Reactome | Parkin promotes the ubiquitination of mitochondrial substrates

Parkin promotes the ubiquitination of mitochondrial substrates

Stable Identifier

R-HSA-5205682

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Parkin promotes the ubiquitination of mitochondrial substrates

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Parkin promotes the ubiquitination of the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage-dependent anion-selective channel protein 1 (vDAC1), all of which are embedded in the OMM.

Literature References

PubMed ID	Title	Journal	Year
19432818	Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63 Kanthasamy, AG, Anantharam, V, Sun, F, Kanthasamy, A	J. Cell. Mol. Med.	2009