Reactome | WDR77 [nucleoplasm]

WDR77 [nucleoplasm]

Stable Identifier

R-HSA-5205610

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MEP50

Locations in the PathwayBrowser for interactor UniProt:Q9NY12 GAR1

Expand all

External Reference Information

External Reference

UniProt:Q9BQA1 WDR77

Gene Names

WDR77, MEP50, WD45, HKMT1069, Nbla10071

Chain

chain:1-342

Reference Genes

BioGPS Gene:79084 WDR77

COSMIC (genes):WDR77 WDR77

CTD Gene:79084 WDR77

dbSNP Gene:79084 WDR77

ENSEMBL:ENSG00000116455 WDR77

ENSEMBL_homo_sapiens_GENE:ENSG00000116455.14 WDR77

HGNC:29652 WDR77

KEGG Gene (Homo sapiens):79084 WDR77

Monarch:79084 WDR77

NCBI Gene:79084 WDR77

OMIM:611734 WDR77

UCSC:Q9BQA1 WDR77

Reference Transcript

Other Identifiers

11716081_a_at

11716082_s_at

11749299_a_at

11749300_x_at

11751686_a_at

16690843

201420_PM_s_at

201420_s_at

201421_PM_s_at

201421_s_at

2427932

2427933

2427934

2427935

2427936

2427937

2427938

2427939

2427940

2427941

2427942

2427943

2427944

2427945

2427946

2427951

2427955

2427956

2427957

2427958

2427960

2427962

2427965

2427967

2427968

2967689

38987_at

64494_at

79084

7918517

A_23_P115149

GE80209

GO:0000209

GO:0000387

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006511

GO:0007309

GO:0008284

GO:0008285

GO:0008327

GO:0016071

GO:0022414

GO:0030154

GO:0030163

GO:0030374

GO:0031465

GO:0034709

GO:0036211

GO:0043226

GO:0045893

GO:0048026

GO:0048856

GO:0060090

GO:0060528

GO:0060767

GO:0060770

GO:0065003

GO:0140110

GO:1990756

HMNXSV003028784

HMNXSV003050437

Hs.11039.0.S1_3p_s_at

ILMN_1742889

PH_hs_0026108

TC01002985.hg

g13129109_3p_s_at

p342

p343

Participates

as an input of

PRMT5 binds WDR77 (Homo sapiens)

as a component of

PRMT5:WDR77 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

pT5-WDR77 [nucleoplasm]

WDR77 [cytosol]

Inferred To

Wdr77 [nucleoplasm] (Mus musculus)

Wdr77 [nucleoplasm] (Rattus norvegicus)

WDR77 [nucleoplasm] (Bos taurus)

WDR77 [nucleoplasm] (Canis familiaris)

WDR77 [nucleoplasm] (Dictyostelium discoideum)

WDR77 [nucleoplasm] (Sus scrofa)

Ghost homologue of WDR77 [nucleoplasm] (Danio rerio)

Ghost homologue of WDR77 [nucleoplasm] (Schizosaccharomyces pombe)

vls [nucleoplasm] (Drosophila melanogaster)

wdr77 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_077007.1, NP_001303992.1, NP_001303991.1, NP_001303993.1

OpenTargets

ENSG00000116455

HPA

ENSG00000116455-WDR77

GeneCards

Q9BQA1

Ensembl

ENST00000235090, ENSP00000235090, ENSG00000116455

PRO

Q9BQA1

Pharos - Targets

Q9BQA1

PDB

6V0N, 7MX7, 6V0O, 7BO7, 8CSG, 8G1U, 4X60, 7SER, 7SES, 7S1Q, 7MXA, 6UXX, 7S1P, 6V0P, 4GQB, 7UYF, 7ZUP, 7S1S, 7M05, 7ZVU, 5EMM, 7KIB, 5EMK, 7S1R, 4X63, 8VEY, 5EML, 5C9Z, 7KID, 6UGH, 7UY1, 7S0U, 7KIC, 7ZUQ, 8VET, 8CYI, 6CKC, 6RLL, 6K1S, 7ZUY, 8VEO, 7ZVL, 7L1G, 8VEX, 5EMJ, 4X61, 7UOH, 7U30, 8VEW, 8VEU, 6RLQ, 8CTB, 7MXG, 6UXY, 7MXC, 5FA5, 7MXN, 7ZV2, 7ZUU

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.96	17
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.643	3
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.643	3
UniProt:P03418 N	4	p-N [viral capsid] (R-RSY-9835206) Nascent N [cytosol] (R-RSY-9831167) p-N [cytosol] (R-RSY-9823348) N [viral capsid] (R-RSY-9823364)	0.576	3
UniProt:P80318	1	Cct3 [cytosol] (R-MMU-390463)	0.564	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.527	3
UniProt:Q14011 CIRBP			0.527	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	3
UniProt:Q92526 CCT6B	1	CCT6B [cytosol] (R-HSA-5216201)	0.527	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	3
UniProt:P62312 LSM6	2	LSM6 [cytosol] (R-HSA-429936) LSM6 [nucleoplasm] (R-HSA-6806794)	0.527	2
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	3
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	3

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