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CSF2 [extracellular region]
Stable Identifier
R-HSA-517562
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Granulocyte-macrophage colony-stimulating factor, CSF2_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P01023 A2M
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells (Homo sapiens)
CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)
CSF2 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)
CSF2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04141 CSF2 gene
Gene Names
CSF2 gene, CSF2, GMCSF
Chain
signal peptide:1-17, chain:18-144
Reference Genes
BioGPS Gene:1437 CSF2 gene
CTD Gene:1437 CSF2 gene
dbSNP Gene:1437 CSF2 gene
ENSEMBL:ENSG00000164400 CSF2 gene
ENSEMBL_homo_sapiens_GENE:ENSG00000164400.6 CSF2 gene
HGNC:2434 CSF2 gene
KEGG Gene (Homo sapiens):1437 CSF2 gene
Monarch:1437 CSF2 gene
NCBI Gene:1437 CSF2 gene
OMIM:138960 CSF2 gene
UCSC:P04141 CSF2 gene
Reference Transcript
RefSeq:NM_000758.3 CSF2 gene
Other Identifiers
11728876_at
1400_at
1401_g_at
1437
16988971
210229_PM_s_at
210229_s_at
2828357
2828358
2828359
2828360
2828361
2828362
2828363
8107887
A_23_P133408
GE80952
GO:0001821
GO:0001892
GO:0002376
GO:0005125
GO:0005129
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007259
GO:0008083
GO:0008283
GO:0008284
GO:0010468
GO:0010628
GO:0010744
GO:0012501
GO:0023052
GO:0030099
GO:0030154
GO:0030223
GO:0030224
GO:0030225
GO:0030335
GO:0030526
GO:0032747
GO:0034021
GO:0034405
GO:0036211
GO:0038157
GO:0042045
GO:0042127
GO:0042531
GO:0043011
GO:0043226
GO:0043231
GO:0045187
GO:0045892
GO:0048018
GO:0048856
GO:0048870
GO:0065003
GO:0070665
GO:0071222
GO:0071803
GO:0097011
GO:0097028
GO:0098772
GO:2001240
HMNXSV003019774
ILMN_1661861
M13207_at
TC05000629.hg
g181149_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
as an output of
CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)
as an input of
GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)
as a component of
GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of CSF2 [extracellular region]
(Gallus gallus)
Csf2 [extracellular region]
(Mus musculus)
Csf2 [extracellular region]
(Rattus norvegicus)
CSF2 [extracellular region]
(Bos taurus)
CSF2 [extracellular region]
(Canis familiaris)
CSF2 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000749.2
GeneCards
P04141
HPA
ENSG00000164400-CSF2
Ensembl
ENSP00000296871
,
ENSG00000164400
,
ENST00000296871
PRO
P04141
Pharos - Targets
P04141
PDB
2GMF
,
6BFS
,
5C7X
,
5D71
,
4RS1
,
4NKQ
,
1CSG
,
5D72
,
6BFQ
,
5D70
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P50222 MEOX2
0.718
6
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
15
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.524
2
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