Reactome | CD9 [plasma membrane]

CD9 [plasma membrane]

Stable Identifier

R-HSA-51717

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

P24, Leukocyte antigen MIC3, Motility-related protein, MRP-1, CD9 antigen

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Locations in the PathwayBrowser for interactor UniProt:P62079 TSPAN5

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Literature References

PubMed ID	Title	Journal	Year
8194524	Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity Mekada, E, Taniguchi, N, Iwamoto, R, Klagsbrun, M, Mitamura, T, Higashiyama, S	EMBO J.	1994

External Reference Information

External Reference

UniProt:P21926 CD9

Gene Names

CD9, MIC3, TSPAN29, GIG2

Chain

initiator methionine:, chain:2-228

Reference Genes

BioGPS Gene:928 CD9

COSMIC (genes):CD9 CD9

CTD Gene:928 CD9

dbSNP Gene:928 CD9

ENSEMBL:ENSG00000010278 CD9

ENSEMBL_homo_sapiens_GENE:ENSG00000010278.15 CD9

HGNC:1709 CD9

KEGG Gene (Homo sapiens):928 CD9

Monarch:928 CD9

NCBI Gene:928 CD9

OMIM:143030 CD9

UCSC:P21926 CD9

Reference Transcript

Other Identifiers

11715568_a_at

11715569_at

11715570_x_at

11746940_a_at

11763854_a_at

11763855_x_at

16747184

201005_PM_at

201005_at

3402318

3402319

3402320

3402321

3402322

3402335

3402337

3402339

3402341

3402343

3402347

3402350

3402351

3402352

39389_at

7953291

928

A_14_P120677

A_14_P129314

A_23_P76364

GE79033

GO:0002376

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0007155

GO:0007338

GO:0007342

GO:0008283

GO:0008285

GO:0008347

GO:0009897

GO:0009986

GO:0014905

GO:0016020

GO:0016192

GO:0022414

GO:0030154

GO:0030168

GO:0030666

GO:0030669

GO:0030913

GO:0031092

GO:0031410

GO:0031623

GO:0032991

GO:0034330

GO:0035036

GO:0042060

GO:0043226

GO:0048856

GO:0048870

GO:0061024

GO:0070062

GO:0071404

GO:0090331

GO:1903561

GO:1905521

HMNXSV003037369

HMNXSV003043182

ILMN_1695423

M38690_at

PH_hs_0024428

TC12000076.hg

g4502692_3p_x_at

Participates

as a component of

as an input of

as a member of

Platelet alpha granule membrane components that are released on degranulation [plasma membrane] (Homo sapiens)

Other forms of this molecule

CD9 [endocytic vesicle membrane]

CD9 [clathrin-coated endocytic vesicle membrane]

CD9 [platelet alpha granule membrane]

Inferred To

Cd9 [plasma membrane] (Mus musculus)

Cd9 [plasma membrane] (Rattus norvegicus)

Tsp42En [plasma membrane] (Drosophila melanogaster)

cd9 [plasma membrane] (Xenopus tropicalis)

tsp-11 [plasma membrane] (Caenorhabditis elegans)

Tsp96F [plasma membrane] (Drosophila melanogaster)

CD9 [plasma membrane] (Bos taurus)

CD9 [plasma membrane] (Canis familiaris)

CD9 [plasma membrane] (Gallus gallus)

CD9 [plasma membrane] (Sus scrofa)

Tsp42Eg [plasma membrane] (Drosophila melanogaster)

Homologues of CD9 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001760.1, NP_001317241.1

OpenTargets

ENSG00000010278

HPA

ENSG00000010278-CD9

GeneCards

P21926

Ensembl

ENSP00000009180, ENSG00000010278, ENST00000538834, ENST00000009180, ENST00000382518, ENSP00000496639, ENSP00000371958

PRO

P21926

Pharos - Targets

P21926

PDB

6RLO, 6Z1V, 6Z20, 6K4J, 6RLR

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2B2 FPRP			0.859	11
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.758	7
UniProt:Q969P0 IGSF8			0.758	7
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.752	17
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.69	4
UniProt:O75954 TSN9			0.597	3
UniProt:P08195 SLC3A2	1	SLC3A2 [plasma membrane] (R-HSA-352179)	0.597	3
UniProt:Q8NG11 TSPAN14	4	TSPAN14 [endoplasmic reticulum lumen] (R-HSA-9010066) TSPAN14 [specific granule membrane] (R-HSA-6799708) TSPAN14 [plasma membrane] (R-HSA-6800467) TSPAN14 [tertiary granule membrane] (R-HSA-6800899)	0.597	4
UniProt:P02786 TFRC	5	TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829)	0.597	3
UniProt:P78536 ADAM17	6	ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [plasma membrane] (R-HSA-179878)	0.597	3
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.597	7
UniProt:P23229 ITGA6	1	ITGA6(24-1130) [plasma membrane] (R-HSA-204439)	0.597	3
UniProt:Q2M2E3 ODFP4			0.556	3
UniProt:P43121 MCAM	1	MCAM [plasma membrane] (R-HSA-197922)	0.527	2
UniProt:Q8WWI5 SLC44A1	2	SLC44A1 [mitochondrial outer membrane] (R-HSA-6798157) SLC44A1 [plasma membrane] (R-HSA-444456)	0.527	2
UniProt:P08473 MME	2	MME [plasma membrane] (R-HSA-2022342) MME [secretory granule membrane] (R-HSA-6806156)	0.499	6
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
UniProt:O75054 IGSF3			0.462	2
UniProt:Q8NCG7 DAGLB	1	DAGLB [plasma membrane] (R-HSA-426020)	0.462	2
UniProt:Q9NT68 TEN2			0.462	2
UniProt:P50895 BCAM			0.462	3
UniProt:P26006 ITGA3	1	ITGA3(33-1051) [plasma membrane] (R-HSA-204441)	0.462	6
UniProt:Q9P273 TEN3			0.462	2
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.462	2
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.462	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2
UniProt:P05026 ATP1B1	1	ATP1B1 [plasma membrane] (R-HSA-375071)	0.462	2
UniProt:P36021 SLC16A2	1	SLC16A2 [plasma membrane] (R-HSA-5216020)	0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:O95490 AGRL2			0.462	2
UniProt:P62079 TSPAN5	2	TSPAN5 [plasma membrane] (R-HSA-9010031) TSPAN5 [endoplasmic reticulum lumen] (R-HSA-9010081)	0.462	5
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.462	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.462	2
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.462	2
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.462	2
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.462	2
UniProt:P50281 MMP14	4	MMP14 [Golgi membrane] (R-HSA-9858808) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.462	2
UniProt:Q14118 DAG1	10	GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.462	2
UniProt:P16070 CD44	2	CD44 [secretory granule membrane] (R-HSA-6804776) CD44 [plasma membrane] (R-HSA-1031688)	0.462	2

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