Reactome | WNT5A:FZD4 is endocytosed

WNT5A:FZD4 is endocytosed

Stable Identifier

R-HSA-5138459

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle, clathrin-coated endocytic vesicle membrane, cytosol

ReviewStatus

5/5

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WNT5A-dependent FZD4 uptake into clathrin-coated vesicles depends upon AP-2 and possibly ARBB2 (Chen et al, 2003; Yu et al, 2007). Evidence suggests that ARBB2 dissociates from the receptor-ligand complex before internalization (Chen et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
17199046	Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling Rual, JF, Yu, A, Vidal, M, Kirchhausen, T, Harada, Y, Tamai, K, He, X	Dev. Cell	2007
12958364	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 Chen, W, Ahn, S, Caron, MG, Barak, LS, Brown, J, Hu, LA, Lefkowitz, RJ, Nusse, R, Miller, WE, ten Berge, D	Science	2003