Reactome | NCBP2 [nucleoplasm]

NCBP2 [nucleoplasm]

Stable Identifier

R-HSA-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CBP20, 20 kDa nuclear cap binding protein (NCBP 20 kDa subunit) (CBP20) (NCBP interacting protein 1) (NIP1), 20 kDa nuclear cap binding protein, NCBP 20 kDa subunit, NCBP interacting protein 1, NIP1

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR2 in disease (Homo sapiens)
      - FGFR2 mutant receptor activation (Homo sapiens)
        
        Signaling by FGFR2 IIIa TM (Homo sapiens)
        
        Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        Formation of HIV elongation complex in the absence of HIV Tat (Homo sapiens)
        
        Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Abortive elongation of HIV-1 transcript in the absence of Tat (Homo sapiens)
        
        Limited elongation of the HIV-1 transcript (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF:NELF:early elongation complex after limited nucleotide addition [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Separation of abortive HIV-1 transcript from template (Homo sapiens)
        
        DSIF:NELF:early elongation complex after limited nucleotide addition [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Early elongation complex with separated aborted transcript [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Formation of the HIV-1 Early Elongation Complex (Homo sapiens)
        
        Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (Homo sapiens)
        
        Aborted HIV-1 early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)
        
        HIV-1 capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        HIV-1 capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
        
        Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
        
        Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Pre-transcription Events (Homo sapiens)
    - Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)
      - Aborted early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
  - RNA Polymerase II Transcription Elongation (Homo sapiens)
    - Formation of RNA Pol II elongation complex (Homo sapiens)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
    - Formation of the Early Elongation Complex (Homo sapiens)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - Formation of DSIF:NELF:early elongation complex (Homo sapiens)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
    - Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Homo sapiens)
      - Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex [nucleoplasm] (Homo sapiens)
        
        Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP [nucleoplasm] (Homo sapiens)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20 [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
    - Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)
      - Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex [nucleoplasm] (Homo sapiens)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Homo sapiens)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Homo sapiens)
        
        NCBP2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52298 NCBP2

Gene Names

NCBP2, CBP20, PIG55

Chain

initiator methionine:1, chain:2-156

Reference Genes

COSMIC (genes):NCBP2 NCBP2

dbSNP Gene:22916 NCBP2

ENSEMBL:ENSG00000114503 NCBP2

Participates

as a component of

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)

as an input of

Formation of cap binding complex (CBC) (Homo sapiens)

Other forms of this molecule

NCBP2 [cytosol]

Inferred To

NCBP2 [nucleoplasm] (Bos taurus)

NCBP2 [nucleoplasm] (Caenorhabditis elegans)

NCBP2 [nucleoplasm] (Canis familiaris)

NCBP2 [nucleoplasm] (Danio rerio)

NCBP2 [nucleoplasm] (Dictyostelium discoideum)

NCBP2 [nucleoplasm] (Drosophila melanogaster)

NCBP2 [nucleoplasm] (Gallus gallus)

NCBP2 [nucleoplasm] (Mus musculus)

NCBP2 [nucleoplasm] (Plasmodium falciparum)

NCBP2 [nucleoplasm] (Rattus norvegicus)

NCBP2 [nucleoplasm] (Saccharomyces cerevisiae)

NCBP2 [nucleoplasm] (Schizosaccharomyces pombe)

NCBP2 [nucleoplasm] (Sus scrofa)

NCBP2 [nucleoplasm] (Xenopus tropicalis)

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.965	54
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.725	10
ChEBI:50210 7-METHYL-GTP			0.688	13
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.643	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.643	6
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.643	3
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.643	9
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	6
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.643	8
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.643	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.527	5
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q53F19 NCBP3			0.527	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	3
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.527	3
UniProt:P42285 MTREX	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.527	4
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:Q9NWB6 ARGL1			0.483	2
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.483	2

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