Reactome | AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]

AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-5138448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Adaptor protein AP2A2

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - WNT5A-dependent internalization of FZD4 (Homo sapiens)
        
        WNT5A:FZD4 is endocytosed (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 complex large subunits [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94973 AP2A2

Gene Names

AP2A2, ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899

Chain

chain:1-939

Reference Genes

BioGPS Gene:161 AP2A2

COSMIC (genes):AP2A2 AP2A2

CTD Gene:161 AP2A2

dbSNP Gene:161 AP2A2

ENSEMBL:ENSG00000183020 AP2A2

HGNC:562 AP2A2

KEGG:hsa:161 AP2A2

Monarch:161 AP2A2

NCBI Gene:161 AP2A2

OMIM:607242 AP2A2

UCSC:O94973 AP2A2

Reference Transcript

Participates

as a member of

AP-2 complex large subunits [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

AP2A2(1-939) [endolysosome membrane]

AP2A2(1-939) [secretory granule membrane]

AP2A2(1-939) [ficolin-1-rich granule membrane]

AP2A2(1-939) [plasma membrane]

AP2A2(1-939) [cytosol]

Inferred To

Ap2a2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Ap2a2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

apa-2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

AP-2alpha [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

AP2A2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

AP2A2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Cross References

RefSeq

NP_001229766.1, NP_036437.1

ENSEMBL

ENST00000528815, ENST00000448903, ENSP00000431630, ENST00000332231, ENSP00000413234, ENSG00000183020, ENSP00000327694

OpenTargets

ENSG00000183020

GeneCards

AP2A2

HPA

ENSG00000183020-AP2A2

PRO

O94973

Pharos - Targets

O94973

GlyGen

O94973

HMDB Protein

HMDBP14130

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.643	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.569	4
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.527	2
UniProt:P42566 EPS15	2	EPS15 [cytosol] (R-HSA-182920) p-Y849 EPS15 [cytosol] (R-HSA-8867028)	0.527	2
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.499	2

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