DVL2 is phosphorylated by PKC

Stable Identifier
R-HSA-5138432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
WNT5A-dependent phosphorylation of DVL2 by PKC is required for the internalization of FZD4 (Chen et al, 2003; Yu et al, 2007). Endogenous PKC alpha beta and gamma co-immunoprecipitate with myc-DVL2, and phosphorylation increases the association with beta-arrestin 2 (ARRB2) (Chen et al, 2003).
Literature References
PubMed ID Title Journal Year
17199046 Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

Rual, JF, Yu, A, Vidal, M, Kirchhausen, T, Harada, Y, Tamai, K, He, X

Dev. Cell 2007
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, Ahn, S, Caron, MG, Barak, LS, Brown, J, Hu, LA, Lefkowitz, RJ, Nusse, R, Miller, WE, ten Berge, D

Science 2003
Participants
Participates
Catalyst Activity

protein kinase C activity of Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane]

Orthologous Events
Authored
Created
Cite Us!