Reactome | glc-fuc-THBS1 [endoplasmic reticulum lumen]

glc-fuc-THBS1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-5172997

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

O-fuc-THBS1, THBS1, Thrombospondin 1, TSP1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07996 THBS1

Gene Names

THBS1, TSP-1, Thrombospondin-1, TSP, TSP1

Chain

signal peptide:1-18, chain:19-1170

Reference Genes

BioGPS Gene:7057 THBS1

COSMIC (genes):THBS1 THBS1

CTD Gene:7057 THBS1

dbSNP Gene:7057 THBS1

ENSEMBL:ENSG00000137801 THBS1

HGNC:11785 THBS1

KEGG:hsa:7057 THBS1

Monarch:7057 THBS1

NCBI Gene:7057 THBS1

OMIM:188060 THBS1

UCSC:P07996 THBS1

Reference Transcript

RefSeq:NM_003246.3 THBS1

Participates

as a member of

glc-fuc-proteins [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

THBS1 [platelet alpha granule lumen]

THBS1 [extracellular region]

O-fuc-THBS1 [endoplasmic reticulum lumen]

THBS1 [endoplasmic reticulum lumen]

Inferred To

Thbs1 [endoplasmic reticulum lumen] (Mus musculus)

Thbs1 [endoplasmic reticulum lumen] (Rattus norvegicus)

glc-fuc-THBS1 [endoplasmic reticulum lumen] (Gallus gallus)

tmn [endoplasmic reticulum lumen] (Drosophila melanogaster)

Homologues of glc-fuc-THBS1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Tsp [endoplasmic reticulum lumen] (Drosophila melanogaster)

THBS1 [endoplasmic reticulum lumen] (Bos taurus)

THBS1 [endoplasmic reticulum lumen] (Canis familiaris)

THBS1 [endoplasmic reticulum lumen] (Sus scrofa)

thbs1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

O-fucosyl-L-serine (ChEBI:76521) at unknown position

Modification

beta-D-glucosyl-(1->3)-alpha-L-fucosyl group

PsiMod Name

O-fucosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to an O-fucosylserine.

Cross References

OpenTargets

ENSG00000137801

ENSEMBL

ENSP00000260356, ENST00000260356, ENSG00000137801

HPA

ENSG00000137801-THBS1

GeneCards

THBS1

PRO

P07996

Pharos - Targets

P07996

GlyGen

P07996

PDB

1ZA4, 5FOE, 1Z78, 1LSL, 7YYK, 3R6B, 2ERF, 1UX6, 2OUH, 2ES3, 2OUJ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
ChEBI:28304 HEPARIN			0.702	4
heparan sulfate [ChEBI:28815]	1	HS [extracellular region] (R-ALL-190915)	0.609	2
ChEBI:18376 DERMATAN			0.609	2
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.609	2
UniProt:Q15113 PCOLCE	1	PCOLCE [extracellular region] (R-HSA-2002444)	0.558	3
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2
UniProt:P55899 FCGRN			0.527	2
UniProt:P35442 THBS2	4	THBS2 [endoplasmic reticulum lumen] (R-HSA-5173187) glc-fuc-THBS2 [endoplasmic reticulum lumen] (R-HSA-5173234) O-fuc-THBS2 [endoplasmic reticulum lumen] (R-HSA-5173111) THBS2 [extracellular region] (R-HSA-66520)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936) TGFB1 [plasma membrane] (R-HSA-5146781)	0.525	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	3

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