Reactome | GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Stable Identifier

R-HSA-514604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16359702	Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP Deng, Y, Qiu, R, Gu, X, Chen, F, Li, J, Xie, Y, Wei, Z, Mao, Y, Gong, W, Ji, C, Zheng, M	J Mol Biol	2006
12009299	NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties Gu, S, Deng, Y, Wang, Y, Huang, Y, Ying, K, Gu, X, Xie, Y, Mao, Y, Ji, C, Xu, Y, Li, Y, Wang, Z	Int J Biochem Cell Biol	2002
218932	Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators Miller, RL, Jones, TE, Spector, T	J Biol Chem	1979