRC5 [cytosol]
(Bos taurus)
BIRC5 [cytosol]
(Caenorhabditis elegans)
BIRC5 [cytosol]
(Gallus gallus)
BIRC5 [cytosol]
(Rattus norvegicus)
BIRC5 [cytosol]
(Saccharomyces cerevisiae)
BIRC5 [cytosol]
(Sus scrofa)
BIRC5 [cytosol]
(Xenopus tropicalis)
Det [cytosol]
(Drosophila melanogaster)
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q53HL2 CDCA8
3
polySUMO2,3-CDCA8 [cytosol]
(R-HSA-4655328)
CDCA8 [nucleoplasm]
(R-HSA-4655357)
CDCA8 [cytosol]
(R-HSA-375288)
0.964
21
UniProt:Q96GD4 AURKB
3
AURKB [cytosol]
(R-HSA-174231)
AURKB [nucleoplasm]
(R-HSA-4655360)
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
0.952
13
UniProt:Q9NQS7 INCENP
2
INCENP [nucleoplasm]
(R-HSA-4655393)
INCENP [cytosol]
(R-HSA-375311)
0.918
11
IntAct:EBI-15634422 H3K9-2
0.76
8
UniProt:Q9UQB9 AURKC
0.739
10
ChEBI:78766 LLP-3
0.642
4
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.635
7
IntAct:EBI-15949926 HSGO1
0.618
3
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.609
2
UniProt:Q86XJ1 GA2L3
0.558
4
IntAct:EBI-15963608 SMACN
0.558
2
UniProt:O43504 LAMTOR5
1
LAMTOR5 [lysosomal membrane]
(R-HSA-5655441)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q13148 TADBP
0.556
6
UniProt:Q92870-2 Q928702
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.556
3
UniProt:Q9BXM7 PINK1
5
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
0.556
3
UniProt:Q15834 CC85B
0.556
3
UniProt:Q8TB36 GDAP1
2
GDAP1 [peroxisomal membrane]
(R-HSA-9603788)
GDAP1 [cytosol]
(R-HSA-9603796)
0.556
3
UniProt:Q7Z412 PEX26
2
PEX26 [cytosol]
(R-HSA-9603779)
PEX26 [peroxisomal membrane]
(R-HSA-9033092)
0.556
3
UniProt:P05067-2 APP
0.556
3
UniProt:P55211 CASP9
5
CASP9(1-416) [cytosol]
(R-HSA-57033)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(331-416) [cytosol]
(R-HSA-141639)
p-T412-CASP9(1-416) [cytosol]
(R-HSA-9627087)
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
0.536
2
UniProt:Q96A19 C102A
0.527
2
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.527
2
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.527
2
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.527
2
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.527
2
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.527
2
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.527
2
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.527
2
UniProt:Q0VGL1 LAMTOR4
1
LAMTOR4 [lysosomal membrane]
(R-HSA-5655432)
0.527
2
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.527
2
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.527
2
UniProt:P02008 HBAZ
0.527
2
UniProt:A1L4H1 SSC5D
1
SSC5D [extracellular region]
(R-HSA-8878615)
0.527
2
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.527
2
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [nucleoplasm]
(R-HSA-4655443)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.525
2
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.524
3
UniProt:O14980 XPO1
2
XPO1 [cytosol]
(R-HSA-165539)
XPO1 [nucleoplasm]
(R-HSA-165529)
0.524
2
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.463
6
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