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Ub-p-S-PER2 [cytosol]
Stable Identifier
R-HSA-517835
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ub-p-PER2, Ubiquitinated Phosphorylated Period circadian protein homolog 2, PER2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins (Homo sapiens)
ub-p-PER1,ub-p-PER2 [cytosol] (Homo sapiens)
Ub-p-S-PER2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15055 PER2
Gene Names
PER2, KIAA0347
Chain
chain:1-1255
Reference Genes
BioGPS Gene:8864 PER2
COSMIC (genes):PER2 PER2
CTD Gene:8864 PER2
dbSNP Gene:8864 PER2
ENSEMBL:ENSG00000132326 PER2
ENSEMBL_homo_sapiens_GENE:ENSG00000132326.13 PER2
HGNC:8846 PER2
KEGG Gene (Homo sapiens):8864 PER2
Monarch:8864 PER2
NCBI Gene:8864 PER2
OMIM:603426 PER2
UCSC:O15055 PER2
Reference Transcript
RefSeq:NM_022817.2 PER2
RefSeq:XM_005246111.4 PER2
RefSeq:XM_006712824.3 PER2
Other Identifiers
11750155_a_at
11753100_a_at
11758315_s_at
11762382_x_at
16909958
205251_PM_at
205251_at
208518_PM_s_at
208518_s_at
2605750
2605751
2605752
2605753
2605754
2605755
2605756
2605757
2605758
2605759
2605760
2605762
2605764
2605765
2605768
2605771
2605772
2605774
2605776
2605778
2605780
2605781
2605784
2605785
2605788
2605789
2605790
2605796
2605797
35008_at
8059996
8864
A_23_P209320
A_23_P411162
GE53071
GO:0000122
GO:0000976
GO:0001222
GO:0002931
GO:0003013
GO:0003677
GO:0003713
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005975
GO:0005978
GO:0006091
GO:0006094
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006629
GO:0006631
GO:0007623
GO:0019229
GO:0019249
GO:0023052
GO:0030154
GO:0031397
GO:0032922
GO:0036211
GO:0042752
GO:0042754
GO:0043153
GO:0043226
GO:0045892
GO:0045893
GO:0048471
GO:0048511
GO:0048856
GO:0050767
GO:0050796
GO:0050872
GO:0051726
GO:0051946
GO:0055085
GO:0070345
GO:0097167
GO:0120162
GO:0140110
GO:2000678
HMNXSV003041161
ILMN_1738095
PH_hs_0024839
TC02002914.hg
g12707560_3p_a_at
g12707561_3p_at
Participates
as a member of
ub-p-PER1,ub-p-PER2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S-PER2 [cytosol]
p-S-PER2 [nucleoplasm]
PER2 [cytosol]
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_073728.1
,
XP_006712887.1
,
XP_005246168.1
OpenTargets
ENSG00000132326
HPA
ENSG00000132326-PER2
GeneCards
O15055
Ensembl
ENSP00000516757
,
ENSP00000254657
,
ENSP00000516758
,
ENST00000707130
,
ENST00000707129
,
ENST00000254657
,
ENSG00000132326
PRO
O15055
Pharos - Targets
O15055
Orphanet
17718
PDB
6OF7
,
8D7M
,
8D7O
,
8D7N
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.854
9
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.756
6
UniProt:P11441 UBL4A
1
UBL4A [cytosol]
(R-HSA-9609526)
0.556
3
UniProt:Q14241 ELOA
1
TCEB3 [nucleoplasm]
(R-HSA-112421)
0.556
3
UniProt:P61968 LMO4
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.556
3
UniProt:J3QSH9 J3QSH9
0.556
3
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.463
3
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