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TGFB1 [plasma membrane]
Stable Identifier
R-HSA-5146781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TGF-beta-1, Transforming Growth Factor beta 1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Virus Induced Apoptosis (Homo sapiens)
NA activation of TGF-beta (Homo sapiens)
Large latent complex of TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01137 TGFB1
Gene Names
TGFB1, TGFB
Chain
signal peptide:1-29, chain:30-278, chain:279-390
Reference Genes
BioGPS Gene:7040 TGFB1
COSMIC (genes):TGFB1 TGFB1
CTD Gene:7040 TGFB1
dbSNP Gene:7040 TGFB1
ENSEMBL:ENSG00000105329 TGFB1
ENSEMBL_homo_sapiens_GENE:ENSG00000105329.11 TGFB1
HGNC:11766 TGFB1
KEGG Gene (Homo sapiens):7040 TGFB1
Monarch:7040 TGFB1
NCBI Gene:7040 TGFB1
OMIM:190180 TGFB1
UCSC:P01137 TGFB1
Reference Transcript
RefSeq:NM_000660.6 TGFB1
Other Identifiers
11716385_at
11723396_at
1634_s_at
16872551
1830_s_at
203084_PM_at
203084_at
203085_PM_s_at
203085_s_at
219766_PM_at
219766_at
3863028
3863029
3863030
3863032
3863033
3863035
3863036
3863037
3863038
3863039
3863040
3863047
3863048
41445_at
7040
76345_r_at
8037005
A_23_P218476
A_24_P96171
GE59644
GO:0000122
GO:0000278
GO:0000902
GO:0001570
GO:0001657
GO:0001666
GO:0001763
GO:0001775
GO:0001837
GO:0001843
GO:0001933
GO:0002028
GO:0002040
GO:0002062
GO:0002069
GO:0002244
GO:0002248
GO:0002376
GO:0002460
GO:0002513
GO:0002859
GO:0003013
GO:0003179
GO:0003180
GO:0003823
GO:0005114
GO:0005125
GO:0005160
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005794
GO:0005796
GO:0005886
GO:0005902
GO:0005975
GO:0006310
GO:0006351
GO:0006355
GO:0006611
GO:0006754
GO:0006796
GO:0006874
GO:0006886
GO:0006913
GO:0006954
GO:0007010
GO:0007155
GO:0007179
GO:0007219
GO:0007406
GO:0007435
GO:0007492
GO:0007507
GO:0007565
GO:0008083
GO:0008283
GO:0008284
GO:0008285
GO:0008354
GO:0009410
GO:0009611
GO:0009749
GO:0009986
GO:0010033
GO:0010467
GO:0010468
GO:0010575
GO:0010628
GO:0010629
GO:0010716
GO:0010718
GO:0010742
GO:0010763
GO:0010936
GO:0012501
GO:0014003
GO:0014008
GO:0014070
GO:0016192
GO:0016202
GO:0017015
GO:0019899
GO:0021915
GO:0022408
GO:0022414
GO:0023052
GO:0030141
GO:0030154
GO:0030198
GO:0030214
GO:0030217
GO:0030279
GO:0030308
GO:0030312
GO:0030316
GO:0030334
GO:0030335
GO:0030424
GO:0030879
GO:0031012
GO:0031047
GO:0031065
GO:0031093
GO:0031100
GO:0031293
GO:0031334
GO:0031410
GO:0031536
GO:0032355
GO:0032570
GO:0032667
GO:0032700
GO:0032740
GO:0032755
GO:0032760
GO:0032801
GO:0032930
GO:0032943
GO:0032956
GO:0032967
GO:0033280
GO:0034330
GO:0034616
GO:0034713
GO:0034714
GO:0035066
GO:0035307
GO:0035800
GO:0035902
GO:0036211
GO:0036446
GO:0042060
GO:0042098
GO:0042110
GO:0042127
GO:0042130
GO:0042306
GO:0042307
GO:0042475
GO:0042482
GO:0042552
GO:0042802
GO:0043025
GO:0043029
GO:0043065
GO:0043117
GO:0043123
GO:0043129
GO:0043226
GO:0043410
GO:0043536
GO:0043537
GO:0043539
GO:0044877
GO:0045066
GO:0045216
GO:0045589
GO:0045591
GO:0045596
GO:0045599
GO:0045662
GO:0045742
GO:0045786
GO:0045892
GO:0045893
GO:0045944
GO:0046716
GO:0048018
GO:0048146
GO:0048286
GO:0048298
GO:0048535
GO:0048565
GO:0048642
GO:0048661
GO:0048839
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050680
GO:0050714
GO:0050729
GO:0050731
GO:0050765
GO:0050832
GO:0050868
GO:0050921
GO:0051152
GO:0051247
GO:0051280
GO:0051402
GO:0051726
GO:0051781
GO:0051897
GO:0055010
GO:0055065
GO:0055085
GO:0055086
GO:0055091
GO:0060070
GO:0060312
GO:0060325
GO:0060364
GO:0060391
GO:0060435
GO:0060744
GO:0060751
GO:0060762
GO:0061035
GO:0061298
GO:0061448
GO:0061520
GO:0062023
GO:0065003
GO:0070168
GO:0070173
GO:0070306
GO:0070374
GO:0070723
GO:0071260
GO:0071333
GO:0071363
GO:0071404
GO:0071456
GO:0071479
GO:0071549
GO:0071560
GO:0071677
GO:0071895
GO:0072089
GO:0072562
GO:0072659
GO:0085029
GO:0090190
GO:0090263
GO:0097191
GO:0097421
GO:0098542
GO:0098586
GO:0098772
GO:0140014
GO:1900126
GO:1900182
GO:1901135
GO:1901203
GO:1902074
GO:1902462
GO:1902894
