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PINK1 [mitochondrial intermembrane space]
Stable Identifier
R-HSA-5205671
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
Synonyms
Serine/threonine-protein kinase PINK1, mitochondrial ecNumber2.7.11.1/ecNumber, PINK1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O60260 PARK2
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Pink1 is cleaved on healthy mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
PINK1 [mitochondrial intermembrane space] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXM7 PINK1
Gene Names
PINK1
Chain
transit peptide:1-77, chain:78-581
Reference Genes
BioGPS Gene:65018 PINK1
COSMIC (genes):PINK1 PINK1
CTD Gene:65018 PINK1
dbSNP Gene:65018 PINK1
ENSEMBL:ENSG00000158828 PINK1
ENSEMBL_homo_sapiens_GENE:ENSG00000158828.8 PINK1
HGNC:14581 PINK1
KEGG Gene (Homo sapiens):65018 PINK1
Monarch:65018 PINK1
NCBI Gene:65018 PINK1
OMIM:608309 PINK1
UCSC:Q9BXM7 PINK1
Reference Transcript
RefSeq:NM_032409.2 PINK1
Other Identifiers
11726995_at
11726996_at
16660367
209018_PM_s_at
209018_s_at
209019_PM_s_at
209019_s_at
2324098
2324099
2324100
2324101
2324104
2324106
2324110
2324112
2324114
2324115
2324116
2324117
2324118
2324119
2324120
2324121
2324126
35361_at
65018
7898663
GE62219
GO:0000166
GO:0000287
GO:0000422
GO:0000423
GO:0000785
GO:0001934
GO:0002020
GO:0002082
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005743
GO:0005758
GO:0005783
GO:0005829
GO:0005856
GO:0006091
GO:0006468
GO:0006511
GO:0006886
GO:0006914
GO:0006950
GO:0006979
GO:0007005
GO:0010310
GO:0010629
GO:0010821
GO:0010857
GO:0010952
GO:0012501
GO:0014046
GO:0016020
GO:0016192
GO:0016239
GO:0016242
GO:0016301
GO:0016310
GO:0016504
GO:0016567
GO:0016740
GO:0018105
GO:0022904
GO:0023052
GO:0030097
GO:0030154
GO:0030163
GO:0030424
GO:0030426
GO:0031396
GO:0031398
GO:0031625
GO:0032148
GO:0032226
GO:0033138
GO:0033603
GO:0033605
GO:0034599
GO:0035307
GO:0035556
GO:0036211
GO:0036289
GO:0038203
GO:0042981
GO:0043066
GO:0043123
GO:0043226
GO:0043227
GO:0043229
GO:0043254
GO:0043422
GO:0043523
GO:0043524
GO:0044297
GO:0044877
GO:0045727
GO:0046329
GO:0046872
GO:0048471
GO:0048856
GO:0050432
GO:0050821
GO:0051246
GO:0051443
GO:0051649
GO:0051881
GO:0051897
GO:0055086
GO:0055131
GO:0061024
GO:0061136
GO:0065003
GO:0071456
GO:0072655
GO:0072656
GO:0090141
GO:0090200
GO:0090258
GO:0097237
GO:0097413
GO:0097449
GO:0098772
GO:0098779
GO:0099074
GO:0106310
GO:0140096
GO:1900407
GO:1901135
GO:1901525
GO:1902803
GO:1902902
GO:1902958
GO:1903146
GO:1903214
GO:1903298
GO:1903377
GO:1903384
GO:1903751
GO:1903852
GO:1903955
GO:1904544
GO:1904841
GO:1904881
GO:1904925
GO:2000377
GO:2000378
GO:2001171
GO:2001243
HMNXSV003041263
Hs.6163.0.A1_3p_a_at
ILMN_1666924
PH_hs_0025759
TC01000262.hg
g13492051_3p_a_at
Participates
as an input of
Pink1 is cleaved on healthy mitochondria (Homo sapiens)
Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)
as an output of
Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
Other forms of this molecule
p-S228,S402-PINK1 [mitochondrial outer membrane]
PINK1 [mitochondrial outer membrane]
PINK1 [cytosol]
PINK1(111-581) [mitochondrial intermembrane space]
Inferred To
PINK1 [mitochondrial intermembrane space]
(Bos taurus)
PINK1 [mitochondrial intermembrane space]
(Caenorhabditis elegans)
PINK1 [mitochondrial intermembrane space]
(Canis familiaris)
PINK1 [mitochondrial intermembrane space]
(Drosophila melanogaster)
PINK1 [mitochondrial intermembrane space]
(Mus musculus)
PINK1 [mitochondrial intermembrane space]
(Rattus norvegicus)
PINK1 [mitochondrial intermembrane space]
(Sus scrofa)
pink1 [mitochondrial intermembrane space]
(Danio rerio)
Cross References
RefSeq
NP_115785.1
Guide to Pharmacology - Targets
2161
OpenTargets
ENSG00000158828
HPA
ENSG00000158828-PINK1
GeneCards
Q9BXM7
Ensembl
ENSP00000364204
,
ENSG00000158828
,
ENST00000321556
PRO
Q9BXM7
Pharos - Targets
Q9BXM7
Orphanet
15094
HMDB Protein
HMDBP01217
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.748
7
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.576
8
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.57
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q9UHY8 FEZ2
0.556
3
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.556
3
IntAct:EBI-25842456 CCSB
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
UniProt:P00491 PNP
7
PNP R234P [cytosol]
(R-HSA-9735772)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [extracellular region]
(R-HSA-6806505)
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
PNP [cytosol]
(R-HSA-61933)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:Q8N895 ZN366
0.556
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.547
2
UniProt:O75153 CLU
0.527
3
UniProt:P48594 SPB4
0.527
2
UniProt:Q8IXI2 RHOT1
2
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
0.524
3
UniProt:Q96JZ2 HSH2D
0.488
2
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