Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CDC7 [nucleoplasm]
Stable Identifier
R-HSA-51781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cdc7, Cell division protein kinase 7, Cell division cycle 7-related protein kinase (EC 2.7.1.-) (CDC7- related kinase) (HsCdc7) (huCdc7), Cell division cycle 7-related protein kinase , CDC7- related kinase, HsCdc7, huCdc7
Locations in the PathwayBrowser for interactor UniProt:Q9UKD1 GMEB2
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)
CDC7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00311 CDC7
Gene Names
CDC7, CDC7L1
Chain
chain:1-574
Reference Genes
BioGPS Gene:8317 CDC7
COSMIC (genes):CDC7 CDC7
CTD Gene:8317 CDC7
dbSNP Gene:8317 CDC7
ENSEMBL:ENSG00000097046 CDC7
HGNC:1745 CDC7
KEGG:hsa:8317 CDC7
Monarch:8317 CDC7
NCBI Gene:8317 CDC7
OMIM:603311 CDC7
UCSC:O00311 CDC7
Reference Transcript
RefSeq:XM_005271241.2 CDC7
RefSeq:NM_001134419.1 CDC7
RefSeq:NM_003503.3 CDC7
RefSeq:NM_001134420.1 CDC7
Other Identifiers
11732057_a_at
11732058_a_at
11750920_a_at
16667037
1809_at
204510_PM_at
204510_at
2346410
2346411
2346412
2346413
2346414
2346415
2346416
2346417
2346418
2346419
2346421
2346422
2346423
2346424
2346425
2346426
2346427
2346428
2346430
2346434
2346435
2346436
2346439
2346440
2346441
2346442
2346443
2346444
2346445
7902913
8317
AB003698_at
A_14_P138846
A_23_P148807
GE81291
GO:0000082
GO:0000727
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0006281
GO:0006310
GO:0006468
GO:0007165
GO:0008284
GO:0010571
GO:0010971
GO:0016301
GO:0016740
GO:0043226
GO:0044770
GO:0045171
GO:0046872
GO:0051301
GO:0072686
GO:0106310
GO:0140096
HMNXSV003002308
HMNXSV003022881
ILMN_1741801
PH_hs_0002521
TC01000846.hg
g11038647_3p_at
Participates
as an output of
CDC7 gene expression is repressed by the PRC1L4 complex (Homo sapiens)
as a component of
DDK [nucleoplasm] (Homo sapiens)
Inferred To
Cdc7 [nucleoplasm]
(Rattus norvegicus)
CDC7 [nucleoplasm]
(Bos taurus)
CDC7 [nucleoplasm]
(Caenorhabditis elegans)
CDC7 [nucleoplasm]
(Canis familiaris)
CDC7 [nucleoplasm]
(Gallus gallus)
CDC7 [nucleoplasm]
(Mus musculus)
CDC7 [nucleoplasm]
(Saccharomyces cerevisiae)
CDC7 [nucleoplasm]
(Schizosaccharomyces pombe)
CDC7 [nucleoplasm]
(Sus scrofa)
Ghost homologue of CDC7 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CDC7 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of CDC7 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_005271298.1
,
NP_003494.1
,
NP_001127892.1
,
NP_001127891.1
Guide to Pharmacology - Targets
1960
OpenTargets
ENSG00000097046
ENSEMBL
ENSP00000393139
,
ENST00000234626
,
ENSP00000234626
,
ENSG00000097046
,
ENST00000428239
ZINC - Substances
CDC7_HUMAN
ZINC target
O00311
PRO
O00311
GlyGen
O00311
PDB
6YA6
,
4F9A
,
6YA8
,
5UWQ
,
5UWR
,
4F9B
,
4F9C
,
6YA7
,
4F99
ZINC - Investigational
CDC7_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000097046-CDC7
GeneCards
CDC7
Pharos - Targets
O00311
ZINC - Predictions - Purchasable
CDC7_HUMAN
HMDB Protein
HMDBP09493
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBU7 DBF4
1
DBF4 [nucleoplasm]
(R-HSA-68387)
0.888
9
UniProt:Q9UBU7-1 DBF4
0.611
3
UniProt:Q9BTE3 MCMBP
0.589
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q2TAA8 TXIP1
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q9Y6T4 Q9Y6T4
0.556
3
UniProt:Q9NYA3 GOG6A
0.556
3
UniProt:Q9H2S9 IKZF4
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q8NAP8 ZBT8B
0.556
3
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q14140 SRTD2
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:P55061 BI1
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:Q9HCK0 ZBT26
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:Q96DT7-3 ZBTB10
0.556
3
UniProt:Q9UKD1 GMEB2
0.556
3
UniProt:O94972 TRIM37
1
TRIM37 [cytosol]
(R-HSA-976049)
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:P0CW01 TSPYA
0.556
3
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:Q6NT76 HMBX1
0.556
3
UniProt:Q9HBG6 IFT122
2
IFT122 [cilium]
(R-HSA-5610379)
IFT122 [ciliary tip]
(R-HSA-5625346)
0.508
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text