COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)

Stable Identifier
Reaction [transition]
Homo sapiens
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4
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PRMT5 can methylate histone H4 at arginine-4 (H4R3)and histone H2A at arginine-4 (H2AR3) (Pal et al. 2004). Symmetric dimethylation of histone H4 arginine-4 (H4R3me2s) by PRMT5 is required for subsequent DNA methylation. The histone-binding protein Cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008). H4R3me2s serves as a direct binding target for the DNA methyltransferase DNMT3A, which interacts through the ADD domain, which contains a PHD motif (Zhao et al. 2009).

Literature References
PubMed ID Title Journal Year
18404153 The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Rodier, G, Le Cam, A, Fabbrizio, E, Sardet, C, El Messaoudi, S, Lacroix, M

EMBO Rep. 2008
15485929 Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

Vishwanath, SN, Pal, S, Sif, S, Tempst, P, Erdjument-Bromage, H

Mol. Cell. Biol. 2004
Catalyst Activity

histone-arginine N-methyltransferase activity of CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm]

This event is regulated
Orthologous Events
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