LC3 binds the autophagosome membrane Atg5-Atg12 complex

Stable Identifier
R-HSA-5205663
Type
Reaction [binding]
Species
Homo sapiens
Compartment
phagocytic vesicle
ReviewStatus
5/5
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LC3 binds the autophagosome membrane Atg5-Atg12 complex
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The mitochondrion is engulfed after elongation of the isolation membrane. Once the autophagosome is formed, its outer membrane fuses with lysosomes to form the autolysosome. The lysosomal hydrolases (cathepsins and lipases) ultimately degrade the damaged mitochondrion and its associated proteins.
Literature References
PubMed ID Title Journal Year
20712405 Autophagosome formation and molecular mechanism of autophagy

Tanida, I

Antioxid. Redox Signal. 2011
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Orthologous Events
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Plasmodium falciparum)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Xenopus tropicalis)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)
Created
Gillespie, ME  (2013-12-05)
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