GO:1902895
GO:1903077
GO:1904018
GO:1904894
GO:1990314
GO:1990402
GO:2000343
GO:2000353
GO:2000636
GO:2000648
GO:2000727
HMNXSV003021647
HMNXSV003021863
ILMN_1806999
ILMN_2129668
M38449_s_at
TC19001553.hg
TC19002485.hg
X05839_rna1_s_at
g10863872_3p_at
g12652748_3p_a_at
g13385567_3p_at
Participates
as a member of
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
as a component of
Large latent complex of TGFB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
TGFB1 [extracellular region]
TGFB1(30-278) [extracellular region]
TGFB1(30-278) [Golgi lumen]
TGFB1 [Golgi lumen]
TGFB1(30-390) [Golgi lumen]
TGFB1(30-278) [platelet alpha granule lumen]
Inferred To
daf-7 [plasma membrane]
(Caenorhabditis elegans)
tgfb1a [plasma membrane]
(Danio rerio)
mav [plasma membrane]
(Drosophila melanogaster)
Homologues of TGFB1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of TGFB1 [plasma membrane]
(Drosophila melanogaster)
B9D2 [plasma membrane]
(Canis familiaris)
TGFB1 [plasma membrane]
(Bos taurus)
TGFB1 [plasma membrane]
(Gallus gallus)
TGFB1 [plasma membrane]
(Sus scrofa)
Tgfb1 [plasma membrane]
(Mus musculus)
Tgfb1 [plasma membrane]
(Rattus norvegicus)
dpp [plasma membrane]
(Drosophila melanogaster)
unc-129 [plasma membrane]
(Caenorhabditis elegans)
dbl-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000651.3
OpenTargets
ENSG00000105329
ZINC - Substances
TGFB1_HUMAN
GeneCards
P01137
ZINC target
P01137
Ensembl
ENST00000221930
,
ENSG00000105329
,
ENSP00000221930
PRO
P01137
Pharos - Targets
P01137
Orphanet
15606
ZINC - Predictions - Purchasable
TGFB1_HUMAN
HMDB Protein
HMDBP14566
PDB
1KLC
,
3KFD
,
7Y1T
,
5FFO
,
6OM2
,
4KV5
,
6P7J
,
1KLD
,
1KLA
,
7Y1R
,
5VQP
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.886
11
UniProt:Q14392 LRC32
0.669
4
UniProt:Q14766-1 LTBP1
0.637
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.604
3
UniProt:P11464 PSG1
1
PSG1 [extracellular region]
(R-HSA-8870766)
0.558
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:O60711 LPXN
0.556
3
UniProt:Q5TA81 LCE2C
1
LCE2C [cytosol]
(R-HSA-6814284)
0.556
3
UniProt:O14633 LCE2B
1
LCE2B [cytosol]
(R-HSA-6814295)
0.556
3
IntAct:EBI-22335676 CCSB ORF ID
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:Q9BYE3 LCE3D
1
LCE3D [cytosol]
(R-HSA-6814297)
0.556
3
UniProt:Q5T751 LCE1C
1
LCE1C [cytosol]
(R-HSA-6814267)
0.556
3
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q5T7P2 LCE1A
1
LCE1A [cytosol]
(R-HSA-6814305)
0.556
3
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.556
3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q5TA77 LCE3B
1
LCE3B [cytosol]
(R-HSA-6814269)
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P22105 TNXB
1
TNXB [extracellular region]
(R-HSA-2672026)
0.544
3
UniProt:Q12841 FSTL1
3
FSTL1 [extracellular region]
(R-HSA-201832)
p-FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8957089)
FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8956749)
0.544
2
UniProt:Q86YC3 LRC33
0.527
2
UniProt:Q8IWV7 UBR1
1
UBR1 [cytosol]
(R-HSA-976040)
0.527
4
UniProt:P11047 LAMC1
3
p-LAMC1 [endoplasmic reticulum lumen]
(R-HSA-8956921)
LAMC1 [endoplasmic reticulum lumen]
(R-HSA-8956712)
LAMC1 [extracellular region]
(R-HSA-215962)
0.527
4
UniProt:O15496 PLA2G10
1
PLA2G10 [extracellular region]
(R-HSA-1498793)
0.527
2
UniProt:Q9BS26 ERP44
2
ERP44 [extracellular region]
(R-HSA-6806302)
ERP44 [specific granule lumen]
(R-HSA-6799567)
0.527
3
UniProt:P59665 DEFA1
9
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
0.527
2
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.527
3
UniProt:P07996 THBS1
5
THBS1 [extracellular region]
(R-HSA-66518)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
0.525
2
UniProt:P01137 TGFB1
7
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [Golgi lumen]
(R-HSA-9736812)
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.522
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.488
2
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